Uridín

Literatúra

  1. Cognitex supplementation in elderly adults with memory complaints: an uncontrolled open label trial.
  2. Yamamoto T, et al. Effect of beer on the plasma concentrations of uridine and purine bases. Metabolism. (2002)
  3. Almeida C, et al. Composition of beer by 1H NMR spectroscopy: effects of brewing site and date of production. J Agric Food Chem. (2006)
  4. Sugawara M, et al. Profile of nucleotides and nucleosides of human milk. J Nutr Sci Vitaminol (Tokyo). (1995)
  5. Thorell L, Sjöberg LB, Hernell O. Nucleotides in human milk: sources and metabolism by the newborn infant. Pediatr Res. (1996)
  6. Wurtman RJ. Synapse formation and cognitive brain development: effect of docosahexaenoic acid and other dietary constituents. Metabolism. (2008)
  7. Jonas DA, et al. Safety considerations of DNA in food. Ann Nutr Metab. (2001)
  8. Ka T, et al. Effects of allopurinol on beer-induced increases in plasma concentrations and urinary excretion of purine bases (uric acid, hypoxanthine, and xanthine). Horm Metab Res. (2006)
  9. Inokuchi T, et al. Effects of allopurinol on beer-induced increases in plasma concentrations of purine bases and uridine. Nucleosides Nucleotides Nucleic Acids. (2008)
  10. Shetlar MD, Hom K, Venditto VJ. Photohydrate-Mediated Reactions of Uridine, 2′-Deoxyuridine and 2′-Deoxycytidine with Amines at Near Neutral pH. Photochem Photobiol. (2013)
  11. Stene R, Spector R. Effect of a 400-kilocalorie carbohydrate diet on human plasma uridine and hypoxanthine concentrations. Biochem Med Metab Biol. (1987)
  12. Eells JT, Spector R, Huntoon S. Nucleoside and oxypurine homeostasis in adult rabbit cerebrospinal fluid and plasma. J Neurochem. (1984)
  13. Weinberg ME, et al. Enhanced uridine bioavailability following administration of a triacetyluridine-rich nutritional supplement. PLoS One. (2011)
  14. Pizzorno G, et al. Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update. Biochim Biophys Acta. (2002)
  15. van Groeningen CJ, et al. Clinical and pharmacologic study of orally administered uridine. J Natl Cancer Inst. (1991)
  16. Venhoff N, et al. Uridine pharmacokinetics of mitocnol, a sugar cane extract. AIDS. (2005)
  17. Ashour OM, Naguib FN, el Kouni MH. 5-(m-Benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2′,3′,5′-tri-O-acetyluridine, a prodrug of uridine, as modulators of plasma uridine concentration. Implications for chemotherapy. Biochem Pharmacol. (1996)
  18. Acylated uridine and cytidine and uses thereof.
  19. Ashour OM, et al. Effect of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on plasma concentration of uridine released from 2′,3′,5′-tri-O-acetyluridine, a prodrug of uridine: relevance to uridine rescue in chemotherapy. Cancer Chemother Pharmacol. (2000)
  20. Connolly GP, Duley JA. Uridine and its nucleotides: biological actions, therapeutic potentials. Trends Pharmacol Sci. (1999)
  21. STUDIES ON THE ORIGIN OF PYRIMIDINES FOR BIOSYNTHESIS OF NEURAL RNA IN THE RAT.
  22. Cornford EM, Oldendorf WH. Independent blood-brain barrier transport systems for nucleic acid precursors. Biochim Biophys Acta. (1975)
  23. Baldwin SA, et al. The equilibrative nucleoside transporter family, SLC29. Pflugers Arch. (2004)
  24. Pastor-Anglada M, Felipe A, Casado FJ. Transport and mode of action of nucleoside derivatives used in chemical and antiviral therapies. Trends Pharmacol Sci. (1998)
  25. Gray JH, Owen RP, Giacomini KM. The concentrative nucleoside transporter family, SLC28. Pflugers Arch. (2004)
  26. Kong W, Engel K, Wang J. Mammalian nucleoside transporters. Curr Drug Metab. (2004)
  27. Podgorska M, Kocbuch K, Pawelczyk T. Recent advances in studies on biochemical and structural properties of equilibrative and concentrative nucleoside transporters. Acta Biochim Pol. (2005)
  28. Gibellini F, Smith TK. The Kennedy pathway–De novo synthesis of phosphatidylethanolamine and phosphatidylcholine. IUBMB Life. (2010)
  29. Vance JE, Vance DE. Phospholipid biosynthesis in mammalian cells. Biochem Cell Biol. (2004)
  30. Fagone P, Jackowski S. Phosphatidylcholine and the CDP-choline cycle. Biochim Biophys Acta. (2013)
