
Vitamín D je esenciálny vitamín rozpustný v tukoch, ktorý syntetizuje naša pokožka, keď je vystavená slnku. Prospieva nám v mnohých smeroch, od zdravia kostí až po ovplyvnenie nálady.
AKA
Cholecalciferol (Vit. D3), Ergocalciferol (Vit. D2)
Zhrnutie
Vitamín D je živina rozpustná v tukoch. Je to jeden z 24 mikronutrientov kritických pre prežitie človeka. Slnko je jeho hlavným prírodným zdrojom, ale vitamín D sa prirodzene nachádza aj v rybách a vajciach. Pridáva sa aj do mliečnych výrobkov.
Užívanie doplnkov vitamínu D je spojené s množstvom pozitív, napr. zlepšenie kognitívnych funkcií, imunity, zdravia kostí a emočnej pohody. Suplementácia môže tiež znížiť riziko rakoviny, srdcových chorôb, cukrovky a roztrúsenej sklerózy. Ľudia s nedostatkom vitamínu D môžu po jeho doplnení zaznamenať aj zvýšenie hladiny testosterónu.
Telo si vytvára vitamín D z cholesterolu za predpokladu dostatočného množstva UV žiarenia zo slnečného žiarenia. Dostatočné množstvo UV svetla prichádza zo slnka len vtedy, keď je UV index 3 alebo vyšší, čo sa celoročne vyskytuje len v blízkosti rovníka, medzi 37. rovnobežkou.
Väčšina ľudí nemá nedostatok vitamínu D, no nemajú ani optimálnu hladinu vitamínu D. Kvôli mnohým zdravotným výhodám sa odporúča suplementácia vitamínu D, vždy ak v tele nie je optimálna hladina.
Ako užívať
Odporúčaná denná dávka vitamínu D je v súčasnosti stanovená na 400-800 IU/deň, čo je však pre dospelých príliš málo. Horná prípustná hladina príjmu v Spojených štátoch a Kanade je 4 000 IU/deň. Výskum naznačuje, že skutočná horná prípustná hladina príjmu je 10 000 IU/deň. Pre miernu suplementáciu je dostatočná dávka 1 000 – 2 000 IU vitamínu D3 na uspokojenie potrieb väčšiny populácie. Toto je najnižší rozsah účinných dávok. Vyššie dávky, na základe telesnej hmotnosti, sú v rozmedzí 20-80 IU/kg denne.
Viac sa odporúča suplementácia vitamínu D3 (cholekalciferol) ako suplementácia D2 (ergokalciferol), pretože D3 sa v tele využíva efektívnejšie.
Vitamín D by sa mal užívať denne spolu s jedlom obsahujúcim tuk. Je lepšie užívať ho ráno/doobeda. Dlhodobejšie večerné užívanie vitamínu D môže narušiť spánkový cyklus.
Upozornenie
Pri predávkovaní môže vitamín D pôsobiť. Toxicita je sprostredkovaná zmenou metabolizmu vápnika, čo môže byť potenciálne smrteľné. Bez lekárskeho dohľadu by denná dávka nemala prekročiť 10 000 IU.
Literatúra
- Sato Y, et al. Amelioration of osteopenia and hypovitaminosis D by 1alpha-hydroxyvitamin D3 in elderly patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry. (1999)
- Khajehei M, et al. Effect of treatment with dydrogesterone or calcium plus vitamin D on the severity of premenstrual syndrome. Int J Gynaecol Obstet. (2009)
- Wolpowitz D, Gilchrest BA. The vitamin D questions: how much do you need and how should you get it. J Am Acad Dermatol. (2006)
- Zhang R, Naughton DP. Vitamin D in health and disease: current perspectives. Nutr J. (2010)
- Calvo MS, Whiting SJ. Prevalence of vitamin D insufficiency in Canada and the United States: importance to health status and efficacy of current food fortification and dietary supplement use. Nutr Rev. (2003)
- Bowman SA. Beverage choices of young females: changes and impact on nutrient intakes. J Am Diet Assoc. (2002)
- Bartolucci G, et al. Vitamin D3 quantification in a cod liver oil-based supplement. J Pharm Biomed Anal. (2011)
- Monard AM, et al. Determination of the total vitamin D3 content of cod-liver oil by high-performance liquid chromatography. Pharm Acta Helv. (1986)
- Porojnicu AC, et al. Sun beds and cod liver oil as vitamin D sources. J Photochem Photobiol B. (2008)
- DRI DIETARY REFERENCE INTAKES FOR Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride.
- Holick MF. Resurrection of vitamin D deficiency and rickets. J Clin Invest. (2006)
- Whiting SJ, Green TJ, Calvo MS. Vitamin D intakes in North America and Asia-Pacific countries are not sufficient to prevent vitamin D insufficiency. J Steroid Biochem Mol Biol. (2007)
- Grant WB, Holick MF. Benefits and requirements of vitamin D for optimal health: a review. Altern Med Rev. (2005)
- Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr. (2005)
- Prosser DE, Jones G. Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem Sci. (2004)
- Frederick JE, Lubin D. The budget of biologically active ultraviolet radiation in the Earth-atmosphere system. J Geophys Res-Atmos. (1988)
- Ainsleigh HG. Beneficial effects of sun exposure on cancer mortality. Prev Med. (1993)
- Engelsen O, et al. Daily duration of vitamin D synthesis in human skin with relation to latitude, total ozone, altitude, ground cover, aerosols and cloud thickness. Photochem Photobiol. (2005)
- O’Connor PA. Clouds, skin color, and rickets. Pediatrics. (1980)
- Webb AR, Kline L, Holick MF. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab. (1988)
- Lubin D, Jensen EH, Gies HP. Global surface ultraviolet radiation climatology from TOMS and ERBE data. J Geophys Res-Atmos. (1998)
- Coney P, et al. Determination of vitamin D in relation to body mass index and race in a defined population of black and white women. Int J Gynaecol Obstet. (2012)
- Fiscella K, Franks P. Vitamin D, race, and cardiovascular mortality: findings from a national US sample. Ann Fam Med. (2010)
- Manson JE, et al. The case for a comprehensive national campaign to prevent melanoma and associated mortality. Epidemiology. (2000)
- Garland CF, Garland FC, Gorham ED. Could sunscreens increase melanoma risk. Am J Public Health. (1992)
- Diffey BL. Sunscreens as a preventative measure in melanoma: an evidence-based approach or the precautionary principle. Br J Dermatol. (2009)
- Matsuoka LY, Wortsman J, Hollis BW. Use of topical sunscreen for the evaluation of regional synthesis of vitamin D3. J Am Acad Dermatol. (1990)
- Matsuoka LY, et al. Sunscreens suppress cutaneous vitamin D3 synthesis. J Clin Endocrinol Metab. (1987)
- Matsuoka LY, et al. Chronic sunscreen use decreases circulating concentrations of 25-hydroxyvitamin D. A preliminary study. Arch Dermatol. (1988)
- Vitamin D Metabolism, Mechanism of Action, and Clinical Applications.
- Holick MF, et al. Photosynthesis of previtamin D3 in human skin and the physiologic consequences. Science. (1980)
- Vieth R. Why „Vitamin D“ is not a hormone, and not a synonym for 1,25-dihydroxy-vitamin D, its analogs or deltanoids. J Steroid Biochem Mol Biol. (2004)
- Holick MF. The use and interpretation of assays for vitamin D and its metabolites. J Nutr. (1990)
- Binkley N, et al. Evaluation of ergocalciferol or cholecalciferol dosing, 1,600 IU daily or 50,000 IU monthly in older adults. J Clin Endocrinol Metab. (2011)
- Houghton LA, Vieth R. The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am J Clin Nutr. (2006)
- Holick MF, et al. Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab. (2008)
- Biancuzzo RM, et al. Fortification of orange juice with vitamin D(2) or vitamin D(3) is as effective as an oral supplement in maintaining vitamin D status in adults. Am J Clin Nutr. (2010)
- Glendenning P, et al. Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after supplementation with ergocalciferol and cholecalciferol. Bone. (2009)
- Tjellesen L, et al. Serum concentration of vitamin D metabolites during treatment with vitamin D2 and D3 in normal premenopausal women. Bone Miner. (1986)
- Trang HM, et al. Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2. Am J Clin Nutr. (1998)
- Armas LA, Hollis BW, Heaney RP. Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. (2004)
- Romagnoli E, et al. Short and long-term variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) in the elderly. J Clin Endocrinol Metab. (2008)
- Tripkovic L, et al. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr. (2012)
- DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. (2004)
- Huber W, Barlow OW. CHEMICAL AND BIOLOGICAL STABILITY OF CRYSTALLINE VITAMINS D2 AND D3 AND THEIR DERIVATIVES. J Biol Chem. (1943)
- Grady LT, Thakker KD. Stability of solid drugs: degradation of ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3) at high humidities and elevated temperatures. J Pharm Sci. (1980)
- Dietary Reference Intakes for Calcium and Vitamin D..
- Vitamin D Fact Sheet for Health Professionals.
