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Literatúra

  1. The effects of 4 weeks of an arginine-based supplement on the gas exchange threshold and peak oxygen uptake.
  2. Effects of arginine-based supplements on the physical working capacity at the fatigue threshold.
  3. Effect of a novel dietary supplement on skin aging in post-menopausal women.
  4. Clinical, biometric and ultrasound assessment of the effects of daily use of a nutraceutical composed of lycopene, acerola extract, grape seed extract and Biomarine Complex in photoaged human skin.
  5. Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study.
  6. Supplementation with grape seed polyphenols results in increased urinary excretion of 3-hydroxyphenylpropionic Acid, an important metabolite of proanthocyanidins in humans.
  7. Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract.
  8. Rzeppa S, et al. Analysis of Flavan-3-ols and procyanidins in food samples by reversed phase high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (RP-HPLC-ESI-MS/MS). J Agric Food Chem. (2011)
  9. Concentrations of Proanthocyanidins in Common Foods and Estimations of Normal Consumption.
  10. Rohdewald P. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther. (2002)
  11. Kijima I, et al. Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res. (2006)
  12. Yilmazer-Musa M, et al. Grape Seed and Tea Extracts and Catechin 3-Gallates Are Potent Inhibitors of α-Amylase and α-Glucosidase Activity. J Agric Food Chem. (2012)
  13. Overman A, et al. Polyphenol-rich grape powder extract (GPE) attenuates inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media. Int J Obes (Lond). (2010)
  14. Tsang C, et al. The absorption, metabolism and excretion of flavan-3-ols and procyanidins following the ingestion of a grape seed extract by rats. Br J Nutr. (2005)
  15. Shoji T, et al. Apple procyanidin oligomers absorption in rats after oral administration: analysis of procyanidins in plasma using the porter method and high-performance liquid chromatography/tandem mass spectrometry. J Agric Food Chem. (2006)
  16. Appeldoorn MM, et al. Procyanidin dimers A1, A2, and B2 are absorbed without conjugation or methylation from the small intestine of rats. J Nutr. (2009)
  17. Baba S, et al. Absorption and urinary excretion of procyanidin B2 {epicatechin-(4beta-8)-epicatechin} in rats. Free Radic Biol Med. (2002)
  18. Procyanidins are not bioavailable in rats fed a single meal containing a grapeseed extract or the procyanidin dimer B3.
  19. Rzeppa S, et al. Urinary excretion and metabolism of procyanidins in pigs. Mol Nutr Food Res. (2012)
  20. Serra A, et al. Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models. Br J Nutr. (2010)
  21. Eng ET, et al. Suppression of estrogen biosynthesis by procyanidin dimers in red wine and grape seeds. Cancer Res. (2003)
  22. Numazawa M, et al. Synthesis of androst-5-en-7-ones and androsta-3,5-dien-7-ones and their related 7-deoxy analogs as conformational and catalytic probes for the active site of aromatase. J Med Chem. (1994)
