Polypodium leucotomos


  1. Baumann LS. Less-known botanical cosmeceuticalsDermatol Ther. (2007)
  2. Sempere-Ortells JM, et al. Anapsos (Polypodium leucotomos) modulates lymphoid cells and the expression of adhesion moleculesPharmacol Res. (2002)
  3. Padilla HC, Laínez H, Pacheco JA. A new agent (hydrophilic fraction of polypodium leucotomos) for management of psoriasisInt J Dermatol. (1974)
  4. Manna SK, et al. Calagualine inhibits nuclear transcription factors-kappaB activated by various inflammatory and tumor promoting agentsCancer Lett. (2003)
  5. Gombau L, et al. Polypodium leucotomos extract: antioxidant activity and dispositionToxicol In Vitro. (2006)
  6. Garcia F, et al. Phenolic components and antioxidant activity of Fernblock, an aqueous extract of the aerial parts of the fern Polypodium leucotomosMethods Find Exp Clin Pharmacol. (2006)
  7. Alvarez XA, et al. Double-blind, randomized, placebo-controlled pilot study with anapsos in senile dementia: effects on cognition, brain bioelectrical activity and cerebral hemodynamicsMethods Find Exp Clin Pharmacol. (2000)
  8. Navarro-Zorraquino M, et al. Pharmacological immunomodulation of surgical traumaJ Invest Surg. (2007)
  9. López-Abán J, et al. Immunomodulation of the response to excretory/secretory antigens of Fasciola hepatica by Anapsos in Balb/C mice and rat alveolar macrophagesJ Parasitol. (2007)
  10. Solivellas BM, Martín TC. Polypodium leucotomos Extract use to prevent and reduce the risk of infectious diseases in high performance athletesInfect Drug Resist. (2012)
  11. Rodríguez-Yanes E, et al. Polypodium leucotomos decreases UV-induced epidermal cell proliferation and enhances p53 expression and plasma antioxidant capacity in hairless miceExp Dermatol. (2012)
  12. Zattra E, et al. Polypodium leucotomos extract decreases UV-induced Cox-2 expression and inflammation, enhances DNA repair, and decreases mutagenesis in hairless miceAm J Pathol. (2009)
  13. Kastan MB. Wild-type p53: tumors can’t stand itCell. (2007)
  14. Komarova EA, et al. p53 is a suppressor of inflammatory response in miceFASEB J. (2005)
  15. Smith ML, Fornace AJ Jr. p53-mediated protective responses to UV irradiationProc Natl Acad Sci U S A. (1997)
  16. Philips N, et al. Beneficial regulation of matrixmetalloproteinases and their inhibitors, fibrillar collagens and transforming growth factor-beta by Polypodium leucotomos, directly or in dermal fibroblasts, ultraviolet radiated fibroblasts, and melanoma cellsArch Dermatol Res. (2009)
  17. González S, Pathak MA. Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema and skin photosensitization by polypodium leucotomosPhotodermatol Photoimmunol Photomed. (1996)
  18. Emanuel P, Scheinfeld N. A review of DNA repair and possible DNA-repair adjuvants and selected natural anti-oxidantsDermatol Online J. (2007)
  19. Fosslien E. Review: molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesisAnn Clin Lab Sci. (2001)
  20. Siscovick JR, et al. Polypodium leucotomos inhibits ultraviolet B radiation-induced immunosuppressionPhotodermatol Photoimmunol Photomed. (2008)
  21. Jańczyk A, et al. A Polypodium leucotomos extract inhibits solar-simulated radiation-induced TNF-alpha and iNOS expression, transcriptional activation and apoptosisExp Dermatol. (2007)
  22. Ramírez-Bosca A, et al. Polypodium leucotomos extract in atopic dermatitis: a randomized, double-blind, placebo-controlled, multicenter trialActas Dermosifiliogr. (2012)
  23. Whitton ME, et al. Interventions for vitiligoCochrane Database Syst Rev. (2010)
  24. Middelkamp-Hup MA, et al. Treatment of vitiligo vulgaris with narrow-band UVB and oral Polypodium leucotomos extract: a randomized double-blind placebo-controlled studyJ Eur Acad Dermatol Venereol. (2007)
  25. Tanew A, et al. Oral administration of a hydrophilic extract of Polypodium leucotomos for the prevention of polymorphic light eruptionJ Am Acad Dermatol. (2012)
  26. Caccialanza M, et al. Photoprotective activity of oral polypodium leucotomos extract in 25 patients with idiopathic photodermatosesPhotodermatol Photoimmunol Photomed. (2007)
  27. Caccialanza M, Recalcati S, Piccinno R. Oral polypodium leucotomos extract photoprotective activity in 57 patients with idiopathic photodermatosesG Ital Dermatol Venereol. (2011)
  28. Middelkamp-Hup MA, et al. Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skinJ Am Acad Dermatol. (2004)
  29. Mulero M, et al. Polypodium leucotomos extract inhibits glutathione oxidation and prevents Langerhans cell depletion induced by UVB/UVA radiation in a hairless rat modelExp Dermatol. (2008)
  30. González S, et al. Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skinPhotodermatol Photoimmunol Photomed. (1997)
  31. Berneburg M, et al. Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletionJ Biol Chem. (1999)
  32. Villa A, et al. Decrease of ultraviolet A light-induced „common deletion“ in healthy volunteers after oral Polypodium leucotomos extract supplement in a randomized clinical trialJ Am Acad Dermatol. (2010)
  33. Breithaupt AD, Jacob SE. Subacute cutaneous lupus erythematosus: a case report of Polypodium leucotomos as an adjuvant therapyCutis. (2012)