Žihľava indická – Coleus forskohlii


  1. Pescosolido N, Librando A. Oral administration of an association of forskolin, rutin and vitamins B1 and B2 potentiates the hypotonising effects of pharmacological treatments in POAG patientsClin Ter. (2010)
  2. Oral Administration of Forskolin and Rutin Contributes to Reduce Intraocular Pressure and Improve PERG (Pattern Electroretinogram) Amplitude in Glaucomatous Patients.
  3. Vetrugno M1, et al. Oral administration of forskolin and rutin contributes to intraocular pressure control in primary open angle glaucoma patients under maximum tolerated medical therapyJ Ocul Pharmacol Ther. (2012)
  4. Agarwal KC, Parks RE Jr. Forskolin: a potential antimetastatic agentInt J Cancer. (1983)
  5. Pharmacognostic Evaluation of Coleus forskohlii.
  6. Rosmarinic acid, scutellarein 4′-methyl ether 7-O-glucuronide and (16S)-coleon E are the main compounds responsible for the antiacetylcholinesterase and antioxidant activity in herbal tea of Plectranthus barbatus (“falso boldo”).
  7. Wang YQ, et al. Studies on the chemical constituents of Coleus forskohliiZhong Yao Cai. (2009)
  8. Bodiwala HS, et al. Anti-HIV diterpenes from Coleus forskohliiNat Prod Commun. (2009)
  9. Yang QR, et al. Three new diterpenoids from Coleus forskohlii BriqJ Asian Nat Prod Res. (2006)
  10. Shen YH, Xu YL. Two new diterpenoids from Coleus forskohliiJ Asian Nat Prod Res. (2005)
  11. Alasbahi RH, Melzig MF. Forskolin and derivatives as tools for studying the role of cAMPPharmazie. (2012)
  12. Shan Y, et al. Diterpenes from Coleus forskohlii (WILLD.) BRIQ. (Labiatae)Chem Pharm Bull (Tokyo). (2008)
  13. Shan Y, et al. Two minor diterpene glycosides and an eudesman sesquiterpene from Coleus forskohliiChem Pharm Bull (Tokyo). (2007)
  14. Falé PL, et al. Function of Plectranthus barbatus herbal tea as neuronal acetylcholinesterase inhibitorFood Funct. (2011)
  15. Antiacetylcholinesterase and antioxidant activities of Plectranthus barbatus tea, after in vitro gastrointestinal metabolism.
  16. Xu LL, et al. Studies on the chemical constituents in root of Coleus forskohliiZhongguo Zhong Yao Za Zhi. (2005)
  17. Burns TW, et al. Comparative effects of forskolin and isoproterenol on the cyclic AMP content of human adipocytesLife Sci. (1987)
  18. Stability of Forskolin in Lipid Emulsions and Oil/Water Partition Coefficients.
  19. Iwatsubo K, Tsunematsu T, Ishikawa Y. Isoform-specific regulation of adenylyl cyclase: a potential target in future pharmacotherapyExpert Opin Ther Targets. (2003)
  20. Hanoune J, Defer N. Regulation and role of adenylyl cyclase isoformsAnnu Rev Pharmacol Toxicol. (2001)
  21. Litosch I, et al. Forskolin as an activator of cyclic AMP accumulation and lipolysis in rat adipocytesMol Pharmacol. (1982)
  22. Burns TW, et al. Alpha-2 adrenergic activation inhibits forskolin-stimulated adenylate cyclase activity and lipolysis in human adipocytesLife Sci. (1982)
  23. Costford SR, et al. Skeletal muscle NAMPT is induced by exercise in humansAm J Physiol Endocrinol Metab. (2010)
  24. Dubey MP, et al. Pharmacological studies on coleonol, a hypotensive diterpene from Coleus forskohliiJ Ethnopharmacol. (1981)
  25. Liu ZJ, et al. Intestinal Permeability of Forskolin by In Situ Single Pass Perfusion in RatsPlanta Med. (2012)
  26. Mante S1, Minneman KP. Caffeine inhibits forskolin-stimulated cyclic AMP accumulation in rat brainEur J Pharmacol. (1990)
  27. Mante S1, Minneman KP. Is adenosine involved in inhibition of forskolin-stimulated cyclic AMP accumulation by caffeine in rat brainMol Pharmacol. (1990)
  28. DeLapp NW1, Eckols K. Forskolin stimulation of cyclic AMP accumulation in rat brain cortex slices is markedly enhanced by endogenous adenosineJ Neurochem. (1992)
  29. Fredholm BB, Jonzon B, Lindström K. Effect of adenosine receptor agonists and other compounds on cyclic AMP accumulation in forskolin-treated hippocampal slicesNaunyn Schmiedebergs Arch Pharmacol. (1986)
  30. Alexander SP1, et al. A comparison of A2 adenosine receptor-induced cyclic AMP generation in cerebral cortex and relaxation of pre-contracted aortaBr J Pharmacol. (1994)
  31. Alexander SP1, et al. A1 adenosine receptor inhibition of cyclic AMP formation and radioligand binding in the guinea-pig cerebral cortexBr J Pharmacol. (1994)
  32. Henderson S, et al. Effects of coleus forskohlii supplementation on body composition and hematological profiles in mildly overweight womenJ Int Soc Sports Nutr. (2005)
  33. Godard MP, Johnson BA, Richmond SR. Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese menObes Res. (2005)
  34. Jagtap M, Chandola HM, Ravishankar B. Clinical efficacy of Coleus forskohlii (Willd.) Briq. (Makandi) in hypertension of geriatric populationAyu. (2011)
  35. Martin LF, et al. Alterations in adipocyte adenylate cyclase activity in morbidly obese and formerly morbidly obese humansSurgery. (1990)