- Visser M, et al. Low serum concentrations of 25-hydroxyvitamin D in older persons and the risk of nursing home admission. Am J Clin Nutr. (2006)
- Bischoff-Ferrari HA, et al. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. (2006)
- Ginde AA, Liu MC, Camargo CA Jr. Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004. Arch Intern Med. (2009)
- Brock K, et al. Low vitamin D status is associated with physical inactivity, obesity and low vitamin D intake in a large US sample of healthy middle-aged men and women. J Steroid Biochem Mol Biol. (2010)
- Tangpricha V, et al. Vitamin D insufficiency among free-living healthy young adults. Am J Med. (2002)
- Hyppönen E, Power C. Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors. Am J Clin Nutr. (2007)
- Kull M Jr, et al. Seasonal variance of 25-(OH) vitamin D in the general population of Estonia, a Northern European country. BMC Public Health. (2009)
- Hovsepian S, et al. Prevalence of vitamin D deficiency among adult population of Isfahan City, Iran. J Health Popul Nutr. (2011)
- Levis S, et al. Vitamin d deficiency and seasonal variation in an adult South Florida population. J Clin Endocrinol Metab. (2005)
- van der Mei IA, et al. The high prevalence of vitamin D insufficiency across Australian populations is only partly explained by season and latitude. Environ Health Perspect. (2007)
- Thomas MK, et al. Hypovitaminosis D in medical inpatients. N Engl J Med. (1998)
- Melamed ML, et al. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med. (2008)
- Vieth R, et al. The urgent need to recommend an intake of vitamin D that is effective. Am J Clin Nutr. (2007)
- Heaney RP, et al. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. (2003)
- Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. (1999)
- Autier P, Gandini S, Mullie P. A systematic review: influence of vitamin D supplementation on serum 25-hydroxyvitamin D concentration. J Clin Endocrinol Metab. (2012)
- Mastaglia SR, et al. Vitamin D2 dose required to rapidly increase 25OHD levels in osteoporotic women. Eur J Clin Nutr. (2006)
- Corless D, et al. Do vitamin D supplements improve the physical capabilities of elderly hospital patients. Age Ageing. (1985)
- Cranney A, et al. Summary of evidence-based review on vitamin D efficacy and safety in relation to bone health. Am J Clin Nutr. (2008)
- Grant WB, Schuitemaker GE. Health benefits of higher serum 25-hydroxyvitamin D levels in The Netherlands. J Steroid Biochem Mol Biol. (2010)
- Barger-Lux MJ, et al. Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men. Osteoporos Int. (1998)
- Gertner JM, Domenech M. 25-Hydroxyvitamin D levels in patients treated with high-dosage ergo- and cholecalciferol. J Clin Pathol. (1977)
- Harris SS, Dawson-Hughes B. Plasma vitamin D and 25OHD responses of young and old men to supplementation with vitamin D3. J Am Coll Nutr. (2002)
- Pepper KJ, et al. Evaluation of vitamin D repletion regimens to correct vitamin D status in adults. Endocr Pract. (2009)
- Dawson-Hughes B, et al. Meal conditions affect the absorption of supplemental vitamin D3 but not the plasma 25-hydroxyvitamin D response to supplementation. J Bone Miner Res. (2013)
- Dawson-Hughes B, et al. Dietary fat increases vitamin D-3 absorption. J Acad Nutr Diet. (2015)
- Glade MJ. A 21st century evaluation of the safety of oral vitamin D. Nutrition. (2012)
- Papaioannou A, et al. A randomized controlled trial of vitamin D dosing strategies after acute hip fracture: no advantage of loading doses over daily supplementation. BMC Musculoskelet Disord. (2011)
- Ford ES, et al. Vitamin D and all-cause mortality among adults in USA: findings from the National Health and Nutrition Examination Survey Linked Mortality Study. Int J Epidemiol. (2011)
- Kritchevsky SB1, et al. 25-Hydroxyvitamin D, parathyroid hormone, and mortality in black and white older adults: the health ABC study. J Clin Endocrinol Metab. (2012)
- Smit E, et al. The effect of vitamin D and frailty on mortality among non-institutionalized US older adults. Eur J Clin Nutr. (2012)
- Bjelakovic G1, et al. Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev. (2014)
- Grant WB, Garland CF, Gorham ED. An estimate of cancer mortality rate reductions in Europe and the US with 1,000 IU of oral vitamin D per day. Recent Results Cancer Res. (2007)
- Noordam R, et al. Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study. CMAJ. (2012)
- Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. (2014)
- Capiati D, Benassati S, Boland RL. 1,25(OH)2-vitamin D3 induces translocation of the vitamin D receptor (VDR) to the plasma membrane in skeletal muscle cells. J Cell Biochem. (2002)
- Blomberg Jensen M, Dissing S. Non-genomic effects of vitamin D in human spermatozoa. Steroids. (2012)
- Nemere I1, et al. Ribozyme knockdown functionally links a 1,25(OH)2D3 membrane binding protein (1,25D3-MARRS) and phosphate uptake in intestinal cells. Proc Natl Acad Sci U S A. (2004)
- Sequeira VB1, et al. The role of the vitamin D receptor and ERp57 in photoprotection by 1α,25-dihydroxyvitamin D3. Mol Endocrinol. (2012)
- Simpson ER1, et al. Aromatase–rief overview. Annu Rev Physiol. (2002)
- Yanase T1, et al. Aromatase in bone: roles of Vitamin D3 and androgens. J Steroid Biochem Mol Biol. (2003)
- c Krishnan AV, et al. Tissue-selective regulation of aromatase expression by calcitriol: implications for breast cancer therapy. Endocrinology. (2010)
- Lou YR1, Murtola T, Tuohimaa P. Regulation of aromatase and 5alpha-reductase by 25-hydroxyvitamin D(3), 1alpha,25-dihydroxyvitamin D(3), dexamethasone and progesterone in prostate cancer cells. J Steroid Biochem Mol Biol. (2005)
- Barrera D, et al. Estradiol and progesterone synthesis in human placenta is stimulated by calcitriol. J Steroid Biochem Mol Biol. (2007)
- Kinuta K, et al. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology. (2000)
- Lundqvist J, Hansen SK, Lykkesfeldt AE. Vitamin D analog EB1089 inhibits aromatase expression by dissociation of comodulator WSTF from the CYP19A1 promoter-a new regulatory pathway for aromatase. Biochim Biophys Acta. (2012)
- Christensen GL, et al. Sequential versus combined treatment of human breast cancer cells with antiestrogens and the vitamin D analogue EB1089 and evaluation of predictive markers for vitamin D treatment. Breast Cancer Res Treat. (2004)
- Larsen SS, Heiberg I, Lykkesfeldt AE. Anti-oestrogen resistant human breast cancer cell lines are more sensitive towards treatment with the vitamin D analogue EB1089 than parent MCF-7 cells. Br J Cancer. (2001)
- Waltman NL, et al. Vitamin D insufficiency and musculoskeletal symptoms in breast cancer survivors on aromatase inhibitor therapy. Cancer Nurs. (2009)
- Cella D, Fallowfield LJ. Recognition and management of treatment-related side effects for breast cancer patients receiving adjuvant endocrine therapy. Breast Cancer Res Treat. (2008)
- Singh S, et al. Effect of baseline serum vitamin D levels on aromatase inhibitors induced musculoskeletal symptoms: results from the IBIS-II, chemoprevention study using anastrozole. Breast Cancer Res Treat. (2012)
- Prieto-Alhambra D, et al. Vitamin D threshold to prevent aromatase inhibitor-induced arthralgia: a prospective cohort study. Breast Cancer Res Treat. (2011)
- Rastelli AL, et al. Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial. Breast Cancer Res Treat. (2011)
- Zehnder D, et al. Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab. (2001)
- Eyles DW, et al. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat. (2005)
- Rothman SM, Olney JW. Excitotoxity and the NMDA receptor. Trends Neurosci. (1987)
- Choi DW. Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci. (1988)
- Choi DW. Excitotoxic cell death. J Neurobiol. (1992)
- Nicotera P, Orrenius S. The role of calcium in apoptosis. Cell Calcium. (1998)
- Brewer LD, et al. Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons. J Neurosci. (2001)
- Meszaros JG1, et al. Down-regulation of L-type Ca2+ channel transcript levels by 1,25-dihyroxyvitamin D3. Osteoblastic cells express L-type alpha1C Ca2+ channel isoforms. J Biol Chem. (1996)
- Caffrey JM1, Farach-Carson MC. Vitamin D3 metabolites modulate dihydropyridine-sensitive calcium currents in clonal rat osteosarcoma cells. J Biol Chem. (1989)
- Weiss JH1, et al. The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicity. Science. (1990)
- Uematsu D1, et al. Combined therapy with MK-801 and nimodipine for protection of ischemic brain damage. Neurology. (1991)
- Landfield PW, Cadwallader-Neal L. Long-term treatment with calcitriol (1,25(OH)2 vit D3) retards iomarker of hippocampal aging in rats. Neurobiol Aging. (1998)
