Tripterygium wilfordii

Literatúra

  1. Salminen A, et al. Celastrol: Molecular targets of Thunder God Vine. Biochem Biophys Res Commun. (2010)
  2. Zhang Y, et al. Therapeutic effects of total alkaloids of Tripterygium wilfordii Hook f. on collagen-induced arthritis in rats. J Ethnopharmacol. (2012)
  3. Canter PH, Lee HS, Ernst E. A systematic review of randomised clinical trials of Tripterygium wilfordii for rheumatoid arthritis. Phytomedicine. (2006)
  4. Huang M, et al. Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway. Mol Cancer Ther. (2012)
  5. Zhao JW, et al. Demethylzeylasteral exhibits strong inhibition towards UDP-glucuronosyltransferase (UGT) 1A6 and 2B7. Molecules. (2012)
  6. Fang W, et al. Biological activity and safety of Tripterygium extract prepared by sodium carbonate extraction. Molecules. (2012)
  7. Yang H, et al. Celastrol, a triterpene extracted from the Chinese „Thunder of God Vine,“ is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. (2006)
  8. Inhibition of NF-κB activation through targeting IκB kinase by celastrol, a quinone methide triterpenoid.
  9. Sreeramulu S, et al. Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrol. Angew Chem Int Ed Engl. (2009)
  10. Anticancer treatment using triptolide prodrugs.
  11. Li W, et al. Characterization of triptolide hydroxylation by cytochrome P450 in human and rat liver microsomes. Xenobiotica. (2008)
  12. Papakostas D, et al. Nanoparticles in dermatology. Arch Dermatol Res. (2011)
  13. Xue M, et al. Anti-inflammatory effects and hepatotoxicity of Tripterygium-loaded solid lipid nanoparticles on adjuvant-induced arthritis in rats. Phytomedicine. (2012)
  14. Liu M, et al. Anti-inflammatory effects of triptolide loaded poly(D,L-lactic acid) nanoparticles on adjuvant-induced arthritis in rats. J Ethnopharmacol. (2005)
  15. Xue M, et al. Protective effects of tripterygium glycoside-loaded solid lipid nanoparticles on male reproductive toxicity in rats. Arzneimittelforschung. (2011)
  16. Mei Z, et al. The research on the anti-inflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticle. Pharmacol Res. (2005)
  17. Pharmacologic inhibitors of IκB kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo.
  18. Sethi G, et al. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation. Blood. (2007)
  19. Salminen A, et al. Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90. Immunol Lett. (2008)
  20. Westerheide SD, et al. Celastrols as inducers of the heat shock response and cytoprotection. J Biol Chem. (2004)
  21. Hsp70 promotes TNF-mediated apoptosis by binding IKKγ and impairing NF-κB survival signaling.
  22. Kim Y, et al. Celastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-allergic effect. Eur J Pharmacol. (2009)
  23. Wang Y, Jia L, Wu CY. Triptolide inhibits the differentiation of Th17 cells and suppresses collagen-induced arthritis. Scand J Immunol. (2008)
  24. Chen P, et al. Modulatory effect of triptolide on differentiation of human Th17 cells. Zhongguo Zhong Yao Za Zhi. (2011)
  25. Wu C, et al. Triptolide protects mice from ischemia/reperfusion injury by inhibition of IL-17 production. Int Immunopharmacol. (2011)
  26. Rose-John S, et al. Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease. Curr Pharm Des. (2009)
  27. Ivanov II, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. (2006)
  28. Nishihara M, et al. IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state. Int Immunol. (2007)
  29. Li Y, et al. Triptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6/STAT3 signaling pathway and down-regulation of IL-17. Mol Immunol. (2010)
  30. Trott A, et al. Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. Mol Biol Cell. (2008)
  31. Xue X, et al. Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity. Toxicol Lett. (2011)
  32. Ye X, et al. Effects of cytochrome P4503A inducer dexamethasone on the metabolism and toxicity of triptolide in rat. Toxicol Lett. (2010)
  33. Zhang Z, et al. The targeting of 14-succinate triptolide-lysozyme conjugate to proximal renal tubular epithelial cells. Biomaterials. (2009)
  34. Chadli A, et al. Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23. J Biol Chem. (2010)
  35. Liu J, et al. Effects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell lines. Phytomedicine. (2009)
  36. Chen D, et al. Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells. Biochem Pharmacol. (2005)
  37. Lee JH, et al. Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling. Apoptosis. (2012)
  38. Krantic S, et al. Apoptosis-inducing factor: a matter of neuron life and death. Prog Neurobiol. (2007)
  39. Zhou R, et al. (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo. Int Immunopharmacol. (2005)
  40. Grzegorzewska AE, et al. Disseminated cutaneous Kaposi sarcoma in a patient receiving triptolide/tripdiolide for rheumatoid arthritis. Med Sci Monit. (2012)