Tripterygium wilfordii


  1. Salminen A, et al. Celastrol: Molecular targets of Thunder God VineBiochem Biophys Res Commun. (2010)
  2. Zhang Y, et al. Therapeutic effects of total alkaloids of Tripterygium wilfordii Hook f. on collagen-induced arthritis in ratsJ Ethnopharmacol. (2012)
  3. Canter PH, Lee HS, Ernst E. A systematic review of randomised clinical trials of Tripterygium wilfordii for rheumatoid arthritisPhytomedicine. (2006)
  4. Huang M, et al. Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathwayMol Cancer Ther. (2012)
  5. Zhao JW, et al. Demethylzeylasteral exhibits strong inhibition towards UDP-glucuronosyltransferase (UGT) 1A6 and 2B7Molecules. (2012)
  6. Fang W, et al. Biological activity and safety of Tripterygium extract prepared by sodium carbonate extractionMolecules. (2012)
  7. Yang H, et al. Celastrol, a triterpene extracted from the Chinese „Thunder of God Vine,“ is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude miceCancer Res. (2006)
  8. Inhibition of NF-κB activation through targeting IκB kinase by celastrol, a quinone methide triterpenoid.
  9. Sreeramulu S, et al. Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrolAngew Chem Int Ed Engl. (2009)
  10. Anticancer treatment using triptolide prodrugs.
  11. Li W, et al. Characterization of triptolide hydroxylation by cytochrome P450 in human and rat liver microsomesXenobiotica. (2008)
  12. Papakostas D, et al. Nanoparticles in dermatologyArch Dermatol Res. (2011)
  13. Xue M, et al. Anti-inflammatory effects and hepatotoxicity of Tripterygium-loaded solid lipid nanoparticles on adjuvant-induced arthritis in ratsPhytomedicine. (2012)
  14. Liu M, et al. Anti-inflammatory effects of triptolide loaded poly(D,L-lactic acid) nanoparticles on adjuvant-induced arthritis in ratsJ Ethnopharmacol. (2005)
  15. Xue M, et al. Protective effects of tripterygium glycoside-loaded solid lipid nanoparticles on male reproductive toxicity in ratsArzneimittelforschung. (2011)
  16. Mei Z, et al. The research on the anti-inflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticlePharmacol Res. (2005)
  17. Pharmacologic inhibitors of IκB kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo.
  18. Sethi G, et al. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activationBlood. (2007)
  19. Salminen A, et al. Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90Immunol Lett. (2008)
  20. Westerheide SD, et al. Celastrols as inducers of the heat shock response and cytoprotectionJ Biol Chem. (2004)
  21. Hsp70 promotes TNF-mediated apoptosis by binding IKKγ and impairing NF-κB survival signaling.
  22. Kim Y, et al. Celastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-allergic effectEur J Pharmacol. (2009)
  23. Wang Y, Jia L, Wu CY. Triptolide inhibits the differentiation of Th17 cells and suppresses collagen-induced arthritisScand J Immunol. (2008)
  24. Chen P, et al. Modulatory effect of triptolide on differentiation of human Th17 cellsZhongguo Zhong Yao Za Zhi. (2011)
  25. Wu C, et al. Triptolide protects mice from ischemia/reperfusion injury by inhibition of IL-17 productionInt Immunopharmacol. (2011)
  26. Rose-John S, et al. Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel diseaseCurr Pharm Des. (2009)
  27. Ivanov II, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsCell. (2006)
  28. Nishihara M, et al. IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady stateInt Immunol. (2007)
  29. Li Y, et al. Triptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6/STAT3 signaling pathway and down-regulation of IL-17Mol Immunol. (2010)
  30. Trott A, et al. Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted moleculeMol Biol Cell. (2008)
  31. Xue X, et al. Knockout of hepatic P450 reductase aggravates triptolide-induced toxicityToxicol Lett. (2011)
  32. Ye X, et al. Effects of cytochrome P4503A inducer dexamethasone on the metabolism and toxicity of triptolide in ratToxicol Lett. (2010)
  33. Zhang Z, et al. The targeting of 14-succinate triptolide-lysozyme conjugate to proximal renal tubular epithelial cellsBiomaterials. (2009)
  34. Chadli A, et al. Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23J Biol Chem. (2010)
  35. Liu J, et al. Effects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell linesPhytomedicine. (2009)
  36. Chen D, et al. Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cellsBiochem Pharmacol. (2005)
  37. Lee JH, et al. Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signalingApoptosis. (2012)
  38. Krantic S, et al. Apoptosis-inducing factor: a matter of neuron life and deathProg Neurobiol. (2007)
  39. Zhou R, et al. (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivoInt Immunopharmacol. (2005)
  40. Grzegorzewska AE, et al. Disseminated cutaneous Kaposi sarcoma in a patient receiving triptolide/tripdiolide for rheumatoid arthritisMed Sci Monit. (2012)