- Dean AJ, et al. Effects of vitamin D supplementation on cognitive and emotional functioning in young adults–a randomised controlled trial. PLoS One. (2011)
- Pettersen JA. Does high dose vitamin D supplementation enhance cognition?: A randomized trial in healthy adults. Exp Gerontol. (2017)
- Bech P, Hey H. Depression or asthenia related to metabolic disturbances in obese patients after intestinal bypass surgery. Acta Psychiatr Scand. (1979)
- May HT, et al. Association of vitamin D levels with incident depression among a general cardiovascular population. Am Heart J. (2010)
- Armstrong DJ, et al. Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol. (2007)
- Shipowick CD, et al. Vitamin D and depressive symptoms in women during the winter: a pilot study. Appl Nurs Res. (2009)
- Högberg G, et al. Depressed adolescents in a case-series were low in vitamin D and depression was ameliorated by vitamin D supplementation. Acta Paediatr. (2012)
- Sepehrmanesh Z, et al. Vitamin D Supplementation Affects the Beck Depression Inventory, Insulin Resistance, and Biomarkers of Oxidative Stress in Patients with Major Depressive Disorder: A Randomized, Controlled Clinical Trial. J Nutr. (2016)
- van Loo HM, et al. Data-driven subtypes of major depressive disorder: a systematic review. BMC Med. (2012)
- Yalamanchili V, Gallagher JC. Treatment with hormone therapy and calcitriol did not affect depression in older postmenopausal women: no interaction with estrogen and vitamin D receptor genotype polymorphisms. Menopause. (2012)
- Ascherio A, Munger KL, Simon KC. Vitamin D and multiple sclerosis. Lancet Neurol. (2010)
- Compston A, Coles A. Multiple sclerosis. Lancet. (2008)
- Kurtzke JF, Beebe GW, Norman JE Jr. Epidemiology of multiple sclerosis in U.S. veterans: 1. Race, sex, and geographic distribution. Neurology. (1979)
- Simpson S Jr, et al. Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis. J Neurol Neurosurg Psychiatry. (2011)
- Islam T, et al. Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins. Neurology. (2007)
- Dalmay F, et al. Multiple sclerosis and solar exposure before the age of 15 years: case-control study in Cuba, Martinique and Sicily. Mult Scler. (2010)
- Salzer J1, et al. Vitamin D as a protective factor in multiple sclerosis. Neurology. (2012)
- Lemire JM, Archer DC. 1,25-dihydroxyvitamin D3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis. J Clin Invest. (1991)
- Cantorna MT, Hayes CE, DeLuca HF. 1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc Natl Acad Sci U S A. (1996)
- van Etten E, et al. Novel insights in the immune function of the vitamin D system: synergism with interferon-beta. J Steroid Biochem Mol Biol. (2007)
- Wergeland S, et al. Dietary vitamin D3 supplements reduce demyelination in the cuprizone model. PLoS One. (2011)
- Lu’o’ng KV, Nguyên LT. The beneficial role of vitamin D in Alzheimer’s disease. Am J Alzheimers Dis Other Demen. (2011)
- Annweiler C, Llewellyn DJ, Beauchet O. Low Serum Vitamin D Concentrations in Alzheimer’s Disease: A Systematic Review and Meta-Analysis. J Alzheimers Dis. (2012)
- Evatt ML, et al. Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease. Arch Neurol. (2008)
- Sato Y, Kikuyama M, Oizumi K. High prevalence of vitamin D deficiency and reduced bone mass in Parkinson’s disease. Neurology. (1997)
- Gezen-Ak D, et al. Vitamin d receptor gene haplotype is associated with late-onset Alzheimer’s disease. Tohoku J Exp Med. (2012)
- Annweiler C, et al. Serum vitamin D deficiency as a predictor of incident non-Alzheimer dementias: a 7-year longitudinal study. Dement Geriatr Cogn Disord. (2011)
- Mizwicki MT, et al. 1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer’s disease patients. J Alzheimers Dis. (2013)
- Wirdefeldt K, et al. Epidemiology and etiology of Parkinson’s disease: a review of the evidence. Eur J Epidemiol. (2011)
- Knekt P, et al. Serum vitamin D and the risk of Parkinson disease. Arch Neurol. (2010)
- Butler MW, et al. Vitamin D receptor gene as a candidate gene for Parkinson disease. Ann Hum Genet. (2011)
- Kim JS, et al. Association of vitamin D receptor gene polymorphism and Parkinson’s disease in Koreans. J Korean Med Sci. (2005)
- Evatt ML, et al. High prevalence of hypovitaminosis D status in patients with early Parkinson disease. Arch Neurol. (2011)
- Sato Y, et al. Abnormal bone and calcium metabolism in immobilized Parkinson’s disease patients. Mov Disord. (2005)
- Evatt ML. Beyond vitamin status: is there a role for vitamin d in Parkinson disease. Arch Neurol. (2010)
- Newmark HL, Newmark J. Vitamin D and Parkinson’s disease–a hypothesis. Mov Disord. (2007)
- Dean ED, et al. 25-Hydroxyvitamin D depletion does not exacerbate MPTP-induced dopamine neuron damage in mice. PLoS One. (2012)
- Shinpo K, et al. Effect of 1,25-dihydroxyvitamin D(3) on cultured mesencephalic dopaminergic neurons to the combined toxicity caused by L-buthionine sulfoximine and 1-methyl-4-phenylpyridine. J Neurosci Res. (2000)
- Wang JY, et al. Vitamin D(3) attenuates 6-hydroxydopamine-induced neurotoxicity in rats. Brain Res. (2001)
- Gominak SC, Stumpf WE. The world epidemic of sleep disorders is linked to vitamin D deficiency. Med Hypotheses. (2012)
- Bonnet MH, Arand DL. We are chronically sleep deprived. Sleep. (1995)
- Van Cauter E, et al. Metabolic consequences of sleep and sleep loss. Sleep Med. (2008)
- Huang W, et al. Improvement of Pain, Sleep, and Quality of Life in Chronic Pain Patients With Vitamin D Supplementation. Clin J Pain. (2012)
- Mucci M, et al. Soy isoflavones, lactobacilli, Magnoliark extract, vitamin D3 and calcium. Controlled clinical study in menopause. Minerva Ginecol. (2006)
- Wang TJ, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation. (2008)
- Wang L, et al. Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular events. Ann Intern Med. (2010)
- Wood AD1, et al. Vitamin D3 supplementation has no effect on conventional cardiovascular risk factors: a parallel-group, double-blind, placebo-controlled RCT. J Clin Endocrinol Metab. (2012)
- Seibert E, et al. Vitamin D3 supplementation does not modify cardiovascular risk profile of adults with inadequate vitamin D status. Eur J Nutr. (2015)
- Rostand SG. Ultraviolet light may contribute to geographic and racial blood pressure differences. Hypertension. (1997)
- Krause R, et al. Ultraviolet B and blood pressure. Lancet. (1998)
- Weng S, et al. Vitamin d deficiency induces high blood pressure and accelerates atherosclerosis in mice. PLoS One. (2013)
- Li YC, et al. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest. (2002)
- Ritthaler T, et al. Effects of endothelins on renin secretion from isolated mouse renal juxtaglomerular cells. Am J Physiol. (1995)
- Witham MD, Nadir MA, Struthers AD. Effect of vitamin D on blood pressure: a systematic review and meta-analysis. J Hypertens. (2009)
- Lind L, et al. Reduction of blood pressure during long-term treatment with active vitamin D (alphacalcidol) is dependent on plasma renin activity and calcium status. A double-blind, placebo-controlled study. Am J Hypertens. (1989)
- Pfeifer M, et al. Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. J Clin Endocrinol Metab. (2001)
- Xiang W, et al. Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems. Am J Physiol Endocrinol Metab. (2005)
- Kong J1, Li YC. Effect of ANG II type I receptor antagonist and ACE inhibitor on vitamin D receptor-null mice. Am J Physiol Regul Integr Comp Physiol. (2003)
- Dostal DE, Baker KM. Angiotensin II stimulation of left ventricular hypertrophy in adult rat heart. Mediation by the AT1 receptor. Am J Hypertens. (1992)
- Baker KM, Booz GW, Dostal DE. Cardiac actions of angiotensin II: Role of an intracardiac renin-angiotensin system. Annu Rev Physiol. (1992)
- Al Mheid I, et al. Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans. J Am Coll Cardiol. (2011)
- Yiu YF, et al. Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. J Clin Endocrinol Metab. (2011)
- Reis JP, et al. Differences in vitamin D status as a possible contributor to the racial disparity in peripheral arterial disease. Am J Clin Nutr. (2008)
- Zittermann A, et al. Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Am J Clin Nutr. (2009)
- Tabas I. The role of endoplasmic reticulum stress in the progression of atherosclerosis. Circ Res. (2010)
- Feng B, et al. The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat Cell Biol. (2003)
- Devries-Seimon T, et al. Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J Cell Biol. (2005)
- Szeto FL, et al. Vitamin D receptor signaling inhibits atherosclerosis in mice. Mol Endocrinol. (2012)
- Oh J, et al. Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation. J Biol Chem. (2012)
- Martinez FO, et al. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J Immunol. (2006)