  23. Binding Characteristics of Seven Inhibitors of Human Aromatase: A Site-directed Mutagenesis Study.
  24. Suppression of Estrogen Biosynthesis by Procyanidin Dimers in Red Wine and Grape Seeds.
  25. Athymic Nude Mice.
  26. Kim Y, et al. Antioxidant and cytoprotective effects of oligomeric and polymeric procyanidin fractions from defatted grape seed in PC12 cells. J Med Food. (2012)
  27. Ono K, et al. Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity. J Biol Chem. (2008)
  28. Wang J, et al. Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer’s disease. J Neurosci. (2008)
  29. Yanagida F, Srionnual S, Chen YS. Isolation and characteristics of lactic acid bacteria from koshu vineyards in Japan. Lett Appl Microbiol. (2008)
  30. Narita K, et al. Differential neuroprotective activity of two different grape seed extracts. PLoS One. (2011)
  31. Belviranlı M, et al. Effects of Grape Seed Polyphenols on Oxidative Damage in Liver Tissue of Acutely and Chronically Exercised Rats. Phytother Res. (2012)
  32. Belviranlı M, et al. Effects of grape seed extract supplementation on exercise-induced oxidative stress in rats. Br J Nutr. (2012)
  33. Feng Z, et al. Grape seed extract enhances eNOS expression and NO production through regulating calcium-mediated AKT phosphorylation in H2O2-treated endothelium. Cell Biol Int. (2010)
  34. Shao ZH, et al. Grape seed proanthocyanidins protect cardiomyocytes from ischemia and reperfusion injury via Akt-NOS signaling. J Cell Biochem. (2009)
  35. Edirisinghe I, Burton-Freeman B, Tissa Kappagoda C. Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract. Clin Sci (Lond). (2008)
  36. Shenoy SF, et al. Effects of grape seed extract consumption on platelet function in postmenopausal women. Thromb Res. (2007)
  37. Clifton PM. Effect of Grape Seed Extract and Quercetin on Cardiovascular and Endothelial Parameters in High-Risk Subjects. J Biomed Biotechnol. (2004)
  38. Sano A, Tokutake S, Seo A. Proanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sitting. J Sci Food Agric. (2012)
  39. Kar P, et al. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabet Med. (2009)
  40. Sivaprakasapillai B, et al. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. (2009)
  41. Sano A, et al. Beneficial effects of grape seed extract on malondialdehyde-modified LDL. J Nutr Sci Vitaminol (Tokyo). (2007)
  42. Feringa HH, et al. The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials. J Am Diet Assoc. (2011)
  43. Grape Polyphenols Do Not Affect Vascular Function in Healthy Men.
  44. Ward NC, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens. (2005)
  45. Schäfer A, Högger P. Oligomeric procyanidins of French maritime pine bark extract (Pycnogenol) effectively inhibit alpha-glucosidase. Diabetes Res Clin Pract. (2007)
  46. Castell-Auví A, et al. Grape seed procyanidins improve β-cell functionality under lipotoxic conditions due to their lipid-lowering effect. J Nutr Biochem. (2012)
  47. Montagut G, et al. Effects of a grapeseed procyanidin extract (GSPE) on insulin resistance. J Nutr Biochem. (2010)
  48. Charradi K, et al. Grape seed and skin extract prevents high-fat diet-induced brain lipotoxicity in rat. Neurochem Res. (2012)
  49. Cedó L, et al. Pancreatic islet proteome profile in Zucker fatty rats chronically treated with a grape seed procyanidin extract. Food Chem. (2012)
  50. Johnson JD. Proteomic identification of carboxypeptidase E connects lipid-induced beta-cell apoptosis and dysfunction in type 2 diabetes. Cell Cycle. (2009)
  51. Parcellier A, et al. Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways. Biochem Biophys Res Commun. (2003)
  52. Bando Y, et al. GRP94 reduces cell death in SH-SY5Y cells perturbated calcium homeostasis. Apoptosis. (2004)
  53. Montagut G, et al. Oligomers of grape-seed procyanidin extract activate the insulin receptor and key targets of the insulin signaling pathway differently from insulin. J Nutr Biochem. (2010)
  54. Pinent M, et al. Metabolic fate of glucose on 3T3-L1 adipocytes treated with grape seed-derived procyanidin extract (GSPE). Comparison with the effects of insulin. J Agric Food Chem. (2005)
  55. Meeprom A, et al. Grape seed extract supplementation prevents high-fructose diet-induced insulin resistance in rats by improving insulin and adiponectin signalling pathways. Br J Nutr. (2011)
