Psyllium

494605425

Pôsobí na: funkciu čriev, zlepšenie citlivosti buniek na inzulín, správne fungovanie obehovej sústavy

Psyllium (zvyčajne v podobe šupiek alebo prášku) je vlákno pochádzajúce z rastliny
skorocel indický (Plantago psyllium), ktoré je schopné viazať mastné kyseliny a cholesterol zo stravy. Môže zvýšiť vlhkosť a hmotnosť stolice.

AKA
Metamucil (názov predajnej značky), ispaghula, plantago psyllium, plantago ovata, plantago, skorocel indický

Zhrnutie

Názov “Psyllium” sa bežne používa na označenie vlákien získaných z rastliny známej ako Plantago ovata (Skorocel vajcovitý, s. indický); jeho vláknina sa vyznačuje tým, že je vo vode rozpustná (hydrofilná) a vytvára gél, pričom má nízku fermentovateľnosť. Je všeobecne známy pod značkou Metamucil.

Psyllium sa klinicky používa ako objemové laxatívum; činidlo, ktoré má v dôsledku zvyšovania objemu výkalov laxatívne účinky. V porovnaní s chemickými látkami, ako je kofeín alebo senna alexandrina je psyllium  jemnejšie preháňadlo. K zväčšeniu objemu stolice dochádza v dôsledku absorpcie vody a plynu v tenkom a hrubom čreve, čím trávenina (vzniknutá zo spracovávanej potravy) nadobúda väčší objem a mäkkosť. Tento objem sa zdržiava v hrubom čreve aj napriek mikroflóre, pretože psyllium je slabo fermentovateľné (vysoko fermentovateľná vláknina môže byť metabolizovaná baktériami v hrubom čreve a stráca schopnosť zadržiavať vodu a udržať svoj objem). Je dokázané, že psyllium zvyšuje veľkosť a vlhkosť výkalov a vytvára mäkkú, hladkú a ľahko priechodnú stolicu. V porovnaní s inými zdrojmi vlákniny sa psyllium javí ako účinnejšie pri tvorbe výkalov a zdá sa, že je jedným z mála zdrojov vlákniny, ktoré nesúvisia s nadmernou plynatosťou.
Okrem fekálnych vlastností sa ukazuje, že psyllium je schopné znížiť celkový cholesterol a LDL cholesterol u osôb s vysokým cholesterolom a tiež dochádza k miernemu zníženiu  HDL. Toto je spoločné pre všetky typy vlákniny a nie je to jedinečné pre psyllium.

S užívaním psyllia sú spojené niektoré vlastnosti súvisiace so znížením glukózy, čo môže byť prospešné pre diabetikov. Zníženie glukózy nie je príliš účinné, ale je spoľahlivé, pokiaľ sa psyllium užíva; zastavenie užívania psyllia je spojené so zvýšením hladiny glukózy, čo je spoločné pre všetky rozpustné potravinové vlákniny.

Keď sa psyllium užíva vo vysokých dávkach, môže mierne znížiť chuť do jedla, ale nezdá sa, že by táto jeho schopnosť bola veľmi účinná alebo spoľahlivá. Dlhodobé výskumy používajúce psyllium v ​​dávkach na reguláciu výkalov nepreukázali, že by psyllium pôsobilo na zníženie hmotnosti, čo naznačuje, že to nie je dobrý spôsob regulácie hmotnosti.

Ako užívať

Dolná hranica dávkovania je 5 g denne spolu s jedlom a nejakou tekutinou (aspoň 200 ml vody). Ak je to potrebné môže sa užívať pri každom jedle. Užívanie spolu s jedlom nie je povinné ale psyllium je vždy potrebné užívať spolu s dostatkom tekutín. Akútne dávky do 30 g sú dobre tolerované za predpokladu, že sa spolu s nimi prijíma aj dostatok vody (v tomto prípade aspoň 500 ml). Pri použití psyllia na tvorbu stolice je dobrým východiskovým bodom denná dávka 15 g (dávka 5 g trikrát denne) a potom sa dávka môže upravovať nahor alebo nadol v závislosti od jeho účinkov na tvorbu stolice.

Upozornenie

Psyllium by sa malo okamžite zapiť vodou, pretože vloženie suchého prášku alebo šupiek psyllia do úst bez vody môže mať za následok vysatie a vysušenie slín s následným udusením.
Psyllium je možné kúpiť ako šupky alebo prášok. Z hľadiska zdravotných účinkov nie je medzi týmito formami žiadny významný rozdiel.  