- Bouhlel MA, et al. PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties. Cell Metab. (2007)
- Feig JE, et al. LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression. J Clin Invest. (2010)
- Mills CD, et al. M-1/M-2 macrophages and the Th1/Th2 paradigm. J Immunol. (2000)
- Liu E, et al. Plasma 25-hydroxyvitamin d is associated with markers of the insulin resistant phenotype in nondiabetic adults. J Nutr. (2009)
- Ford ES, et al. Associations between concentrations of vitamin D and concentrations of insulin, glucose, and HbA1c among adolescents in the United States. Diabetes Care. (2011)
- Kelly A, et al. A cross-sectional study of vitamin D and insulin resistance in children. Arch Dis Child. (2011)
- Chiu KC, et al. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. (2004)
- Nazarian S, et al. Vitamin D3 supplementation improves insulin sensitivity in subjects with impaired fasting glucose. Transl Res. (2011)
- Choi HS, et al. Low serum vitamin D is associated with high risk of diabetes in Korean adults. J Nutr. (2011)
- Knekt P, et al. Serum vitamin D and subsequent occurrence of type 2 diabetes. Epidemiology. (2008)
- Devaraj S, et al. Low vitamin D levels correlate with the proinflammatory state in type 1 diabetic subjects with and without microvascular complications. Am J Clin Pathol. (2011)
- Mitri J, et al. Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial. Am J Clin Nutr. (2011)
- Foss YJ. Vitamin D deficiency is the cause of common obesity. Med Hypotheses. (2009)
- Ruff CB. Climatic adaptation and hominid evolution: The thermoregulatory imperative. Evol Anthropol. (1993)
- Hunt G1, Roy K. Climate change, body size evolution, and Cope’s Rule in deep-sea ostracodes. Proc Natl Acad Sci U S A. (2006)
- Zhang Z, Zhang Z. Comment on „Vitamin D deficiency is the cause of common obesity“. Med Hypotheses. (2009)
- Zamboni G, et al. Mineral metabolism in obese children. Acta Paediatr Scand. (1988)
- Yanoff LB, et al. The prevalence of hypovitaminosis D and secondary hyperparathyroidism in obese Black Americans. Clin Endocrinol (Oxf). (2006)
- Sutherland ER, et al. Vitamin D levels, lung function, and steroid response in adult asthma. Am J Respir Crit Care Med. (2010)
- Josefson JL, et al. Maternal obesity and vitamin D sufficiency are associated with cord blood vitamin D insufficiency. J Clin Endocrinol Metab. (2013)
- Bell NH, et al. Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest. (1985)
- Vimaleswaran KS1, et al. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med. (2013)
- Choi H, Myung K. Vitamin D3 regulation of body fat, cytokines, and calpain gene expression. J Sci Food Agr. (2012)
- Carrillo AE, et al. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Clin Nutr. (2012)
- Salehpour A1, et al. A 12-week double-blind randomized clinical trial of vitamin D₃ supplementation on body fat mass in healthy overweight and obese women. Nutr J. (2012)
- Norman AW. Receptors for 1alpha,25(OH)2D3: past, present, and future. J Bone Miner Res. (1998)
- Nemere I, et al. Identification of a membrane receptor for 1,25-dihydroxyvitamin D3 which mediates rapid activation of protein kinase C. J Bone Miner Res. (1998)
- Morelli S, Boland R, de Boland AR. 1,25(OH)2-vitamin D3 stimulation of phospholipases C and D in muscle cells involves extracellular calcium and a pertussis-sensitive G protein. Mol Cell Endocrinol. (1996)
- de Boland AR, Morelli S, Boland R. 1,25(OH)2-vitamin D3 signal transduction in chick myoblasts involves phosphatidylcholine hydrolysis. J Biol Chem. (1994)
- de Boland AR, Boland RL. 1,25-Dihydroxyvitamin D-3 induces arachidonate mobilization in embryonic chick myoblasts. Biochim Biophys Acta. (1993)
- Li YC, et al. Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci U S A. (1997)
- Wang Y, Becklund BR, DeLuca HF. Identification of a highly specific and versatile vitamin D receptor antibody. Arch Biochem Biophys. (2010)
- Is the Vitamin D Receptor Found in Muscle?.
- Stumpf WE, et al. Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid. Science. (1979)
- Pike JW, Goozé LL, Haussler MR. Biochemical evidence for 1,25-dihydroxyvitamin D receptor macromolecules in parathyroid, pancreatic, pituitary, and placental tissues. Life Sci. (1980)
- Narbaitz R, et al. Autoradiographic demonstration of target cells for 1,25-dihydroxycholecalciferol in the chick embryo chorioallantoic membrane, duodenum, and parathyroid glands. Gen Comp Endocrinol. (1980)
- Minasyan A, et al. Vestibular dysfunction in vitamin D receptor mutant mice. J Steroid Biochem Mol Biol. (2009)
- Kalueff AV, et al. Impaired motor performance in mice lacking neurosteroid vitamin D receptors. Brain Res Bull. (2004)
- Endo I, et al. Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology. (2003)
- Owens DJ, et al. A systems-based investigation into vitamin D and skeletal muscle repair, regeneration, and hypertrophy. Am J Physiol Endocrinol Metab. (2015)
- Gilsanz V, et al. Vitamin D status and its relation to muscle mass and muscle fat in young women. J Clin Endocrinol Metab. (2010)
- Goswami R, et al. Skeletal muscle strength in young Asian Indian females after vitamin D and calcium supplementation: a double-blind randomized controlled clinical trial. J Clin Endocrinol Metab. (2012)
- Cannell JJ, et al. Athletic performance and vitamin D. Med Sci Sports Exerc. (2009)
- Galan F, et al. Serum 25-hydroxyvitamin D in early autumn to ensure vitamin D sufficiency in mid-winter in professional football players. Clin Nutr. (2012)
- Shindle MK, et al. Vitamin D Status in a Professional American Football Team: 2008: Board #203 June 2 9:00 AM – 10:30 AM. Med Sci Sports Exerc. (2011)
- Halliday TM, et al. Vitamin D status relative to diet, lifestyle, injury, and illness in college athletes. Med Sci Sports Exerc. (2011)
- Burgi AA, et al. High serum 25-hydroxyvitamin D is associated with a low incidence of stress fractures. J Bone Miner Res. (2011)
- Atkins GJ, et al. Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3. Bone. (2007)
- van Leeuwen JP, et al. Vitamin D control of osteoblast function and bone extracellular matrix mineralization. Crit Rev Eukaryot Gene Expr. (2001)
- van Driel M, Pols HA, van Leeuwen JP. Osteoblast differentiation and control by vitamin D and vitamin D metabolites. Curr Pharm Des. (2004)
- Atkins GJ, et al. RANKL expression is related to the differentiation state of human osteoblasts. J Bone Miner Res. (2003)
- Matsumoto T, et al. Stimulation by 1,25-dihydroxyvitamin D3 of in vitro mineralization induced by osteoblast-like MC3T3-E1 cells. Bone. (1991)
- Ruohola JP, et al. Association between serum 25(OH)D concentrations and bone stress fractures in Finnish young men. J Bone Miner Res. (2006)
- Tenforde AS, et al. Evaluating the relationship of calcium and vitamin D in the prevention of stress fracture injuries in the young athlete: a review of the literature. PM R. (2010)
- Lappe J, et al. Calcium and vitamin d supplementation decreases incidence of stress fractures in female navy recruits. J Bone Miner Res. (2008)
- Bischoff-Ferrari HA, et al. Effect of Vitamin D on falls: a meta-analysis. JAMA. (2004)
- Monaghan H. Review: prophylactic use of vitamin D reduces falls in older people. Evid Based Nurs. (2004)
- Gillespie LD, et al. Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev. (2012)
- Glover TL1, et al. Vitamin D, race, and experimental pain sensitivity in older adults with knee osteoarthritis. Arthritis Rheum. (2012)
- McAlindon T, et al. Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA. (2013)
- Riek AE1, et al. Vitamin D suppression of endoplasmic reticulum stress promotes an antiatherogenic monocyte/macrophage phenotype in type 2 diabetic patients. J Biol Chem. (2012)
- c Kim G, Bae JH. Vitamin D and atopic dermatitis: A systematic review and meta-analysis. Nutrition. (2016)
- Barton M, Sidbury R. Advances in understanding and managing atopic dermatitis. F1000Res. (2015)
- Boguniewicz M, Leung DY. Recent insights into atopic dermatitis and implications for management of infectious complications. J Allergy Clin Immunol. (2010)
- Williams H, et al. Worldwide variations in the prevalence of symptoms of atopic eczema in the International Study of Asthma and Allergies in Childhood. J Allergy Clin Immunol. (1999)
- Amestejani M, et al. Vitamin D supplementation in the treatment of atopic dermatitis: a clinical trial study. J Drugs Dermatol. (2012)
- Holick MF. Vitamin D deficiency. N Engl J Med. (2007)
- Wehr E, et al. Association of vitamin D status with serum androgen levels in men. Clin Endocrinol (Oxf). (2010)