  56. Effects of dietary grape seed tannins on rat cecal fermentation and colonic bacterial enzymes.
  57. Vogels N, Nijs IM, Westerterp-Plantenga MS. The effect of grape-seed extract on 24 h energy intake in humans. Eur J Clin Nutr. (2004)
  58. Moreno DA, et al. Inhibitory effects of grape seed extract on lipases. Nutrition. (2003)
  59. Caimari A, et al. Low doses of grape seed procyanidins reduce adiposity and improve the plasma lipid profile in hamsters. Int J Obes (Lond). (2012)
  60. Pinent M, et al. Grape-seed derived procyanidins interfere with adipogenesis of 3T3-L1 cells at the onset of differentiation. Int J Obes (Lond). (2005)
  61. Chacón MR, et al. Grape-seed procyanidins modulate inflammation on human differentiated adipocytes in vitro. Cytokine. (2009)
  62. Pinent M, et al. Grape seed-derived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines. Endocrinology. (2004)
  63. Charradi K, et al. Grape seed extract alleviates high-fat diet-induced obesity and heart dysfunction by preventing cardiac siderosis. Cardiovasc Toxicol. (2011)
  64. Intake and bioaccessibility of total polyphenols in a whole diet.
  65. Serrano J, et al. Tannins: current knowledge of food sources, intake, bioavailability and biological effects. Mol Nutr Food Res. (2009)
  66. Castrillejo VM, et al. Antioxidant effects of a grapeseed procyanidin extract and oleoyl-estrone in obese Zucker rats. Nutrition. (2011)
  67. Terra X, et al. Grape-seed procyanidins act as antiinflammatory agents in endotoxin-stimulated RAW 264.7 macrophages by inhibiting NFkB signaling pathway. J Agric Food Chem. (2007)
  68. Houde V, Grenier D, Chandad F. Protective effects of grape seed proanthocyanidins against oxidative stress induced by lipopolysaccharides of periodontopathogens. J Periodontol. (2006)
  69. Wang YH, et al. Proanthocyanidins from grape seeds modulates the nuclear factor-kappa B signal transduction pathways in rats with TNBS-induced recurrent ulcerative colitis. Int Immunopharmacol. (2011)
  70. Wang YH, et al. Effects of proanthocyanidins from grape seed on treatment of recurrent ulcerative colitis in rats. Can J Physiol Pharmacol. (2010)
  71. Li XL, et al. Therapeutic effect and mechanism of proanthocyanidins from grape seeds in rats with TNBS-induced ulcerative colitis. Can J Physiol Pharmacol. (2008)
  72. Velmurugan B, et al. Dietary feeding of grape seed extract prevents intestinal tumorigenesis in APCmin/+ mice. Neoplasia. (2010)
  73. Romier-Crouzet B, et al. Inhibition of inflammatory mediators by polyphenolic plant extracts in human intestinal Caco-2 cells. Food Chem Toxicol. (2009)
  74. Tang Q, et al. Grape-seed proanthocyanidins ameliorate contact hypersensitivity induced by 2,4-dinitrofluorobenzene (DNFB) and inhibit T cell proliferation in vitro. Toxicol Lett. (2012)
  75. Morillas-Ruiz JM, et al. Effects of polyphenolic antioxidants on exercise-induced oxidative stress. Clin Nutr. (2006)
  76. Nuttall SL, et al. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther. (1998)
  77. De Groote D, et al. Effect of the intake of resveratrol, resveratrol phosphate, and catechin-rich grape seed extract on markers of oxidative stress and gene expression in adult obese subjects. Ann Nutr Metab. (2012)
  78. Wahner-Roedler DL1, et al. The effect of grape seed extract on estrogen levels of postmenopausal women: a pilot study. J Diet Suppl. (2014)
  79. El-Ashmawy IM, Saleh A, Salama OM. Effects of marjoram volatile oil and grape seed extract on ethanol toxicity in male rats. Basic Clin Pharmacol Toxicol. (2007)
  80. Kampa M, et al. Novel oligomeric proanthocyanidin derivatives interact with membrane androgen sites and induce regression of hormone-independent prostate cancer. J Pharmacol Exp Ther. (2011)
  81. Nifli AP, et al. Monomeric and oligomeric flavanols are agonists of membrane androgen receptors. Exp Cell Res. (2005)
  82. Cuevas VM, et al. Effects of grape seed extract, vitamin C, and vitamin e on ethanol- and aspirin-induced ulcers. Adv Pharmacol Sci. (2011)
