Bakopa drobnolistá – Bacopa monnieri


  1. Neuropsychopharmacological effects of the Ayurvedic nootropic Bacopa monniera Linn. (Brahmi).
  2. Ven Murthy MR, et al. Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandhaCent Nerv Syst Agents Med Chem. (2010)
  3. Shinomol GK, Muralidhara, Bharath MM. Exploring the role of “Brahmi” (Bocopa monnieri and Centella asiatica) in brain function and therapyRecent Pat Endocr Metab Immune Drug Discov. (2011)
  4. Singh RH, Narsimhamurthy K, Singh G. Neuronutrient impact of Ayurvedic Rasayana therapy in brain agingBiogerontology. (2008)
  5. Mukherjee S, et al. Evaluation of comparative free-radical quenching potential of Brahmi (Bacopa monnieri) and Mandookparni (Centella asiatica)Ayu. (2011)
  6. Russo A, Borrelli F. Bacopa monniera, a reputed nootropic plant: an overviewPhytomedicine. (2005)
  7. Shinomol GK, Muralidhara. Bacopa monnieri modulates endogenous cytoplasmic and mitochondrial oxidative markers in prepubertal mice brainPhytomedicine. (2011)
  8. Chowdhuri DK, et al. Antistress effects of bacosides of Bacopa monnieri: modulation of Hsp70 expression, superoxide dismutase and cytochrome P450 activity in rat brainPhytother Res. (2002)
  9. Bhandari P, et al. Bacosterol glycoside, a new 13,14-seco-steroid glycoside from Bacopa monnieriChem Pharm Bull (Tokyo). (2006)
  10. Ghosh T, Maity TK, Singh J. Antihyperglycemic activity of bacosine, a triterpene from Bacopa monnieri, in alloxan-induced diabetic ratsPlanta Med. (2011)
  11. Bhandari P, et al. A rapid RP-HPTLC densitometry method for simultaneous determination of major flavonoids in important medicinal plantsJ Sep Sci. (2007)
  12. Bhandari P, et al. Silica-based monolithic column with evaporative light scattering detector for HPLC analysis of bacosides and apigenin in Bacopa monnieriJ Sep Sci. (2009)
  13. Deb DD, et al. In vitro safety evaluation and anticlastogenic effect of BacoMind on human lymphocytesBiomed Environ Sci. (2008)
  14. Murthy PB, et al. Estimation of twelve bacopa saponins in Bacopa monnieri extracts and formulations by high-performance liquid chromatographyChem Pharm Bull (Tokyo). (2006)
  15. Srivastava P, et al. Stability Studies of Crude Plant Material of Bacopa monnieri and Quantitative Determination of Bacopaside I and Bacoside A by HPLCPhytochem Anal. (2012)
  16. Determination of Saponin Glycosides in Bacopa monnieri by Reversed Phase High Performance Liquid Chromatography.
  17. Deepak M, et al. Quantitative determination of the major saponin mixture bacoside A in Bacopa monnieri by HPLCPhytochem Anal. (2005)
  18. Phrompittayarat W, et al. Stability studies of saponins in Bacopa monnieri dried ethanolic extractsPlanta Med. (2008)
  19. Sairam K, et al. Prophylactic and curative effects of Bacopa monniera in gastric ulcer modelsPhytomedicine. (2001)
  20. Goel RK, et al. In vitro evaluation of Bacopa monniera on anti-Helicobacter pylori activity and accumulation of prostaglandinsPhytomedicine. (2003)
  21. Dorababu M, et al. Effect of Bacopa monniera and Azadirachta indica on gastric ulceration and healing in experimental NIDDM ratsIndian J Exp Biol. (2004)
  22. Ramasamy S1, Kiew LV2, Chung LY3. Inhibition of human cytochrome P450 enzymes by Bacopa monnieri standardized extract and constituentsMolecules. (2014)
  23. Charles PD, et al. Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: implications in memory formationJ Ethnopharmacol. (2011)
  24. Rajan KE, et al. Attenuation of 1-(m-chlorophenyl)-biguanide induced hippocampus-dependent memory impairment by a standardised extract of Bacopa monniera (BESEB CDRI-08)Neurochem Res. (2011)
  25. Saraf MK, et al. Bacopa monniera Attenuates Scopolamine-Induced Impairment of Spatial Memory in MiceEvid Based Complement Alternat Med. (2011)
  26. Vollala VR, Upadhya S, Nayak S. Enhanced dendritic arborization of hippocampal CA3 neurons by Bacopa monniera extract treatment in adult ratsRom J Morphol Embryol. (2011)
  27. Vollala VR, Upadhya S, Nayak S. Enhancement of basolateral amygdaloid neuronal dendritic arborization following Bacopa monniera extract treatment in adult ratsClinics (Sao Paulo). (2011)
  28. Vollala VR, Upadhya S, Nayak S. Enhanced dendritic arborization of amygdala neurons during growth spurt periods in rats orally intubated with Bacopa monniera extractAnat Sci Int. (2011)
  29. Roodenrys S, et al. Chronic effects of Brahmi (Bacopa monnieri) on human memoryNeuropsychopharmacology. (2002)
  30. Stough C, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjectsPsychopharmacology (Berl). (2001)
