Kolagén – typ II

Pôsobí na: zdravie svalov a kĺbov, spomalenie starnutia, zachovanie celkového zdravia

Kolagén – typ II je súčasťou kĺbovej chrupavky. Jeho orálny príjem znižuje autoimunitnú reakciu tela voči vlastnému kolagénu. Tým sa zmierňujú zápaly pri osteoartritíde a reume, čo je prospešné pre zdravie kĺbov.

Užívanie

Kolagén sa užíva v dvoch odlišných formách. Buď vo forme hydrolyzovaného kolagénu alebo v nedenaturovanej forme. Dávkovanie je pri týchto formách odlišné. Hydrolyzovaná forma sa užíva v dávke 10 g denne za účelom zlepšenia stavu pokožky a miernych účinkov na kĺby. Môže sa užívať spolu s jedlom. Nemal by sa užívať vo vyšších dávkach za účelom rastu svalovej hmoty, pretože má horšiu účinnosť ako iné proteíny a nevhodný profil aminokyselín.
Nedenaturovaný kolagén sa užíva 1x denne v dávke 40 mg ako liečba osteoartritídy a reumy s autoimunitnou príčinou. Hoci nie je potrebné užívať túto formu v nejakom presnom čase, je ideálne užiť dávku pred raňajkami na prázdny žalúdok.

Medicínske upozornenie!