  36. Activation of hormone-sensitive adenylate cyclase by forskolin.
  37. Filippa N, et al. Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinaseMol Cell Biol. (1999)
  38. Forskolin refractoriness.
  39. Duarte T, Menezes-Rodrigues FS, Godinho RO. Contribution of the extracellular cyclic AMP- adenosine pathway to dual coupling of β2-adrenoceptors to Gs and Gi proteins in mouse skeletal muscleJ Pharmacol Exp Ther. (2012)
  40. The effect of forskolin on the isometric contraction of the isolated hemidiaphragm of the rat.
  41. A novel role for β-adrenoceptor signalling in skeletal muscle growth, development and regeneration.
  42. Richmond SR, Touchberry CD, Gallagher PM. Forskolin attenuates the action of insulin on the Akt-mTOR pathway in human skeletal muscleAppl Physiol Nutr Metab. (2009)
  43. Niu W, et al. Insulin sensitivity and inhibition by forskolin, dipyridamole and pentobarbital of glucose transport in three L6 muscle cell linesSci China C Life Sci. (2007)
  44. Flores-Riveros JR, et al. Cyclic AMP-induced transcriptional repression of the insulin-responsive glucose transporter (GLUT4) gene: identification of a promoter region required for down-regulation of transcriptionBiochem Biophys Res Commun. (1993)
  45. Cooke DW, Lane MD. Transcription factor NF1 mediates repression of the GLUT4 promoter by cyclic-AMPBiochem Biophys Res Commun. (1999)
  46. Viñals F, et al. Cyclic adenosine 3′,5′-monophosphate regulates GLUT4 and GLUT1 glucose transporter expression and stimulates transcriptional activity of the GLUT1 promoter in muscle cellsEndocrinology. (1997)
  47. Sparks LM, et al. Remodeling lipid metabolism and improving insulin responsiveness in human primary myotubesPLoS One. (2011)
  48. Baar K. Involvement of PPAR gamma co-activator-1, nuclear respiratory factors 1 and 2, and PPAR alpha in the adaptive response to endurance exerciseProc Nutr Soc. (2004)
  49. Hood DA. Invited Review: contractile activity-induced mitochondrial biogenesis in skeletal muscleJ Appl Physiol. (2001)
  50. Baar K, et al. Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1FASEB J. (2002)
  51. Seldin MM, et al. Myonectin (CTRP15), a Novel Myokine That Links Skeletal Muscle to Systemic Lipid HomeostasisJ Biol Chem. (2012)
  52. Mulhall JP, et al. Intracavernosal forskolin: role in management of vasculogenic impotence resistant to standard 3-agent pharmacotherapyJ Urol. (1997)