  31. Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trialJ Altern Complement Med. (2010)
  32. Stough C, et al. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trialPhytother Res. (2008)
  33. Raghav S, et al. Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairmentIndian J Psychiatry. (2006)
  34. Katz M, et al. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trialJ Atten Disord. (2010)
  35. Nathan PJ, et al. Effects of a combined extract of Ginkgo biloba and Bacopa monniera on cognitive function in healthy humansHum Psychopharmacol. (2004)
  36. Maher BF, et al. The acute effects of combined administration of Ginkgo biloba and Bacopa monniera on cognitive function in humansHum Psychopharmacol. (2002)
  37. Nathan PJ, et al. The acute effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy normal subjectsHum Psychopharmacol. (2001)
  38. Pase MP, et al. The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trialsJ Altern Complement Med. (2012)
  39. Neale C, et al. Cognitive effects of two nutraceuticals Ginseng and Bacopa benchmarked against modafinil: a review and comparison of effect sizesBr J Clin Pharmacol. (2012)
  40. Kishore K, Singh M. Effect of bacosides, alcoholic extract of Bacopa monniera Linn. (brahmi), on experimental amnesia in miceIndian J Exp Biol. (2005)
  41. Prabhakar S, et al. Bacopa monniera exerts antiamnesic effect on diazepam-induced anterograde amnesia in micePsychopharmacology (Berl). (2008)
  42. Saraf MK, Prabhakar S, Anand A. Bacopa monniera alleviates N(omega)-nitro-L-arginine arginine-induced but not MK-801-induced amnesia: a mouse Morris watermaze studyNeuroscience. (2009)
  43. Sathyanarayanan V, et al. Brahmi for the better? New findings challenging cognition and anti-anxiety effects of Brahmi (Bacopa monniera) in healthy adultsPsychopharmacology (Berl). (2013)
  44. Jadiya P, et al. Anti-Parkinsonian effects of Bacopa monnieri: insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson’s diseaseBiochem Biophys Res Commun. (2011)
  45. Shinomol GK, et al. Bacopa monnieri extract offsets rotenone-induced cytotoxicity in dopaminergic cells and oxidative impairments in mice brainCell Mol Neurobiol. (2012)
  46. Sheikh N, et al. Effect of Bacopa monniera on stress induced changes in plasma corticosterone and brain monoamines in ratsJ Ethnopharmacol. (2007)
  47. Hosamani R, Muralidhara. Neuroprotective efficacy of Bacopa monnieri against rotenone induced oxidative stress and neurotoxicity in Drosophila melanogasterNeurotoxicology. (2009)
  48. Rauf K, Subhan F, Sewell RD. A Bacoside Containing Bacopa monnieri Extract Reduces Both Morphine Hyperactivity Plus the Elevated Striatal Dopamine and Serotonin TurnoverPhytother Res. (2012)
  49. Das A, et al. A comparative study in rodents of standardized extracts of Bacopa monniera and Ginkgo biloba: anticholinesterase and cognitive enhancing activitiesPharmacol Biochem Behav. (2002)
  50. Uabundit N, et al. Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer’s disease modelJ Ethnopharmacol. (2010)
  51. Limpeanchob N, et al. Neuroprotective effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical cultureJ Ethnopharmacol. (2008)
  52. Piyabhan P, Wetchateng T. Cognitive enhancement effects of Bacopa monnieri (Brahmi) on novel object recognition and VGLUT1 density in the prefrontal cortex, striatum, and hippocampus of sub-chronic phencyclidine rat model of schizophreniaJ Med Assoc Thai. (2013)
  53. Paulose CS, et al. Neuroprotective role of Bacopa monnieri extract in epilepsy and effect of glucose supplementation during hypoxia: glutamate receptor gene expressionNeurochem Res. (2008)
  54. Khan R, Krishnakumar A, Paulose CS. Decreased glutamate receptor binding and NMDA R1 gene expression in hippocampus of pilocarpine-induced epileptic rats: neuroprotective role of Bacopa monnieri extractEpilepsy Behav. (2008)
  55. Mathew J, et al. Bacopa monnieri and Bacoside-A for ameliorating epilepsy associated behavioral deficitsFitoterapia. (2010)
  56. Shanmugasundaram ER, Akbar GK, Shanmugasundaram KR. Brahmighritham, an Ayurvedic herbal formula for the control of epilepsyJ Ethnopharmacol. (1991)
  57. Mathew J, et al. Behavioral deficit and decreased GABA receptor functional regulation in the hippocampus of epileptic rats: effect of Bacopa monnieriNeurochem Res. (2011)
  58. Mathew J, et al. Decreased GABA receptor in the striatum and spatial recognition memory deficit in epileptic rats: effect of Bacopa monnieri and bacoside-AJ Ethnopharmacol. (2010)