  31. Aoyama C, Liao H, Ishidate K. Structure and function of choline kinase isoforms in mammalian cells. Prog Lipid Res. (2004)
  32. Wu G, Vance DE. Choline kinase and its function. Biochem Cell Biol. (2010)
  33. Jansen SM, et al. Biosynthesis of phosphatidylcholine from a phosphocholine precursor pool derived from the late endosomal/lysosomal degradation of sphingomyelin. J Biol Chem. (2001)
  34. Millington WR, Wurtman RJ. Choline administration elevates brain phosphorylcholine concentrations. J Neurochem. (1982)
  35. Jackowski S, Fagone P. CTP: Phosphocholine cytidylyltransferase: paving the way from gene to membrane. J Biol Chem. (2005)
  36. Cornell RB, Northwood IC. Regulation of CTP:phosphocholine cytidylyltransferase by amphitropism and relocalization. Trends Biochem Sci. (2000)
  37. Kent C. Regulatory enzymes of phosphatidylcholine biosynthesis: a personal perspective. Biochim Biophys Acta. (2005)
  38. Choy PC, Paddon HB, Vance DE. An increase in cytoplasmic CTP accelerates the reaction catalyzed by CTP:phosphocholine cytidylyltransferase in poliovirus-infected HeLa cells. J Biol Chem. (1980)
  39. Vance DE. Boehringer Mannheim Award lecture. Phosphatidylcholine metabolism: masochistic enzymology, metabolic regulation, and lipoprotein assembly. Biochem Cell Biol. (1990)
  40. Jamil H, Utal AK, Vance DE. Evidence that cyclic AMP-induced inhibition of phosphatidylcholine biosynthesis is caused by a decrease in cellular diacylglycerol levels in cultured rat hepatocytes. J Biol Chem. (1992)
  41. Baburina I, Jackowski S. Cellular responses to excess phospholipid. J Biol Chem. (1999)
  42. Cornell RB. Cholinephosphotransferase from mammalian sources. Methods Enzymol. (1992)
  43. The enzymatic formation of lecithin from cytidine diphosphate choline and D-1,2-diglyceride.
  44. Henneberry AL, Wistow G, McMaster CR. Cloning, genomic organization, and characterization of a human cholinephosphotransferase. J Biol Chem. (2000)
  45. Henneberry AL, McMaster CR. Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine. Biochem J. (1999)
  46. Horibata Y, Hirabayashi Y. Identification and characterization of human ethanolaminephosphotransferase1. J Lipid Res. (2007)
  47. Richardson UI, et al. Stimulation of CDP-choline synthesis by uridine or cytidine in PC12 rat pheochromocytoma cells. Brain Res. (2003)
  48. Araki W, Wurtman RJ. Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth. Proc Natl Acad Sci U S A. (1997)
  49. Savci V, Wurtman RJ. Effect of cytidine on membrane phospholipid synthesis in rat striatal slices. J Neurochem. (1995)
  50. G-Coviella IL, Wurtman RJ. Enhancement by cytidine of membrane phospholipid synthesis. J Neurochem. (1992)
  51. Wurtman RJ, et al. Effect of oral CDP-choline on plasma choline and uridine levels in humans. Biochem Pharmacol. (2000)
  52. Ulus IH, et al. Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release. Cell Mol Neurobiol. (2006)
  53. Cansev M, et al. Oral uridine-5′-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Brain Res. (2005)
  54. Agarwal N, et al. Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T. Bipolar Disord. (2010)
  55. Silveri MM, et al. Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR Biomed. (2008)
  56. Babb SM, et al. Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study. Psychopharmacology (Berl). (2002)
  57. Vance JE. Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids. J Lipid Res. (2008)
  58. Burnstock G. Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev. (2007)
  59. Van Poecke S, et al. Synthesis and P2Y₂ receptor agonist activities of uridine 5′-phosphonate analogues. Bioorg Med Chem. (2012)
  60. Weisman GA, et al. P2 receptors in health and disease. Biotechnol Genet Eng Rev. (2006)
  61. Erb L, et al. P2 receptors: intracellular signaling. Pflugers Arch. (2006)
  62. Pooler AM, et al. Uridine enhances neurite outgrowth in nerve growth factor-differentiated PC12 {corrected}. Neuroscience. (2005)
  63. Brunschweiger A, Müller CE. P2 receptors activated by uracil nucleotides–an update. Curr Med Chem. (2006)
  64. P2Y2 Nucleotide Receptors Expressed Heterologously in Sympathetic Neurons Inhibit Both N-Type Ca and M-Type K Currents.