  53. Pharmacology and inotropic potential of forskolin in the human heart.
  54. Caprioli J, Sears M. Forskolin lowers intraocular pressure in rabbits, monkeys, and manLancet. (1983)
  55. Burstein NL, Sears ML, Mead A. Aqueous flow in human eyes is reduced by forskolin, a potent adenylate cyclase activatorExp Eye Res. (1984)
  56. Head KA. Natural therapies for ocular disorders, part two: cataracts and glaucomaAltern Med Rev. (2001)
  57. Goldberg JL1, et al. Retinal ganglion cells do not extend axons by default: promotion by neurotrophic signaling and electrical activityNeuron. (2002)
  58. Meyer-Franke A1, et al. Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in cultureNeuron. (1995)
  59. Nakazawa T1, Tamai M, Mori N. Brain-derived neurotrophic factor prevents axotomized retinal ganglion cell death through MAPK and PI3K signaling pathwaysInvest Ophthalmol Vis Sci. (2002)
  60. Chen H1, Weber AJ. Brain-derived neurotrophic factor reduces TrkB protein and mRNA in the normal retina and following optic nerve crush in adult ratsBrain Res. (2004)
  61. Pernet V1, Di Polo A. Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivoBrain. (2006)
  62. Oral Administration of Forskolin and Rutin Contributes to Reduce Intraocular Pressure and Improve PERG (Pattern Electroretinogram) Amplitude in Glaucomatous Patients.
  63. Virgona N, et al. Coleus forskohlii extract induces hepatic cytochrome P450 enzymes in miceFood Chem Toxicol. (2012)
  64. Ding X, Staudinger JL. Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathwayJ Pharmacol Exp Ther. (2005)
  65. Valenti S, et al. In vitro acute and prolonged effects of melatonin on purified rat Leydig cell steroidogenesis and adenosine 3′,5′-monophosphate productionEndocrinology. (1995)
  66. Haider SG. Cell biology of Leydig cells in the testisInt Rev Cytol. (2004)
  67. Payne AH, Hales DB. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormonesEndocr Rev. (2004)
  68. Hsu CC, et al. Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesisFEBS Lett. (2003)
  69. Hermansen K. Forskolin, an activator of adenylate cyclase, stimulates pancreatic insulin, glucagon, and somatostatin release in the dog: studies in vitroEndocrinology. (1985)
  70. De Vries GW, et al. Effect of forskolin on beta-adrenergic hyporesponsiveness in skinSkin Pharmacol. (1988)
  71. Harper JF. Desensitization in rat parotid to beta-adrenergic agonists and counteracting effects of forskolin are conserved in membrane and detergent-solubilized adenylate cyclase catalyst activityJ Cyclic Nucleotide Protein Phosphor Res. (1986)
  72. Forskolin Potentiates Isoprenaline-Induced Glycerol Output and Local Blood Flow in Human Adipose Tissue in vivo.
  73. Lafontan M, Langin D. Lipolysis and lipid mobilization in human adipose tissueProg Lipid Res. (2009)
  74. Wellman GC, et al. Role of phospholamban in the modulation of arterial Ca(2+) sparks and Ca(2+)-activated K(+) channels by cAMPAm J Physiol Cell Physiol. (2001)
  75. Jeffries O, et al. cAMP/PKA-dependent increases in Ca Sparks, oscillations and SR Ca stores in retinal arteriolar myocytes after exposure to vasopressinInvest Ophthalmol Vis Sci. (2010)
  76. Jones SB, et al. Alpha 2-adrenergic receptor-mediated sensitization of forskolin-stimulated cyclic AMP productionProc Natl Acad Sci U S A. (1987)
  77. Jones SB, Bylund DB. Characterization and possible mechanisms of alpha 2-adrenergic receptor-mediated sensitization of forskolin-stimulated cyclic AMP production in HT29 cellsJ Biol Chem. (1988)
  78. [No authors listed. Coleus forskohlii. MonographAltern Med Rev. (2006)
  79. Krall JF, Jamgotchian N. Forskolin refractoriness. Exposure to the diterpene alters guanine nucleotide-dependent adenylate cyclase and calcium-uptake activity of cells cultured from the rat aortaBiochem J. (1987)
  80. Barovsky K, Pedone C, Brooker G. Forskolin-stimulated cyclic AMP accumulation mediates protein synthesis-dependent refractoriness in C6-2B rat glioma cellsJ Cyclic Nucleotide Protein Phosphor Res. (1983)
  81. Meyer BH, et al. The effects of forskolin eye drops on intra-ocular pressureS Afr Med J. (1987)
  82. Greenway FL, Bray GA. Regional fat loss from the thigh in obese women after adrenergic modulationClin Ther. (1987)
  83. González-Sánchez R, et al. Forskolin versus sodium cromoglycate for prevention of asthma attacks: a single-blinded clinical trialJ Int Med Res. (2006)
  84. Kaik G, Witte PU. Protective effect of forskolin in acetylcholine provocation in healthy probands. Comparison of 2 doses with fenoterol and placeboWien Med Wochenschr. (1986)
  85. Badian M, et al. Effect of forskolin eyedrops on intraocular pressure in healthy malesKlin Monbl Augenheilkd. (1984)