Literatúra

  1. Cybulski KA, Lachaussée J, Kissileff HR. The threshold for satiating effectiveness of psyllium in a nutrient basePhysiol Behav. (1992)
  2. Gelissen IC, Brodie B, Eastwood MA. Effect of Plantago ovata (psyllium) husk and seeds on sterol metabolism: studies in normal and ileostomy subjectsAm J Clin Nutr. (1994)
  3. Frati-Munari AC, et al. Decrease in serum lipids, glycemia and body weight by Plantago psyllium in obese and diabetic patientsArch Invest Med (Mex). (1983)
  4. Digestibility and bulking effect of ispaghula husks in healthy humans.
  5. Chouinard LE. The role of psyllium fibre supplementation in treating irritable bowel syndromeCan J Diet Pract Res. (2011)
  6. Fleming V, Wade WE. A review of laxative therapies for treatment of chronic constipation in older adultsAm J Geriatr Pharmacother. (2010)
  7. Yu LL, Lutterodt H, Cheng Z. Beneficial health properties of psyllium and approaches to improve its functionalitiesAdv Food Nutr Res. (2009)
  8. Marlett JA, Fischer MH. A poorly fermented gel from psyllium seed husk increases excreta moisture and bile acid excretion in ratsJ Nutr. (2002)
  9. Marlett JA, Kajs TM, Fischer MH. An unfermented gel component of psyllium seed husk promotes laxation as a lubricant in humansAm J Clin Nutr. (2000)
  10. Al-Assaf S, et al. Molecular weight, tertiary structure, water binding and colon behaviour of ispaghula husk fibreProc Nutr Soc. (2003)
  11. Giacosa A, Rondanelli M. The right fiber for the right disease: an update on the psyllium seed husk and the metabolic syndromeJ Clin Gastroenterol. (2010)
  12. Pal S, Radavelli-Bagatini S. Effects of psyllium on metabolic syndrome risk factorsObes Rev. (2012)
  13. Burton-Freeman B, Davis PA, Schneeman BO. Plasma cholecystokinin is associated with subjective measures of satiety in womenAm J Clin Nutr. (2002)
  14. Karhunen LJ, et al. A psyllium fiber-enriched meal strongly attenuates postprandial gastrointestinal peptide release in healthy young adultsJ Nutr. (2010)
  15. Bergmann JF, et al. Correlation between echographic gastric emptying and appetite: influence of psylliumGut. (1992)
  16. Yao M, Roberts SB. Dietary energy density and weight regulationNutr Rev. (2001)
  17. Holt S, et al. Relationship of satiety to postprandial glycaemic, insulin and cholecystokinin responsesAppetite. (1992)
  18. Anderson JW, et al. Carbohydrate and fiber recommendations for individuals with diabetes: a quantitative assessment and meta-analysis of the evidenceJ Am Coll Nutr. (2004)
  19. Turnbull WH, Thomas HG. The effect of a Plantago ovata seed containing preparation on appetite variables, nutrient and energy intakeInt J Obes Relat Metab Disord. (1995)
  20. Delargy HJ, et al. Effects of amount and type of dietary fibre (soluble and insoluble) on short-term control of appetiteInt J Food Sci Nutr. (1997)
  21. Jun SC, et al. Anti-obesity effects of chitosan and psyllium husk with L-ascorbic acid in guinea pigsInt J Vitam Nutr Res. (2012)
  22. Prynne CJ, Southgate DA. The effects of a supplement of dietary fibre on faecal excretion by human subjectsBr J Nutr. (1979)
  23. Rodríguez-Morán M, Guerrero-Romero F, Lazcano-Burciaga G. Lipid- and glucose-lowering efficacy of Plantago Psyllium in type II diabetesJ Diabetes Complications. (1998)
  24. Sartore G, et al. The effects of psyllium on lipoproteins in type II diabetic patientsEur J Clin Nutr. (2009)
  25. de Bock M, et al. Psyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trialPLoS One. (2012)
  26. Wei ZH, et al. Time- and dose-dependent effect of psyllium on serum lipids in mild-to-moderate hypercholesterolemia: a meta-analysis of controlled clinical trialsEur J Clin Nutr. (2009)
  27. Matheson HB, Colón IS, Story JA. Cholesterol 7 alpha-hydroxylase activity is increased by dietary modification with psyllium hydrocolloid, pectin, cholesterol and cholestyramine in ratsJ Nutr. (1995)