  83. Antiulcer Activity of Grape Seed Extract and Procyanidins.
  84. Ye X, et al. The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells. Mol Cell Biochem. (1999)
  85. Ramchandani AG, Karibasappa GS, Pakhale SS. Antitumor-promoting effects of polyphenolic extracts from seedless and seeded Indian grapes. J Environ Pathol Toxicol Oncol. (2008)
  86. Wei R, et al. Grape seed proanthocyanidin extract reduces renal ischemia/reperfusion injuries in rats. Am J Med Sci. (2012)
  87. Ulusoy S, et al. Anti-apoptotic and anti-oxidant effects of grape seed proanthocyanidin extract in preventing cyclosporine A-induced nephropathy. Nephrology (Carlton). (2012)
  88. Ulusoy S, et al. The effect of grape seed proanthocyanidin extract in preventing amikacin-induced nephropathy. Ren Fail. (2012)
  89. Bagchi D, et al. Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice. Gen Pharmacol. (1998)
  90. Mohanasundari M, Sabesan M, Sethupathy S. Renoprotective effect of grape seeds extract in ethylene glycol induced nephrotoxic mice. Indian J Exp Biol. (2005)
  91. Saad AA, Youssef MI, El-Shennawy LK. Cisplatin induced damage in kidney genomic DNA and nephrotoxicity in male rats: the protective effect of grape seed proanthocyanidin extract. Food Chem Toxicol. (2009)
  92. Salem NA, Salem EA. Renoprotective effect of grape seed extract against oxidative stress induced by gentamicin and hypercholesterolemia in rats. Ren Fail. (2011)
  93. Mansouri E, et al. Effects of grape seed proanthocyanidin extract on oxidative stress induced by diabetes in rat kidney. Iran Biomed J. (2011)
  94. Li X, et al. Grape seed proanthocyanidins ameliorate diabetic nephropathy via modulation of levels of AGE, RAGE and CTGF. Nephron Exp Nephrol. (2009)
  95. Lu M, et al. Protective effects of grape seed proanthocyanidin extracts on cerebral cortex of streptozotocin-induced diabetic rats through modulating AGEs/RAGE/NF-kappaB pathway. J Nutr Sci Vitaminol (Tokyo). (2010)
  96. Cheng M, et al. Cardioprotective effects of grape seed proanthocyanidins extracts in streptozocin induced diabetic rats. J Cardiovasc Pharmacol. (2007)
  97. Dinicola S, et al. Antiproliferative and Apoptotic Effects Triggered by Grape Seed Extract (GSE) versus Epigallocatechin and Procyanidins on Colon Cancer Cell Lines. Int J Mol Sci. (2012)
  98. Radhakrishnan S, et al. Resveratrol potentiates grape seed extract induced human colon cancer cell apoptosis. Front Biosci (Elite Ed). (2011)
  99. Kim H, et al. Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependent. J Nutr. (2004)
  100. Brooker S, et al. Double-blind, placebo-controlled, randomised phase II trial of IH636 grape seed proanthocyanidin extract (GSPE) in patients with radiation-induced breast induration. Radiother Oncol. (2006)
  101. Shrotriya S, et al. Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells. Carcinogenesis. (2012)
  102. Yamakoshi J, et al. Oral intake of proanthocyanidin-rich extract from grape seeds improves chloasma. Phytother Res. (2004)
  103. Yamakoshi J, et al. Safety evaluation of proanthocyanidin-rich extract from grape seeds. Food Chem Toxicol. (2002)
  104. Vigna GB, et al. Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers. Metabolism. (2003)