  59. Mathew J, et al. Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-AJ Biomed Sci. (2012)
  60. Mathew J, et al. Increased excitability and metabolism in pilocarpine induced epileptic rats: effect of Bacopa monnieriFitoterapia. (2010)
  61. Prince HK, et al. Down-regulation of AMPA receptor subunit GluR2 in amygdaloid kindlingJ Neurochem. (1995)
  62. Kral T, et al. Down-regulation of mGluR8 in pilocarpine epileptic ratsSynapse. (2003)
  63. Krishnakumar A, et al. Down-regulation of cerebellar 5-HT(2C) receptors in pilocarpine-induced epilepsy in rats: therapeutic role of Bacopa monnieri extractJ Neurol Sci. (2009)
  64. Krishnakumar A, Nandhu MS, Paulose CS. Upregulation of 5-HT2C receptors in hippocampus of pilocarpine-induced epileptic rats: antagonism by Bacopa monnieriEpilepsy Behav. (2009)
  65. Rai D, et al. Adaptogenic effect of Bacopa monniera (Brahmi)Pharmacol Biochem Behav. (2003)
  66. Chatterjee M, Verma P, Palit G. Comparative evaluation of Bacopa monniera and Panax quniquefolium in experimental anxiety and depressive models in miceIndian J Exp Biol. (2010)
  67. Downey LA, et al. An Acute, Double-Blind, Placebo-Controlled Crossover Study of 320 mg and 640 mg Doses of a Special Extract of Bacopa monnieri (CDRI 08) on Sustained Cognitive PerformancePhytother Res. (2012)
  68. Bhattacharya SK, et al. Antioxidant activity of Bacopa monniera in rat frontal cortex, striatum and hippocampusPhytother Res. (2000)
  69. Tripathi S, et al. Protective potential of Bacopa monniera (Brahmi) extract on aluminum induced cerebellar toxicity and associated neuromuscular status in aged ratsCell Mol Biol (Noisy-le-grand). (2011)
  70. Sumathi T, et al. Protective Effect of Bacopa monniera on Methyl Mercury-Induced Oxidative Stress in Cerebellum of RatsCell Mol Neurobiol. (2012)
  71. Tripathi YB, et al. Bacopa monniera Linn. as an antioxidant: mechanism of actionIndian J Exp Biol. (1996)
  72. Jyoti A, Sethi P, Sharma D. Bacopa monniera prevents from aluminium neurotoxicity in the cerebral cortex of rat brainJ Ethnopharmacol. (2007)
  73. Jyoti A, Sharma D. Neuroprotective role of Bacopa monniera extract against aluminium-induced oxidative stress in the hippocampus of rat brainNeurotoxicology. (2006)
  74. Lenka M, Panda KK, Panda BB. Monitoring and assessment of mercury pollution in the vicinity of a chloralkali plant. IV. Bioconcentration of mercury in in situ aquatic and terrestrial plants at Ganjam, IndiaArch Environ Contam Toxicol. (1992)
  75. Rastogi M, et al. Amelioration of age associated neuroinflammation on long term bacosides treatmentNeurochem Res. (2012)
  76. Inhibition of pro-inflammatory mediators: role of Bacopa monniera (L.) Wettst.
  77. Dhanasekaran M, et al. Neuroprotective mechanisms of ayurvedic antidementia botanical Bacopa monnieraPhytother Res. (2007)
  78. Zhou Y, et al. Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice modelsJ Nat Prod. (2007)
  79. Sairam K, et al. Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in ratsPhytomedicine. (2002)
  80. Kamkaew N, et al. Bacopa monnieri Increases Cerebral Blood Flow in Rat Independent of Blood PressurePhytother Res. (2012)
  81. Kamkaew N, et al. Bacopa monnieri and its constituents is hypotensive in anaesthetized rats and vasodilator in various artery typesJ Ethnopharmacol. (2011)
  82. Bhaskar M, Jagtap AG. Exploring the possible mechanisms of action behind the antinociceptive activity of Bacopa monnieraInt J Ayurveda Res. (2011)
  83. Efficacy of Bacopa Monnieri in Revitalizing Intellectual Functions in Children.
  84. Vollala VR, Upadhya S, Nayak S. Learning and memory-enhancing effect of Bacopa monniera in neonatal ratsBratisl Lek Listy. (2011)
  85. Singh A, Singh SK. Evaluation of antifertility potential of Brahmi in male mouseContraception. (2009)
  86. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice.
  87. Mishra RK, Singh SK. Reversible antifertility effect of aqueous rhizome extract of Curcuma longa L. in male laboratory miceContraception. (2009)
  88. Velmurugan K, et al. Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement ProtandimFree Radic Biol Med. (2009)
  89. Ramanathan M, Balaji B, Justin A. Behavioural and neurochemical evaluation of Perment an herbal formulation in chronic unpredictable mild stress induced depressive modelIndian J Exp Biol. (2011)
  90. Kapoor R, Srivastava S, Kakkar P. Bacopa monnieri modulates antioxidant responses in brain and kidney of diabetic ratsEnviron Toxicol Pharmacol. (2009)
  91. Calabrese C, et al. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trialJ Altern Complement Med. (2008)