  28. Buhman KK, et al. Dietary psyllium increases expression of ileal apical sodium-dependent bile acid transporter mRNA coordinately with dose-responsive changes in bile acid metabolism in ratsJ Nutr. (2000)
  29. Schneeman BO, Richter D. Changes in plasma and hepatic lipids, small intestinal histology and pancreatic enzyme activity due to aging and dietary fiber in ratsJ Nutr. (1993)
  30. Zhang JX, et al. Effect of oat bran on plasma cholesterol and bile acid excretion in nine subjects with ileostomiesAm J Clin Nutr. (1992)
  31. Marlett JA, et al. Mechanism of serum cholesterol reduction by oat branHepatology. (1994)
  32. Effects of psyllium hydrophilic mucilloid on LDL-cholesterol and bile acid synthesis in hypercholesterolemic men.
  33. Burke V, et al. Dietary protein and soluble fiber reduce ambulatory blood pressure in treated hypertensivesHypertension. (2001)
  34. Pal S, et al. The effects of 12-week psyllium fibre supplementation or healthy diet on blood pressure and arterial stiffness in overweight and obese individualsBr J Nutr. (2012)
  35. Sierra M, et al. Therapeutic effects of psyllium in type 2 diabetic patientsEur J Clin Nutr. (2002)
  36. Nuttall FQ. Dietary fiber in the management of diabetesDiabetes. (1993)
  37. Dow S, et al. Ultrahigh-viscosity hydroxypropylmethylcellulose blunts postprandial glucose after a breakfast meal in womenJ Am Coll Nutr. (2012)
  38. Jenkins DJ, et al. Dietary fibres, fibre analogues, and glucose tolerance: importance of viscosityBr Med J. (1978)
  39. Rendell M. Dietary treatment of diabetes mellitusN Engl J Med. (2000)
  40. Wolever TM, et al. Effect of method of administration of psyllium on glycemic response and carbohydrate digestibilityJ Am Coll Nutr. (1991)
  41. Watters K, Blaisdell P. Reduction of glycemic and lipid levels in db/db diabetic mice by psyllium plant fiberDiabetes. (1989)
  42. Galisteo M, et al. A diet supplemented with husks of Plantago ovata reduces the development of endothelial dysfunction, hypertension, and obesity by affecting adiponectin and TNF-alpha in obese Zucker ratsJ Nutr. (2005)
  43. Anderson JW, et al. Effects of psyllium on glucose and serum lipid responses in men with type 2 diabetes and hypercholesterolemiaAm J Clin Nutr. (1999)
  44. Bajorek SA, Morello CM. Effects of dietary fiber and low glycemic index diet on glucose control in subjects with type 2 diabetes mellitusAnn Pharmacother. (2010)
  45. Khossousi A, et al. The acute effects of psyllium on postprandial lipaemia and thermogenesis in overweight and obese menBr J Nutr. (2008)
  46. Cicero AF, et al. Different effect of psyllium and guar dietary supplementation on blood pressure control in hypertensive overweight patients: a six-month, randomized clinical trialClin Exp Hypertens. (2007)
  47. Ziai SA, et al. Psyllium decreased serum glucose and glycosylated hemoglobin significantly in diabetic outpatientsJ Ethnopharmacol. (2005)
  48. Vuksan V, et al. Viscosity rather than quantity of dietary fibre predicts cholesterol-lowering effect in healthy individualsBr J Nutr. (2011)
  49. Tai ES, et al. A study to assess the effect of dietary supplementation with soluble fibre (Minolest) on lipid levels in normal subjects with hypercholesterolaemiaAnn Acad Med Singapore. (1999)
  50. Kazmi SA, et al. Influence of sibutramine, orlistat and Ispaghula in reducing body weight and total body fat content in obese individualsJ Ayub Med Coll Abbottabad. (2009)
  51. Song YJ, et al. Soluble dietary fibre improves insulin sensitivity by increasing muscle GLUT-4 content in stroke-prone spontaneously hypertensive ratsClin Exp Pharmacol Physiol. (2000)
  52. Venter CS, Vorster HH, Van der Nest DG. Comparison between physiological effects of konjac-glucomannan and propionate in baboons fed „Western“ dietsJ Nutr. (1990)