- Bischoff-Ferrari HA, Orav EJ, Dawson-Hughes B. Additive benefit of higher testosterone levels and vitamin D plus calcium supplementation in regard to fall risk reduction among older men and women. Osteoporos Int. (2008)
- Pilz S, et al. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res. (2011)
- Garland CF, et al. Vitamin D and prevention of breast cancer: pooled analysis. J Steroid Biochem Mol Biol. (2007)
- Garland CF, et al. The role of vitamin D in cancer prevention. Am J Public Health. (2006)
- Garland FC, et al. Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation. Prev Med. (1990)
- Gorham ED, Garland CF, Garland FC. Acid haze air pollution and breast and colon cancer mortality in 20 Canadian cities. Can J Public Health. (1989)
- Peppone LJ, et al. The effect of various vitamin D supplementation regimens in breast cancer patients. Breast Cancer Res Treat. (2011)
- Nesby-O’Dell S, et al. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr. (2002)
- Chlebowski RT, et al. Calcium plus vitamin D supplementation and the risk of breast cancer. J Natl Cancer Inst. (2008)
- Crew KD, et al. High prevalence of vitamin D deficiency despite supplementation in premenopausal women with breast cancer undergoing adjuvant chemotherapy. J Clin Oncol. (2009)
- Gorham ED, et al. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Am J Prev Med. (2007)
- Skinner HG, et al. Vitamin D intake and the risk for pancreatic cancer in two cohort studies. Cancer Epidemiol Biomarkers Prev. (2006)
- Garland CF, et al. Role of ultraviolet B irradiance and vitamin D in prevention of ovarian cancer. Am J Prev Med. (2006)
- Vashi PG, et al. Serum 25-hydroxyvitamin D is inversely associated with body mass index in cancer. Nutr J. (2011)
- Choi CJ, et al. Relationship Between Serum 25-Hydroxyvitamin D and Lung Function Among Korean Adults in Korea National Health and Nutrition Examination Survey (KNHANES), 2008-2010. J Clin Endocrinol Metab. (2013)
- Searing DA, et al. Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy Clin Immunol. (2010)
- Urashima M, et al. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. (2010)
- Lange NE1, et al. Vitamin D deficiency, smoking, and lung function in the Normative Aging Study. Am J Respir Crit Care Med. (2012)
- Camargo CA Jr1, et al. Randomized trial of vitamin D supplementation and risk of acute respiratory infection in Mongolia. Pediatrics. (2012)
- Aloia JF, Li-Ng M. Re: epidemic influenza and vitamin D. Epidemiol Infect. (2007)
- Murdoch DR1, et al. Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: the VIDARIS randomized controlled trial. JAMA. (2012)
- Nnoaham KE, Clarke A. Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis. Int J Epidemiol. (2008)
- Bozkurt NC, et al. The relation of serum 25-hydroxyvitamin-D levels with severity of obstructive sleep apnea and glucose metabolism abnormalities. Endocrine. (2012)
- Stumpf WE. Vitamin D sites and mechanisms of action: a histochemical perspective. Reflections on the utility of autoradiography and cytopharmacology for drug targeting. Histochem Cell Biol. (1995)
- Blomberg Jensen M, et al. Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract. Hum Reprod. (2010)
- Yoshida M, Kawano N, Yoshida K. Control of sperm motility and fertility: diverse factors and common mechanisms. Cell Mol Life Sci. (2008)
- Nangia AK, et al. Testicular maturation arrest to testis cancer: spectrum of expression of the vitamin D receptor and vitamin D treatment in vitro. J Urol. (2007)
- Bouillon R, et al. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev. (2008)
- Kwiecinski GG, Petrie GI, DeLuca HF. Vitamin D is necessary for reproductive functions of the male rat. J Nutr. (1989)
- Blomberg Jensen M, et al. Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Hum Reprod. (2011)
- Hammoud AO, et al. Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters. Asian J Androl. (2012)
- Yang B, et al. Associations between testosterone, bone mineral density, vitamin D and semen quality in fertile and infertile Chinese men. Int J Androl. (2012)
- Blomberg Jensen M. Vitamin D metabolism, sex hormones, and male reproductive function. Reproduction. (2012)
- van der Meer IM, et al. High prevalence of vitamin D deficiency in pregnant non-Western women in The Hague, Netherlands. Am J Clin Nutr. (2006)
- Haliloglu B, et al. Bone turnover and maternal 25(OH) vitamin D3 levels during pregnancy and the postpartum period: should routine vitamin D supplementation be increased in pregnant women. Eur J Obstet Gynecol Reprod Biol. (2011)
- Johnson DD, et al. Vitamin D deficiency and insufficiency is common during pregnancy. Am J Perinatol. (2011)
- Hamilton SA, et al. Profound Vitamin D Deficiency in a Diverse Group of Women during Pregnancy Living in a Sun-Rich Environment at Latitude 32°N. Int J Endocrinol. (2010)
- Gernand AD, et al. Maternal serum 25-hydroxyvitamin D and measures of newborn and placental weight in a U.S. multicenter cohort study. J Clin Endocrinol Metab. (2013)
- Sørensen IM, et al. Maternal serum levels of 25-hydroxy-vitamin D during pregnancy and risk of type 1 diabetes in the offspring. Diabetes. (2012)
- Erkkola M, et al. Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. Clin Exp Allergy. (2009)
- Merewood A, et al. Association between vitamin D deficiency and primary cesarean section. J Clin Endocrinol Metab. (2009)
- Bodnar LM, Krohn MA, Simhan HN. Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J Nutr. (2009)
- Yu CK, et al. Vitamin D deficiency and supplementation during pregnancy. Clin Endocrinol (Oxf). (2009)
- Hollis BW, Wagner CL. Assessment of dietary vitamin D requirements during pregnancy and lactation. Am J Clin Nutr. (2004)
- Terrier B, et al. Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation. Arthritis Res Ther. (2012)
- Warner AE, Arnspiger SA. Diffuse musculoskeletal pain is not associated with low vitamin D levels or improved by treatment with vitamin D. J Clin Rheumatol. (2008)
- Schreuder F, Bernsen RM, van der Wouden JC. Vitamin d supplementation for nonspecific musculoskeletal pain in non-Western immigrants: a randomized controlled trial. Ann Fam Med. (2012)
- Arvold DS, et al. Correlation of symptoms with vitamin D deficiency and symptom response to cholecalciferol treatment: a randomized controlled trial. Endocr Pract. (2009)
- Bischoff-Ferrari HA, et al. Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res. (2004)
- Bischoff HA, et al. Muscle strength in the elderly: its relation to vitamin D metabolites. Arch Phys Med Rehabil. (1999)
- Visser M, Deeg DJ, Lips P; Longitudinal Aging Study Amsterdam. Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam. J Clin Endocrinol Metab. (2003)
- Sato Y, et al. Low-dose vitamin D prevents muscular atrophy and reduces falls and hip fractures in women after stroke: a randomized controlled trial. Cerebrovasc Dis. (2005)
- Verhaar HJ, et al. Muscle strength, functional mobility and vitamin D in older women. Aging (Milano). (2000)
- Kidd PM. Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy. Altern Med Rev. (2010)
- Heaney RP, et al. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr. (2003)
- Bjelakovic G, et al. Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev. (2011)
- Abnet CC, et al. Serum 25(OH)-vitamin D concentration and risk of esophageal squamous dysplasia. Cancer Epidemiol Biomarkers Prev. (2007)
- Dobnig H, et al. Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch Intern Med. (2008)
- Pfeifer M, et al. Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int. (2009)
- Barker T, et al. Different doses of supplemental vitamin D maintain interleukin-5 without altering skeletal muscle strength: a randomized, double-blind, placebo-controlled study in vitamin D sufficient adults. Nutr Metab (Lond). (2012)
- Ganmaa D, et al. Vitamin D, tuberculin skin test conversion, and latent tuberculosis in Mongolian school-age children: a randomized, double-blind, placebo-controlled feasibility trial. Am J Clin Nutr. (2012)
- Khan QJ, et al. Effect of vitamin D supplementation on serum 25-hydroxy vitamin D levels, joint pain, and fatigue in women starting adjuvant letrozole treatment for breast cancer. Breast Cancer Res Treat. (2010)
- Borissova AM, et al. The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J Clin Pract. (2003)
- Jørgensen SP, et al. Clinical trial: vitamin D3 treatment in Crohn’s disease – a randomized double-blind placebo-controlled study. Aliment Pharmacol Ther. (2010)
- Broe KE, et al. A higher dose of vitamin d reduces the risk of falls in nursing home residents: a randomized, multiple-dose study. J Am Geriatr Soc. (2007)
- Parker J, et al. Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis. Maturitas. (2010)
- Bischoff-Ferrari HA, et al. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med. (2009)