  65. Dobolyi A, et al. Uridine function in the central nervous system. Curr Top Med Chem. (2011)
  66. Zhang Z, et al. P2Y(6) agonist uridine 5′-diphosphate promotes host defense against bacterial infection via monocyte chemoattractant protein-1-mediated monocytes/macrophages recruitment. J Immunol. (2011)
  67. Kim B, et al. Uridine 5′-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor. J Immunol. (2011)
  68. Harden TK, et al. Signalling and pharmacological properties of the P2Y receptor. Acta Physiol (Oxf). (2010)
  69. Illes P, Alexandre Ribeiro J. Molecular physiology of P2 receptors in the central nervous system. Eur J Pharmacol. (2004)
  70. Köles L, et al. P2 receptor signaling in neurons and glial cells of the central nervous system. Adv Pharmacol. (2011)
  71. Erb L, et al. An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction. J Cell Biol. (2001)
  72. Bagchi S, et al. The P2Y2 nucleotide receptor interacts with alphav integrins to activate Go and induce cell migration. J Biol Chem. (2005)
  73. Arthur DB, Akassoglou K, Insel PA. P2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation. Proc Natl Acad Sci U S A. (2005)
  74. Weisman GA, et al. Neuroprotective roles of the P2Y(2) receptor. Purinergic Signal. (2012)
  75. Selkoe DJ. Alzheimer’s disease is a synaptic failure. Science. (2002)
  76. Terry RD. Alzheimer’s disease and the aging brain. J Geriatr Psychiatry Neurol. (2006)
  77. Spires-Jones TL, et al. Impaired spine stability underlies plaque-related spine loss in an Alzheimer’s disease mouse model. Am J Pathol. (2007)
  78. Wurtman RJ, et al. Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase formation of brain synapses. Nutr Rev. (2010)
  79. Alvarez VA, Sabatini BL. Anatomical and physiological plasticity of dendritic spines. Annu Rev Neurosci. (2007)
  80. Arellano JI, et al. Non-synaptic dendritic spines in neocortex. Neuroscience. (2007)
  81. Harms KJ, Dunaevsky A. Dendritic spine plasticity: looking beyond development. Brain Res. (2007)
  82. Wurtman RJ, et al. Use of phosphatide precursors to promote synaptogenesis. Annu Rev Nutr. (2009)
  83. Wurtman RJ, et al. Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. Brain Res. (2006)
  84. The efficacy of Souvenaid in mild Alzheimer’s disease: a randomized, controlled, double-blind, parallel group, multi-centre, multi-country clinical trial.
  85. Neary JT, et al. Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells. Trends Neurosci. (1996)
  86. Boglári G, Szeberényi J. Nerve growth factor in combination with second messenger analogues causes neuronal differentiation of PC12 cells expressing a dominant inhibitory Ras protein without inducing activation of extracellular signal-regulated kinases. Eur J Neurosci. (2001)
  87. Chuang HH, et al. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature. (2001)
  88. Rathbone MP, et al. Trophic effects of purines in neurons and glial cells. Prog Neurobiol. (1999)
  89. Wang L, et al. Dietary uridine-5′-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats. J Mol Neurosci. (2005)
  90. Lee V, Trojanowski JQ, Schlaepfer WW. Induction of neurofilament triplet proteins in PC12 cells by nerve growth factor. Brain Res. (1982)
  91. Broersen LM, et al. A Specific Multi-Nutrient Diet Reduces Alzheimer-Like Pathology in Young Adult AβPPswe/PS1dE9 Mice. J Alzheimers Dis. (2012)
  92. Open-Label Uridine for Treatment of Depressed Adolescents with Bipolar Disorder.
  93. Jensen JE, et al. Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients. Exp Clin Psychopharmacol. (2008)
  94. Krylova IB, et al. Effect of uridine on energy metabolism, LPO, and antioxidant system in the myocardium under conditions of acute coronary insufficiency. Bull Exp Biol Med. (2012)
  95. Nolan D, et al. Mitochondrial DNA depletion and morphologic changes in adipocytes associated with nucleoside reverse transcriptase inhibitor therapy. AIDS. (2003)
  96. McComsey GA, et al. Uridine supplementation in the treatment of HIV lipoatrophy: results of ACTG 5229. AIDS. (2010)
  97. McComsey GA, et al. Mitochondrial function, inflammation, fat and bone in HIV lipoatrophy: randomized study of uridine supplementation or switch to tenofovir. Antivir Ther. (2012)
  98. Sutinen J, et al. Uridine supplementation for the treatment of antiretroviral therapy-associated lipoatrophy: a randomized, double-blind, placebo-controlled trial. Antivir Ther. (2007)
  99. Choi JH, Ji YG, Lee DH. Uridine Triphosphate Increases Proliferation of Human Cancerous Pancreatic Duct Epithelial Cells by Activating P2Y2 Receptor. Pancreas. (2013)
  100. Silver AF, Chase HB. The incorporation of tritiated uridine in hair germ and dermal papilla during dormancy (telogen) and activation (early anagen). J Invest Dermatol. (1977)
  101. Potten CS, Jessup BA, Croxson MB. Incorporation of tritiated thymidine into the skin and hair follicles. II. Daily fluctuations in 3 H-TdR and 3 H-UR levels. Cell Tissue Kinet. (1971)
  102. Sims RT. The incorporation of 3H-cytidine into the differentiating cells of the hair cortex. J Anat. (1968)
  103. Greig AV, Linge C, Burnstock G. Purinergic receptors are part of a signalling system for proliferation and differentiation in distinct cell lineages in human anagen hair follicles. Purinergic Signal. (2008)
  104. Dixon CJ, et al. Regulation of epidermal homeostasis through P2Y2 receptors. Br J Pharmacol. (1999)
  105. Greig AV, et al. Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes. J Invest Dermatol. (2003)
  106. Lee WK, et al. Purinoceptor-mediated calcium mobilization and proliferation in HaCaT keratinocytes. J Dermatol Sci. (2001)
  107. Babb SM, et al. Oral choline increases choline metabolites in human brain. Psychiatry Res. (2004)