  53. Togawa N, et al. Gene expression analysis of the liver and skeletal muscle of psyllium-treated miceBr J Nutr. (2012)
  54. Pollet A, et al. In vitro fermentation of arabinoxylan oligosaccharides and low molecular mass arabinoxylans with different structural properties from wheat (Triticum aestivum L.) bran and psyllium (Plantago ovata Forsk) seed huskJ Agric Food Chem. (2012)
  55. Marlett JA, Fischer MH. The active fraction of psyllium seed huskProc Nutr Soc. (2003)
  56. Edwards S, et al. Primary structure of arabinoxylans of ispaghula husk and wheat branProc Nutr Soc. (2003)
  57. Kaur A, et al. In vitro batch fecal fermentation comparison of gas and short-chain fatty acid production using „slowly fermentable“ dietary fibersJ Food Sci. (2011)
  58. Mortensen PB, et al. Colonic fermentation of ispaghula, wheat bran, glucose, and albumin to short-chain fatty acids and ammonia evaluated in vitro in 50 subjectsJPEN J Parenter Enteral Nutr. (1992)
  59. Psyllium and methylcellulose fermentation properties in relation to insoluble and soluble fiber standards.
  60. Bourquin LD, et al. Fermentation of dietary fibre by human colonic bacteria: disappearance of, short-chain fatty acid production from, and potential water-holding capacity of, various substratesScand J Gastroenterol. (1993)
  61. Timm DA, et al. Wheat dextrin, psyllium, and inulin produce distinct fermentation patterns, gas volumes, and short-chain fatty acid profiles in vitroJ Med Food. (2010)
  62. Al-Khaldi SF, Martin SA, Prakash L. Fermentation of fenugreek fiber, psyllium husk, and wheat bran by Bacteroides ovatus V975Curr Microbiol. (1999)
  63. Fernández-Bañares F, et al. Randomized clinical trial of Plantago ovata seeds (dietary fiber) as compared with mesalamine in maintaining remission in ulcerative colitis. Spanish Group for the Study of Crohn’s Disease and Ulcerative Colitis (GETECCU)Am J Gastroenterol. (1999)
  64. Harvey RF, Pomare EW, Heaton KW. Effects of increased dietary fibre on intestinal transitLancet. (1973)
  65. Spiller GA, et al. Bulk laxative efficacy of a psyllium seed hydrocolloid and of a mixture of cellulose and pectinJ Clin Pharmacol. (1979)
  66. Stevens J, et al. Comparison of the effects of psyllium and wheat bran on gastrointestinal transit time and stool characteristicsJ Am Diet Assoc. (1988)
  67. The role of dietary fibre in the human colon.
  68. Tomlin J, Lowis C, Read NW. Investigation of normal flatus production in healthy volunteersGut. (1991)
  69. Bolin TD, Stanton RA. Flatus emission patterns and fibre intakeEur J Surg Suppl. (1998)
  70. Gonlachanvit S, et al. Inhibitory actions of a high fibre diet on intestinal gas transit in healthy volunteersGut. (2004)
  71. Marthinsen D, Fleming SE. Excretion of breath and flatus gases by humans consuming high-fiber dietsJ Nutr. (1982)
  72. Wolever TM, et al. Guar, but not psyllium, increases breath methane and serum acetate concentrations in human subjectsAm J Clin Nutr. (1992)
  73. Marteau P, et al. Digestibility and bulking effect of ispaghula husks in healthy humansGut. (1994)
  74. Levitt MD, Furne J, Olsson S. The relation of passage of gas an abdominal bloating to colonic gas productionAnn Intern Med. (1996)
  75. Bond JH, Levitt MD. Effect of dietary fiber on intestinal gas production and small bowel transit time in manAm J Clin Nutr. (1978)
  76. Fernandez R, Phillips SF. Components of fiber bind iron in vitroAm J Clin Nutr. (1982)
  77. Fernandez R, Phillips SF. Components of fiber impair iron absorption in the dogAm J Clin Nutr. (1982)
  78. Rossander L. Effect of dietary fiber on iron absorption in manScand J Gastroenterol Suppl. (1987)
  79. Dennison BA, Levine DM. Randomized, double-blind, placebo-controlled, two-period crossover clinical trial of psyllium fiber in children with hypercholesterolemiaJ Pediatr. (1993)