- Abrams SA, Hawthorne KM, Chen Z. Supplementation with 1000 IU vitamin D/d leads to parathyroid hormone suppression, but not increased fractional calcium absorption, in 4-8-y-old children: a double-blind randomized controlled trial. Am J Clin Nutr. (2013)
- Gepner AD, et al. A prospective randomized controlled trial of the effects of vitamin D supplementation on cardiovascular disease risk. PLoS One. (2012)
- Sato Y, Honda Y, Iwamoto J. Risedronate and ergocalciferol prevent hip fracture in elderly men with Parkinson disease. Neurology. (2007)
- Bogh MK, et al. Narrowband ultraviolet B three times per week is more effective in treating vitamin D deficiency than 1600 IU oral vitamin D₃ per day: a randomized clinical trial. Br J Dermatol. (2012)
- Harris SS, Pittas AG, Palermo NJ. A randomized, placebo-controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African Americans. Diabetes Obes Metab. (2012)
- McAlindon TE, et al. Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham Study. Ann Intern Med. (1996)
- Pierrot-Deseilligny C, et al. Relationship between 25-OH-D serum level and relapse rate in multiple sclerosis patients before and after vitamin D supplementation. Ther Adv Neurol Disord. (2012)
- Mohr SB, et al. The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. Diabetologia. (2008)
- Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey. Am J Hypertens. (2007)
- Kositsawat J, et al. Association of A1C levels with vitamin D status in U.S. adults: data from the National Health and Nutrition Examination Survey. Diabetes Care. (2010)
- Lappe JM, et al. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr. (2007)
- Bischoff-Ferrari HA, et al. Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ. (2009)
- Fariba Almassinokiani, et al. Effects of Vitamin D on Endometriosis-Related Pain: A Double-Blind Clinical Trial. Med Sci Monit. (2016)
- Pfeifer M, et al. Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res. (2000)
- Jorde R, et al. Vitamin D supplementation did not prevent influenza-like illness as diagnosed retrospectively by questionnaires in subjects participating in randomized clinical trials. Scand J Infect Dis. (2012)
- Crew KD, et al. Association between plasma 25-hydroxyvitamin D and breast cancer risk. Cancer Prev Res (Phila). (2009)
- Heidari H, et al. Vitamin D Supplementation for Premenstrual Syndrome-Related inflammation and antioxidant markers in students with vitamin D deficient: a randomized clinical trial. Sci Rep. (2019)
- Abdollahi R, et al. The Effect of Vitamin D Supplement Consumption on Premenstrual Syndrome in Vitamin D-Deficient Young Girls: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Complement Med Res. (2019)
- Bahrami A, et al. High dose vitamin D supplementation can improve menstrual problems, dysmenorrhea, and premenstrual syndrome in adolescents. Gynecol Endocrinol. (2018)
- Dadkhah H, Ebrahimi E, Fathizadeh N. Evaluating the effects of vitamin D and vitamin E supplement on premenstrual syndrome: A randomized, double-blind, controlled trial. Iran J Nurs Midwifery Res. (2016)
- Tartagni M, et al. Vitamin D Supplementation for Premenstrual Syndrome-Related Mood Disorders in Adolescents with Severe Hypovitaminosis D. J Pediatr Adolesc Gynecol. (2016)
- Majid MS, et al. The effect of vitamin D supplement on the score and quality of sleep in 20-50 year-old people with sleep disorders compared with control group. Nutr Neurosci. (2018)
- Rees JR, et al. Vitamin D3 supplementation and upper respiratory tract infections in a randomized, controlled trial. Clin Infect Dis. (2013)
- Martineau AR, et al. Double-blind randomised controlled trial of vitamin D3 supplementation for the prevention of acute respiratory infection in older adults and their carers (ViDiFlu). Thorax. (2015)
- Li-Ng M, et al. A randomized controlled trial of vitamin D3 supplementation for the prevention of symptomatic upper respiratory tract infections. Epidemiol Infect. (2009)
- Laaksi I, et al. Vitamin D supplementation for the prevention of acute respiratory tract infection: a randomized, double-blinded trial among young Finnish men. J Infect Dis. (2010)
- Bergman P, et al. Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study. BMJ Open. (2012)
- Goodall EC, et al. Vitamin D3 and gargling for the prevention of upper respiratory tract infections: a randomized controlled trial. BMC Infect Dis. (2014)
- Dubnov-Raz G, et al. Vitamin D supplementation and upper respiratory tract infections in adolescent swimmers: a randomized controlled trial. Pediatr Exerc Sci. (2015)
- Denlinger LC, et al. Vitamin D Supplementation and the Risk of Colds in Patients with Asthma. Am J Respir Crit Care Med. (2016)
- Ginde AA, et al. High-Dose Monthly Vitamin D for Prevention of Acute Respiratory Infection in Older Long-Term Care Residents: A Randomized Clinical Trial. J Am Geriatr Soc. (2017)
- Avenell A, et al. Vitamin D supplementation to prevent infections: a sub-study of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438). Age Ageing. (2007)
- Choudhary N, Gupta P. Vitamin D supplementation for severe pneumonia–a randomized controlled trial. Indian Pediatr. (2012)
- Camargo CA, et al. Effect of monthly high-dose vitamin D supplementation on acute respiratory infections in older adults: A randomized controlled trial. Clin Infect Dis. (2019)
- Loeb M, et al. Effect of Vitamin D supplementation to reduce respiratory infections in children and adolescents in Vietnam: A randomized controlled trial. Influenza Other Respir Viruses. (2019)
- Jung HC, et al. Vitamin D₃ Supplementation Reduces the Symptoms of Upper Respiratory Tract Infection during Winter Training in Vitamin D-Insufficient Taekwondo Athletes: A Randomized Controlled Trial. Int J Environ Res Public Health. (2018)
- Urashima M, et al. Effects of vitamin D supplements on influenza A illness during the 2009 H1N1 pandemic: a randomized controlled trial. Food Funct. (2014)
- Shimizu Y, et al. Intake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study. J Nutr Health Aging. (2018)
- Zhou J, et al. Preventive Effects of Vitamin D on Seasonal Influenza A in Infants: A Multicenter, Randomized, Open, Controlled Clinical Trial. Pediatr Infect Dis J. (2018)
- Hauger H, et al. Winter cholecalciferol supplementation at 55°N has little effect on markers of innate immune defense in healthy children aged 4-8 years: a secondary analysis from a randomized controlled trial. Eur J Nutr. (2019)
- Aglipay M, et al. Effect of High-Dose vs Standard-Dose Wintertime Vitamin D Supplementation on Viral Upper Respiratory Tract Infections in Young Healthy Children. JAMA. (2017)
- Somnath SH, et al. Therapeutic effect of vitamin D in acute lower respiratory infection: A randomized controlled trial. Clin Nutr ESPEN. (2017)
- David D Chandy, et al. Effect of vitamin D supplementation, directly or vireast milk for term infants, on serum 25 hydroxyvitamin D and related biochemistry, and propensity to infection: a randomised placebo-controlled trial. Br J Nutr. (2016)
- Martineau AR, et al. Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis. Health Technol Assess. (2019)
- Martineau AR, et al. Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3 supplementation in adults with asthma (ViDiAs). Thorax. (2015)
- Manaseki-Holland S, et al. Effects of vitamin D supplementation to children diagnosed with pneumonia in Kabul: a randomised controlled trial. Trop Med Int Health. (2010)
- Marchisio P, et al. Vitamin D supplementation reduces the risk of acute otitis media in otitis-prone children. Pediatr Infect Dis J. (2013)
- Grant CC, et al. Reduced primary care respiratory infection visits following pregnancy and infancy vitamin D supplementation: a randomised controlled trial. Acta Paediatr. (2015)
- Marta Entrenas Castillo, et al. „Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study“. J Steroid Biochem Mol Biol. (2020)
- William Camu, et al. Cholecalciferol in relapsing-remitting MS: A randomized clinical trial (CHOLINE). Neurol Neuroimmunol Neuroinflamm. (2019)
- Raymond Hupperts, et al. Randomized trial of daily high-dose vitamin D 3 in patients with RRMS receiving subcutaneous interferon β-1a. Neurology. (2019)
- Margitta T Kampman, et al. Effect of vitamin D3 supplementation on relapses, disease progression, and measures of function in persons with multiple sclerosis: exploratory outcomes from a double-blind randomised controlled trial. Mult Scler. (2012)
- Vahid Shaygannejad, et al. Effects of adjunct low-dose vitamin d on relapsing-remitting multiple sclerosis progression: preliminary findings of a randomized placebo-controlled trial. Mult Scler Int. (2012)
- Ghasem Mosayebi, et al. Therapeutic effect of vitamin D3 in multiple sclerosis patients. Immunol Invest. (2011)