Literatúra

  1. Adam M1, et al. Postmenopausal osteoporosis. Treatment with calcitonin and a diet rich in collagen proteins. Cas Lek Cesk. (1996)
  2. Schwartz SR1, Park J. Ingestion of BioCell Collagen(®), a novel hydrolyzed chicken sternal cartilage extract; enhanced blood microcirculation and reduced facial aging signs. Clin Interv Aging. (2012)
  3. Nomura Y1, et al. Increase in bone mineral density through oral administration of shark gelatin to ovariectomized rats. Nutrition. (2005)
  4. Oesser S1, et al. Oral administration of (14)C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL). J Nutr. (1999)
  5. Asghar A, Henrickson RL. Chemical, biochemical, functional, and nutritional characteristics of collagen in food systems. Adv Food Res. (1982)
  6. The amino acid composition of mammalian collagen and gelatin.
  7. NEUMAN RE. The amino acid composition of gelatins, collagens and elastins from different sources. Arch Biochem. (1949)
  8. Wu J1, et al. Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats. J Bone Miner Metab. (2004)
  9. Zhu P1, et al. Oral administration of type-II collagen peptide 250-270 suppresses specific cellular and humoral immune response in collagen-induced arthritis. Clin Immunol. (2007)
  10. Kakoi C1, et al. Collagen peptides enhance hippocampal neurogenesis and reduce anxiety related behavior in mice. Biomed Res. (2012)
  11. Glyprolines in regulatory tripeptides.
  12. Oral Administration of Shark Type II Collagen Suppresses Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis in Rats.
  13. Di Cesare Mannelli L, et al. Low dose native type II collagen prevents pain in a rat osteoarthritis model. BMC Musculoskelet Disord. (2013)
  14. Lugo JP, et al. Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. J Int Soc Sports Nutr. (2013)
  15. Crowley DC1, et al. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. (2009)
  16. Wright NT, Humphrey JD. Denaturation of collagen via heating: an irreversible rate process. Annu Rev Biomed Eng. (2002)
  17. Marone PA1, et al. Safety and toxicological evaluation of undenatured type II collagen. Toxicol Mech Methods. (2010)
  18. Moskowitz RW. Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum. (2000)
  19. Khiari Z1, Ndagijimana M1, Betti M2. Low molecular weight bioactive peptides derived from the enzymatic hydrolysis of collagen after isoelectric solubilization/precipitation process of turkey by-products. Poult Sci. (2014)
  20. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort.
  21. Eyre D. Collagen of articular cartilage. Arthritis Res. (2002)
  22. Eyre DR, et al. Biosynthesis of collagen and other matrix proteins by articular cartilage in experimental osteoarthrosis. Biochem J. (1980)
  23. Bagchi D1, et al. Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. Int J Clin Pharmacol Res. (2002)
  24. Tong T1, et al. Chicken type II collagen induced immune balance of main subtype of helper T cells in mesenteric lymph node lymphocytes in rats with collagen-induced arthritis. Inflamm Res. (2010)
  25. McDole JR1, et al. Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature. (2012)
  26. Min SY1, et al. Antigen-induced, tolerogenic CD11c+,CD11b+ dendritic cells are abundant in Peyer’s patches during the induction of oral tolerance to type II collagen and suppress experimental collagen-induced arthritis. Arthritis Rheum. (2006)
  27. Park MJ1, et al. Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer’s patches in an orally tolerized, collagen-induced arthritis mouse model. Arthritis Res Ther. (2008)
  28. Baker AM1, et al. Central penetration and stability of N-terminal tripeptide of insulin-like growth factor-I, glycine-proline-glutamate in adult rat. Neuropeptides. (2005)
  29. Skaper SD. Peptide mimetics of neurotrophins and their receptors. Curr Pharm Des. (2011)
  30. Takeuchi Y1, Nakayama K, Matsumoto T. Differentiation and cell surface expression of transforming growth factor-beta receptors are regulated by interaction with matrix collagen in murine osteoblastic cells. J Biol Chem. (1996)
  31. Takeuchi Y1, et al. Differentiation and transforming growth factor-beta receptor down-regulation by collagen-alpha2beta1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells. J Biol Chem. (1997)
  32. Gimsa U1, et al. Type II collagen serology: a guide to clinical responsiveness to oral tolerance. Rheumatol Int. (1997)
  33. Guzman RE1, et al. Mono-iodoacetate-induced histologic changes in subchondral bone and articular cartilage of rat femorotibial joints: an animal model of osteoarthritis. Toxicol Pathol. (2003)
  34. De Ceuninck F1, Sabatini M, Pastoureau P. Recent progress toward biomarker identification in osteoarthritis. Drug Discov Today. (2011)
  35. De Ceuninck F1, et al. Urinary collagen type II C-telopeptide fragments are sensitive markers of matrix metalloproteinase-dependent cartilage degradation in rat adjuvant-induced arthritis. J Rheumatol. (2003)
  36. van Amelsfort JM1, et al. CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthritis Rheum. (2004)
  37. Möttönen M1, et al. CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis. Clin Exp Immunol. (2005)
  38. de Kleer IM1, et al. CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J Immunol. (2004)
  39. Ruprecht CR1, et al. Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia. J Exp Med. (2005)
  40. Wehrens EJ1, et al. Treating arthritis by immunomodulation: is there a role for regulatory T cells. Rheumatology (Oxford). (2010)
  41. de Jager W1, et al. Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study. Ann Rheum Dis. (2007)
  42. Harada S1, et al. Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum. (1999)
  43. Collagen-induced arthritis.
  44. Min SY1, et al. Induction of IL-10-producing CD4+CD25+ T cells in animal model of collagen-induced arthritis by oral administration of type II collagen. Arthritis Res Ther. (2004)
  45. Thomé R1, et al. Oral tolerance and OVA-induced tolerogenic dendritic cells reduce the severity of collagen/ovalbumin-induced arthritis in mice. Cell Immunol. (2012)
  46. Yoshinari O1, et al. Water-soluble undenatured type II collagen ameliorates collagen-induced arthritis in mice. J Med Food. (2013)
  47. Heo YJ1, et al. IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients. Immunol Lett. (2010)
  48. Trentham DE1, et al. Effects of oral administration of type II collagen on rheumatoid arthritis. Science. (1993)
  49. Barnett ML1, et al. Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum. (1998)
  50. Thorbecke GJ1, et al. Modulation by cytokines of induction of oral tolerance to type II collagen. Arthritis Rheum. (1999)
  51. Moses HL1, et al. TGF beta regulation of cell proliferation. Princess Takamatsu Symp. (1994)
  52. Nakae S1, et al. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol. (2003)
  53. Henningsson L1, et al. Disease-dependent local IL-10 production ameliorates collagen induced arthritis in mice. PLoS One. (2012)
  54. Yang M1, et al. IL-10-producing regulatory B10 cells ameliorate collagen-induced arthritis via suppressing Th17 cell generation. Am J Pathol. (2012)
  55. Iizuka M1, et al. Suppression of collagen-induced arthritis by oral administration of transgenic rice seeds expressing altered peptide ligands of type II collagen. Plant Biotechnol J. (2014)
  56. Belz GT1, Heath WR, Carbone FR. The role of dendritic cell subsets in selection between tolerance and immunity. Immunol Cell Biol. (2002)
  57. Maldonado RA1, von Andrian UH. How tolerogenic dendritic cells induce regulatory T cells. Adv Immunol. (2010)
  58. Fallarino F1, et al. Modulation of tryptophan catabolism by regulatory T cells. Nat Immunol. (2003)
  59. The extracellular matrix at a glance.
  60. Oishi Y1, et al. Molecular basis of the alteration in skin collagen metabolism in response to in vivo dexamethasone treatment: effects on the synthesis of collagen type I and III, collagenase, and tissue inhibitors of metalloproteinases. Br J Dermatol. (2002)
  61. Quan T1, et al. Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type II receptor/Smad signaling. Am J Pathol. (2004)
  62. Fisher GJ1, et al. c-Jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid. J Clin Invest. (2000)
  63. Fisher GJ1, et al. Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature. (1996)
  64. Iwai K1, et al. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. J Agric Food Chem. (2005)
  65. Shigemura Y1, et al. Effect of Prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin. J Agric Food Chem. (2009)
  66. Ohara H1, et al. Effects of Pro-Hyp, a collagen hydrolysate-derived peptide, on hyaluronic acid synthesis using in vitro cultured synovium cells and oral ingestion of collagen hydrolysates in a guinea pig model of osteoarthritis. Biosci Biotechnol Biochem. (2010)
  67. Ohara H1, et al. Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. J Dermatol. (2010)
  68. Kawada C, et al. Ingested hyaluronan moisturizes dry skin. Nutr J. (2014)
  69. Yoshinari O1, et al. Safety and toxicological evaluation of a novel, water-soluble undenatured type II collagen. Toxicol Mech Methods. (2013)
  70. Barnett ML, Combitchi D, Trentham DE. A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis. Arthritis Rheum. (1996)