Valín

Pôsobí na: zachovanie celkového zdravia

Valín je jednou z trojvetvových aminokyselín. Iba zriedkavo sa testuje izolovane. Pravdepodobne je pre telo najmenej dôležitou aminokyselinou s rozvetveným reťazcom (BCAA) a nezdá sa, že by s ním bol spojený nejaký jedinečný benefit.

Užívanie

V súčasnosti nemáme dosť údajov na odporučenie nejakej optimálnej dávky. Nemáme ani informácie o tom, na aký účel by sa mal valín užívať.

Medicínske upozornenie!

Literatúra

  1. Nutraceutical Effects of Branched-Chain Amino Acids on Skeletal Muscle.
  2. FONES WS, SOBER HA, WHITE J. The conversion of D-valine to glycogen in the ratArch Biochem Biophys. (1951)
  3. FONES WS, WAALKES TP, WHITE J. The conversion of L-valine to glucose and glycogen in the ratArch Biochem Biophys. (1951)
  4. FONES WS, WHITE J. The conversion of L-valine to glycogen and carbon dioxide in rats receiving p-dimethylaminoazobenzeneJ Natl Cancer Inst. (1951)
  5. Birkhahn RH, Robertson LA, Okuno M. Isoleucine and valine oxidation following skeletal trauma in ratsJ Trauma. (1986)
  6. Komatsu H, et al. Effect of valine-depleted total parenteral nutrition on fatty liver development in tumor-bearing ratsNutrition. (1998)
  7. Nishihira T, et al. Anti-cancer therapy with valine-depleted amino acid imbalance solutionTohoku J Exp Med. (1988)
  8. Gloaguen M, et al. Providing a diet deficient in valine but with excess leucine results in a rapid decrease in feed intake and modifies the postprandial plasma amino acid and α-keto acid concentrations in pigsJ Anim Sci. (2012)
  9. Nishihira T, et al. Prevention of fatty liver and maintenance of systemic valine depletion using a newly developed dual infusion systemJPEN J Parenter Enteral Nutr. (1995)
  10. Armon C. Sports and trauma in amyotrophic lateral sclerosis revisitedJ Neurol Sci. (2007)
  11. Chiò A, et al. Severely increased risk of amyotrophic lateral sclerosis among Italian professional football playersBrain. (2005)
  12. Belli S, Vanacore N. Proportionate mortality of Italian soccer players: is amyotrophic lateral sclerosis an occupational diseaseEur J Epidemiol. (2005)
  13. Valenti M, et al. Amyotrophic lateral sclerosis and sports: a case-control studyEur J Neurol. (2005)
  14. Carunchio I, et al. Increased levels of p70S6 phosphorylation in the G93A mouse model of Amyotrophic Lateral Sclerosis and in valine-exposed cortical neurons in cultureExp Neurol. (2010)
  15. Vucic S, Kiernan MC. Cortical excitability testing distinguishes Kennedy’s disease from amyotrophic lateral sclerosisClin Neurophysiol. (2008)
  16. Zanette G, et al. Changes in motor cortex inhibition over time in patients with amyotrophic lateral sclerosisJ Neurol. (2002)
  17. Pieri M, et al. Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosisExp Neurol. (2009)
  18. van Zundert B, et al. Neonatal neuronal circuitry shows hyperexcitable disturbance in a mouse model of the adult-onset neurodegenerative disease amyotrophic lateral sclerosisJ Neurosci. (2008)
  19. Doi M, et al. Isoleucine, a potent plasma glucose-lowering amino acid, stimulates glucose uptake in C2C12 myotubesBiochem Biophys Res Commun. (2003)
  20. Fasching P, et al. Insulin production following intravenous glucose, arginine, and valine: different pattern in patients with impaired glucose tolerance and non-insulin-dependent diabetes mellitusMetabolism. (1994)
  21. Tokunaga C, Yoshino K, Yonezawa K. mTOR integrates amino acid- and energy-sensing pathwaysBiochem Biophys Res Commun. (2004)
  22. Fox HL, et al. Amino acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytesAm J Physiol. (1998)
  23. Lynch CJ, et al. Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytesJ Cell Biochem. (2000)
  24. Kakazu E, et al. Extracellular branched-chain amino acids, especially valine, regulate maturation and function of monocyte-derived dendritic cellsJ Immunol. (2007)
  25. Kakazu E, et al. Branched chain amino acids enhance the maturation and function of myeloid dendritic cells ex vivo in patients with advanced cirrhosisHepatology. (2009)
  26. MacDonald AJ, et al. Monocyte-derived dendritic cell function in chronic hepatitis C is impaired at physiological numbers of dendritic cellsClin Exp Immunol. (2007)
  27. Kawaguchi T, et al. Valine, a branched-chain amino Acid, reduced HCV viral load and led to eradication of HCV by interferon therapy in a decompensated cirrhotic patientCase Rep Gastroenterol. (2012)