- P Fox, et al. The effect of cannabis on tremor in patients with multiple sclerosis. Neurology. (2004)
- J Killestein, et al. Safety, tolerability, and efficacy of orally administered cannabinoids in MS. Neurology. (2002)
- Jody Corey-Bloom, et al. Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial. CMAJ. (2012)
- Shaun Sabico, et al. Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial. Nutrients. (2021)
- Maheshwar Lakkireddy, et al. Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease. Sci Rep. (2021)
- Igor H Murai, et al. Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial. JAMA. (2021)
- James L Nodler, et al. Supplementation with vitamin D or ω-3 fatty acids in adolescent girls and young women with endometriosis (SAGE): a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. (2020)
- Abolfazl Mehdizadehkashi, et al. The effect of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis. Gynecol Endocrinol. (2021)
- Nair R, Maseeh A. Vitamin D: The „sunshine“ vitamin. J Pharmacol Pharmacother. (2012)
- Parker GB, Brotchie H, Graham RK. Vitamin D and depression. J Affect Disord. (2017)
- Allan GM, et al. Vitamin D: A Narrative Review Examining the Evidence for Ten Beliefs. J Gen Intern Med. (2016)
- Gowda U, et al. Vitamin D supplementation to reduce depression in adults: meta-analysis of randomized controlled trials. Nutrition. (2015)
- Spedding S. Vitamin D and depression: a systematic review and meta-analysis comparing studies with and without biological flaws. Nutrients. (2014)
- Vellekkatt F, Menon V. Efficacy of vitamin D supplementation in major depression: A meta-analysis of randomized controlled trials. J Postgrad Med. (2018)
- Vaziri F, et al. A randomized controlled trial of vitamin D supplementation on perinatal depression: in Iranian pregnant mothers. BMC Pregnancy Childbirth. (2016)
- Laurent MR, et al. Hypervitaminosis D Associated With Tanning Bed Use: A Case Report. Ann Intern Med. (2017)
- Rodgers S, et al. Serum testosterone levels and symptom-based depression subtypes in men. Front Psychiatry. (2015)
- Johnson JM, Nachtigall LB, Stern TA. The effect of testosterone levels on mood in men: a review. Psychosomatics. (2013)
- Bassil N, Alkaade S, Morley JE. The benefits and risks of testosterone replacement therapy: a review. Ther Clin Risk Manag. (2009)
- Zarrouf FA, et al. Testosterone and depression: systematic review and meta-analysis. J Psychiatr Pract. (2009)
- Davis SR, Wahlin-Jacobsen S. Testosterone in women–the clinical significance. Lancet Diabetes Endocrinol. (2015)
- Sharma A, Madaan V, Petty FD. Exercise for mental health. Prim Care Companion J Clin Psychiatry. (2006)
- Melrose S. Seasonal Affective Disorder: An Overview of Assessment and Treatment Approaches. Depress Res Treat. (2015)
- O’Hare C, et al. Seasonal and meteorological associations with depressive symptoms in older adults: A geo-epidemiological study. J Affect Disord. (2016)
- Golden RN, et al. The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence. Am J Psychiatry. (2005)
- Lam RW, et al. The Can-SAD study: a randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder. Am J Psychiatry. (2006)
- Kerr DC, et al. Associations between vitamin D levels and depressive symptoms in healthy young adult women. Psychiatry Res. (2015)
- Frandsen TB, et al. Vitamin D supplementation for treatment of seasonal affective symptoms in healthcare professionals: a double-blind randomised placebo-controlled trial. BMC Res Notes. (2014)
- Forrest KY, Stuhldreher WL. Prevalence and correlates of vitamin D deficiency in US adults. Nutr Res. (2011)
- Haq A, et al. Vitamin D deficiency: A single centre analysis of patients from 136 countries. J Steroid Biochem Mol Biol. (2016)
- Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium, et al. Dietary Reference Intakes for Calcium and Vitamin D.
- Heaney R, et al. Letter to Veugelers, P.J. and Ekwaru, J.P., A statistical error in the estimation of the recommended dietary allowance for vitamin D. Nutrients 2014, 6, 4472-4475; doi:10.3390/nu6104472. Nutrients. (2015)
- Veugelers PJ, Ekwaru JP. A statistical error in the estimation of the recommended dietary allowance for vitamin D. Nutrients. (2014)
- Fulgoni VL 3rd, et al. Foods, fortificants, and supplements: Where do Americans get their nutrients?. J Nutr. (2011)
- Blumberg JB, et al. Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups. Nutrients. (2017)
- Moore CE, Radcliffe JD, Liu Y. Vitamin D intakes of adults differ by income, gender and race/ethnicity in the U.S.A., 2007 to 2010. Public Health Nutr. (2014)
- Zittermann A, et al. Vitamin D supplementation, body weight and human serum 25-hydroxyvitamin D response: a systematic review. Eur J Nutr. (2014)
- Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc. (2010)
- Bordelon P, Ghetu MV, Langan RC. Recognition and management of vitamin D deficiency. Am Fam Physician. (2009)
- Maggio M, et al. The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men. Int J Endocrinol. (2014)
- Maggio M, et al. Magnesium and anabolic hormones in older men. Int J Androl. (2011)
- Martínez-Cengotitabengoa M, González-Pinto A. Nutritional supplements in depressive disorders. Actas Esp Psiquiatr. (2017)
- Cortese BM, Phan KL. The role of glutamate in anxiety and related disorders. CNS Spectr. (2005)
- Bergink V, van Megen HJ, Westenberg HG. Glutamate and anxiety. Eur Neuropsychopharmacol. (2004)
- Tarleton EK, Littenberg B. Magnesium intake and depression in adults. J Am Board Fam Med. (2015)
- Derom ML, et al. Magnesium and depression: a systematic review. Nutr Neurosci. (2013)
- Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. (2017)
- Fard FE, et al. Effects of zinc and magnesium supplements on postpartum depression and anxiety: A randomized controlled clinical trial. Women Health. (2017)
- Phelan D, et al. Magnesium and mood disorders: systematic review and meta-analysis. BJPsych Open. (2018)
- Nielsen FH, Lukaski HC. Update on the relationship between magnesium and exercise. Magnes Res. (2006)
- Costello RB, Moser-Veillon PB. A review of magnesium intake in the elderly. A cause for concern?. Magnes Res. (1992)
- Tang YM, et al. Relationships between micronutrient losses in sweat and blood pressure among heat-exposed steelworkers. Ind Health. (2016)
- Institute of Medicine (US) Committee on Military Nutrition Research; Marriott BM, editor. Washington (DC). Nutritional Needs in Hot Environments, “Influence of Exercise and Heat on Magnesium Metabolism”. National Academies Press (US). (1993)
- Consolazio CF, et al. Excretion of sodium, potassium, magnesium and iron in human sweat and the relation of each to balance and requirements. J Nutr. (1963)
- Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride, page 242.
- Yoshimura Y, et al. Pharmacokinetic Studies of Orally Administered Magnesium Oxide in Rats. Yakugaku Zasshi. (2017)
- Firoz M, Graber M. Bioavailability of US commercial magnesium preparations. Magnes Res. (2001)
- Li Z, et al. Association of total zinc, iron, copper and selenium intakes with depression in the US adults. J Affect Disord. (2018)
- Roy A, et al. Higher zinc intake buffers the impact of stress on depressive symptoms in pregnancy. Nutr Res. (2010)
- Ranjbar E, et al. Effects of zinc supplementation in patients with major depression: a randomized clinical trial. Iran J Psychiatry. (2013)
- Swardfager W, et al. Potential roles of zinc in the pathophysiology and treatment of major depressive disorder. Neurosci Biobehav Rev. (2013)
- Nowak G, et al. Effect of zinc supplementation on antidepressant therapy in unipolar depression: a preliminary placebo-controlled study. Pol J Pharmacol. (2003)
- Netter A, Hartoma R, Nahoul K. Effect of zinc administration on plasma testosterone, dihydrotestosterone, and sperm count. Arch Androl. (1981)
- Chang CS, et al. Correlation between serum testosterone level and concentrations of copper and zinc in hair tissue. Biol Trace Elem Res. (2011)
- Institute of Medicine (US) Panel on Micronutrients. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc.
- Singh M, Das RR. Zinc for the common cold. Cochrane Database Syst Rev. (2011)
- Valentiner-Branth P, et al. A randomized controlled trial of the effect of zinc as adjuvant therapy in children 2-35 mo of age with severe or nonsevere pneumonia in Bhaktapur, Nepal. Am J Clin Nutr. (2010)
- Willis MS, et al. Zinc-induced copper deficiency: a report of three cases initially recognized on bone marrow examination. Am J Clin Pathol. (2005)
- Afrin LB. Fatal copper deficiency from excessive use of zinc-based denture adhesive. Am J Med Sci. (2010)
- Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc, page 446.