  80. Anderson JW, et al. Cholesterol-lowering effects of psyllium hydrophilic mucilloid for hypercholesterolemic menArch Intern Med. (1988)
  81. Bell LP, et al. Cholesterol-lowering effects of soluble-fiber cereals as part of a prudent diet for patients with mild to moderate hypercholesterolemiaAm J Clin Nutr. (1990)
  82. Younes H, et al. Effects of two fermentable carbohydrates (inulin and resistant starch) and their combination on calcium and magnesium balance in ratsBr J Nutr. (2001)
  83. Holloway L, et al. Effects of oligofructose-enriched inulin on intestinal absorption of calcium and magnesium and bone turnover markers in postmenopausal womenBr J Nutr. (2007)
  84. Trinidad TP, Wolever TM, Thompson LU. Availability of calcium for absorption in the small intestine and colon from diets containing available and unavailable carbohydrates: an in vitro assessmentInt J Food Sci Nutr. (1996)
  85. Dikeman CL, Murphy MR, Fahey GC Jr. Dietary fibers affect viscosity of solutions and simulated human gastric and small intestinal digestaJ Nutr. (2006)
  86. Floating drug delivery systems: A review.
  87. Ram HN, et al. Formulation and evaluation of floating tablets of liquorice extractPharmacognosy Res. (2010)
  88. Chavanpatil M, et al. Development of sustained release gastroretentive drug delivery system for ofloxacin: in vitro and in vivo evaluationInt J Pharm. (2005)
  89. Chavanpatil MD, et al. Novel sustained release, swellable and bioadhesive gastroretentive drug delivery system for ofloxacinInt J Pharm. (2006)
  90. Asnaashari S, et al. Preparation and evaluation of novel metronidazole sustained release and floating matrix tabletsPharm Dev Technol. (2011)
  91. Garg R, Gupta GD. Preparation and evaluation of gastroretentive floating tablets of SilymarinChem Pharm Bull (Tokyo). (2009)
  92. Morita T, et al. Psyllium shifts the fermentation site of high-amylose cornstarch toward the distal colon and increases fecal butyrate concentration in ratsJ Nutr. (1999)
  93. Hoffman D. Psyllium: keeping this boon for patients from becoming a bane for providersJ Fam Pract. (2006)
  94. Malo JL, et al. Prevalence of occupational asthma and immunologic sensitization to psyllium among health personnel in chronic care hospitalsAm Rev Respir Dis. (1990)
  95. Cartier A, Malo JL, Dolovich J. Occupational asthma in nurses handling psylliumClin Allergy. (1987)
  96. Machado L, Stålenheim G. Respiratory symptoms in ispaghula-allergic nurses after oral challenge with ispaghula suspensionAllergy. (1984)
  97. Machado L, Zetterström O, Fagerberg E. Occupational allergy in nurses to a bulk laxativeAllergy. (1979)
  98. Gauss WF, Alarie JP, Karol MH. Workplace allergenicity of a psyllium-containing bulk laxativeAllergy. (1985)
  99. Ispagula powder: an allergen in the work environment.
  100. McConnochie K, Edwards JH, Fifield R. Ispaghula sensitization in workers manufacturing a bulk laxativeClin Exp Allergy. (1990)
  101. Arlian LG, et al. Antigenic and allergenic analysis of psyllium seed componentsJ Allergy Clin Immunol. (1992)
  102. Khalili B, Bardana EJ Jr, Yunginger JW. Psyllium-associated anaphylaxis and death: a case report and review of the literatureAnn Allergy Asthma Immunol. (2003)
  103. James JM, et al. Anaphylactic reactions to a psyllium-containing cerealJ Allergy Clin Immunol. (1991)

Medicínske upozornenie!

Anatómia antioxidanty autoimunita bezlepková diéta bolesť chrbát COVID-19 CRP cvičenie Deep Dive DEEP DIVE – ANATOMY Deep Dive – Literature dezinfekcia fajčenie Fyzika IBD infekčné choroby karnitín karotenoidy ketogénna diéta koenzým Q10 kosti koža káva kĺby Literatúra mozog mužské zdravie obezita omega-3 pamäť podcast poznávacie funkcie probiotiká psoriáza rakovina stredomorská diéta terpény vitamín C vitamín D vitamín E vitiligo xantíny zelený čaj ženské zdravie