- Meunier N, et al. Importance of zinc in the elderly: the ZENITH study. Eur J Clin Nutr. (2005)
- Blumberg J. Nutritional needs of seniors. J Am Coll Nutr. (1997)
- Tipton K, et al. Zinc loss in sweat of athletes exercising in hot and neutral temperatures. Int J Sport Nutr. (1993)
- Cashman KD, et al. Improved Dietary Guidelines for Vitamin D: Application of Individual Participant Data (IPD)-Level Meta-Regression Analyses. Nutrients. (2017)
- Grosso G, et al. Dietary n-3 PUFA, fish consumption and depression: A systematic review and meta-analysis of observational studies. J Affect Disord. (2016)
- Mocking RJ, et al. Meta-analysis and meta-regression of omega-3 polyunsaturated fatty acid supplementation for major depressive disorder. Transl Psychiatry. (2016)
- Burhani MD, Rasenick MM. Fish oil and depression: The skinny on fats. J Integr Neurosci. (2017)
- Bastiaansen JA, et al. The efficacy of fish oil supplements in the treatment of depression: food for thought. Transl Psychiatry. (2016)
- Lane K, et al. Bioavailability and potential uses of vegetarian sources of omega-3 fatty acids: a review of the literature. Crit Rev Food Sci Nutr. (2014)
- Hussein N, et al. Long-chain conversion of 13Clinoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men. J Lipid Res. (2005)
- Pawlosky RJ, et al. Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. J Lipid Res. (2001)
- Fokkema MR, et al. Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. Prostaglandins Leukot Essent Fatty Acids. (2000)
- Emken EA, Adlof RO, Gulley RM. Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. Biochim Biophys Acta. (1994)
- Protein and Amino Acid Requirements in Human Nutrition, page 245, table 49.
- Jenkins TA, et al. Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis. Nutrients. (2016)
- Cowen PJ, Browning M. What has serotonin to do with depression?. World Psychiatry. (2015)
- Feder A, et al. Tryptophan depletion and emotional processing in healthy volunteers at high risk for depression. Biol Psychiatry. (2011)
- Richard DM, et al. L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications. Int J Tryptophan Res. (2009)
- Young SN, Leyton M. The role of serotonin in human mood and social interaction. Insight from altered tryptophan levels. Pharmacol Biochem Behav. (2002)
- Lindseth G, Helland B, Caspers J. The effects of dietary tryptophan on affective disorders. Arch Psychiatr Nurs. (2015)
- Kroes MC, et al. Food can lift mood by affecting mood-regulating neurocircuits via a serotonergic mechanism. Neuroimage. (2014)
- Møller SE, Kirk L, Honoré P. Relationship between plasma ratio of tryptophan to competing amino acids and the response to L-tryptophan treatment in endogenously depressed patients. J Affect Disord. (1980)
- Bikle DD. Vitamin D metabolism and function in the skin. Mol Cell Endocrinol. (2011)
- Antony R Young, Joël Claveau, Aneatris Rossi. Ultraviolet radiation and the skin: Photobiology and sunscreen photoprotection. J Am Acad Dermatol. (2017)
- A Faurschou, et al. The relation between sunscreen layer thickness and vitamin D production after ultraviolet B exposure: a randomized clinical trial. Br J Dermatol. (2012)
- Mantas Grigalavicius, Vladimir Iani, Asta Juzeniene. Layer Thickness of SPF 30 Sunscreen and Formation of Pre-vitamin D. Anticancer Res. (2016)
- Libon F, et al. Sunscreens block cutaneous vitamin D production with only a minimal effect on circulating 25-hydroxyvitamin D. Arch Osteoporos. (2017)
- Bibi Petersen, Hans Christian Wulf. Application of sunscreen–theory and reality. Photodermatol Photoimmunol Photomed. (Apr-Jun)
- R E Neale, et al. The effect of sunscreen on vitamin D: a review. Br J Dermatol. (2019)
- T Passeron, et al. Sunscreen photoprotection and vitamin D status. Br J Dermatol. (2019)
- Barbar Shih, et al. Fractional Sunburn Threshold UVR Doses Generate Equivalent Vitamin D and DNA Damage in Skin Types I-VI but with Epidermal DNA Damage Gradient Correlated to Skin Darkness. J Invest Dermatol. (2018)
- Ann R Webb, et al. Colour Counts: Sunlight and Skin Type as Drivers of Vitamin D Deficiency at UK Latitudes. Nutrients. (2018)
- Ann R Webb, et al. Meeting Vitamin D Requirements in White Caucasians at UK Latitudes: Providing a Choice. Nutrients. (2018)
- A R Webb, B R DeCosta, M F Holick. Sunlight regulates the cutaneous production of vitamin D3 by causing its photodegradation. J Clin Endocrinol Metab. (1989)
- Engelsen O, Kylling A. Fast simulation tool for ultraviolet radiation at the earth’s surface. Opt Eng. (2005)
- John C Dowdy, Robert M Sayre, Michael F Holick. Holick’s rule and vitamin D from sunlight. J Steroid Biochem Mol Biol. (2010)
- Vitaly Terushkin, et al. Estimated equivalency of vitamin D production from natural sun exposure versus oral vitamin D supplementation across seasons at two US latitudes. J Am Acad Dermatol. (2010)
- Ann R Webb, Ola Engelsen. Calculated ultraviolet exposure levels for a healthy vitamin D status. Photochem Photobiol. (Nov-Dec)
- Travison TG, et al. The relationship between libido and testosterone levels in aging men. J Clin Endocrinol Metab. (2006)
- Chrysohoou C, et al. Low total testosterone levels are associated with the metabolic syndrome in elderly men: the role of body weight, lipids, insulin resistance, and inflammation; the Ikaria study. Rev Diabet Stud. (2013)
- Westley CJ, Amdur RL, Irwig MS. High Rates of Depression and Depressive Symptoms among Men Referred for Borderline Testosterone Levels. J Sex Med. (2015)
- Giltay EJ, et al. Salivary testosterone: associations with depression, anxiety disorders, and antidepressant use in a large cohort study. J Psychosom Res. (2012)
- Feldman HA, et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. J Clin Endocrinol Metab. (2002)
- Wu FC, et al. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. J Clin Endocrinol Metab. (2008)
- Handelsman DJ, et al. Age-specific population centiles for androgen status in men. Eur J Endocrinol. (2015)
- Cote KA, et al. Sleep deprivation lowers reactive aggression and testosterone in men. Biol Psychol. (2013)
- Leproult R, Van Cauter E. Effect of 1 week of sleep restriction on testosterone levels in young healthy men. JAMA. (2011)
- Penev PD. Association between sleep and morning testosterone levels in older men. Sleep. (2007)
- González-Santos MR, et al. Sleep deprivation and adaptive hormonal responses of healthy men. Arch Androl. (1989)
- Cortés-Gallegos V, et al. Sleep deprivation reduces circulating androgens in healthy men. Arch Androl. (1983)
- Nedeltcheva AV, et al. Insufficient sleep undermines dietary efforts to reduce adiposity. Ann Intern Med. (2010)
- O’Leary CB, Hackney AC. Acute and chronic effects of resistance exercise on the testosterone and cortisol responses in obese males: a systematic review. Physiol Res. (2014)
- Kraemer WJ, Ratamess NA. Hormonal responses and adaptations to resistance exercise and training. Sports Med. (2005)
- Daly W, et al. Relationship between stress hormones and testosterone with prolonged endurance exercise. Eur J Appl Physiol. (2005)
- Hackney AC, Aggon E. Chronic Low Testosterone Levels in Endurance Trained Men: The Exercise- Hypogonadal Male Condition. J Biochem Physiol. (2018)
- Grossmann M. Low testosterone in men with type 2 diabetes: significance and treatment. J Clin Endocrinol Metab. (2011)
- Tajar A, et al. Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European Male Ageing Study. J Clin Endocrinol Metab. (2010)
- Hall SA, et al. Correlates of low testosterone and symptomatic androgen deficiency in a population-based sample. J Clin Endocrinol Metab. (2008)
- Grossmann M, Matsumoto AM. A Perspective on Middle-Aged and Older Men With Functional Hypogonadism: Focus on Holistic Management. J Clin Endocrinol Metab. (2017)
- Corona G, et al. Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis. Eur J Endocrinol. (2013)
- Camacho EM, et al. Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study. Eur J Endocrinol. (2013)
- Uwitonze AM, Razzaque MS. Role of Magnesium in Vitamin D Activation and Function. J Am Osteopath Assoc. (2018)
- Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride.
- Gonzales-Arimborgo C, et al. Acceptability, Safety, and Efficacy of Oral Administration of Extracts of Black or Red Maca (Lepidium meyenii) in Adult Human Subjects: A Randomized, Double-Blind, Placebo-Controlled Study. Pharmaceuticals (Basel). (2016)
- Zenico T, et al. Subjective effects of Lepidium meyenii (Maca) extract on well-being and sexual performances in patients with mild erectile dysfunction: a randomised, double-blind clinical trial. Andrologia. (2009)
- Gonzales GF, et al. Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrologia. (2002)
- Dording CM, et al. A double-blind placebo-controlled trial of maca root as treatment for antidepressant-induced sexual dysfunction in women. Evid Based Complement Alternat Med. (2015)
- G. D’Aniello, et al. D-asparate, a key element for the improvement of sperm quality. Advances in Sexual Medicine. (2012)
- Topo E, et al. The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. Reprod Biol Endocrinol. (2009)
- Melville GW, Siegler JC, Marshall PW. Three and six grams supplementation of d-aspartic acid in resistance trained men. J Int Soc Sports Nutr. (2015)
- Willoughby DS, Leutholtz B. D-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men. Nutr Res. (2013)
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