Skip to content
Literatúra
- Effect of the dietary supplement Meltdown on catecholamine secretion, markers of lipolysis, and metabolic rate in men and women: a randomized, placebo controlled, cross-over study.
- Singh DK, Srivastava B, Sahu A. Spectrophotometric determination of Rauwolfia alkaloids: estimation of reserpine in pharmaceuticals. Anal Sci. (2004)
- Cimolai N, Cimolai T. Yohimbine use for physical enhancement and its potential toxicity. J Diet Suppl. (2011)
- Rockhold RW, Gross F. Yohimbine diastereoisomers: cardiovascular effects after central and peripheral application in the rat. Naunyn Schmiedebergs Arch Pharmacol. (1981)
- Weitzell R, Tanaka T, Starke K. Pre- and postsynaptic effects of yohimbine stereoisomers on noradrenergic transmission in the pulmonary artery of the rabbit. Naunyn Schmiedebergs Arch Pharmacol. (1979)
- Material Safety Data Sheet for Yohimbine hydrochloride.
- Asker AF, Helal MA, Motawi MM. Light stability of some parenteral solutions of reserpine. Pharmazie. (1971)
- Jamil N, et al. Studies on the photostability of reserpine in parenteral solutions. Pharmazie. (1983)
- Strobl GR, et al. Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies. J Med Chem. (1993)
- Le Corre P, et al. Human sympathetic activation by alpha2-adrenergic blockade with yohimbine: Bimodal, epistatic influence of cytochrome P450-mediated drug metabolism. Clin Pharmacol Ther. (2004)
- Bharucha AE, et al. Relationship of cytochrome P450 pharmacogenetics to the effects of yohimbine on gastrointestinal transit and catecholamines in healthy subjects. Neurogastroenterol Motil. (2008)
- Ozawa S, et al. Ethnic differences in genetic polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1. Drug Metab Pharmacokinet. (2004)
- Taouis M, et al. Mechanism of the lipid-mobilizing effect of alpha-2 adrenergic antagonists in the dog. J Pharmacol Exp Ther. (1988)
- Szemeredi K, et al. Simultaneous measurement of plasma and brain extracellular fluid concentrations of catechols after yohimbine administration in rats. Brain Res. (1991)
- Ehlert U, et al. Salivary alpha-amylase levels after yohimbine challenge in healthy men. J Clin Endocrinol Metab. (2006)
- Meyerbroeker K, et al. Does yohimbine hydrochloride facilitate fear extinction in virtual reality treatment of fear of flying? A randomized placebo-controlled trial. Psychother Psychosom. (2012)
- Hedner T, et al. Yohimbine pharmacokinetics and interaction with the sympathetic nervous system in normal volunteers. Eur J Clin Pharmacol. (1992)
- Grossman E, et al. Oral yohimbine increases blood pressure and sympathetic nervous outflow in hypertensive patients. J Cardiovasc Pharmacol. (1993)
- Galitzky J, et al. Pharmacodynamic effects of chronic yohimbine treatment in healthy volunteers. Eur J Clin Pharmacol. (1990)
- Berlan M, et al. Plasma catecholamine levels and lipid mobilization induced by yohimbine in obese and non-obese women. Int J Obes. (1991)
- Sturgill MG, et al. Yohimbine elimination in normal volunteers is characterized by both one- and two-compartment behavior. J Cardiovasc Pharmacol. (1997)
- Mizuki Y, et al. Differential effects of noradrenergic drugs on anxiety and arousal in healthy volunteers with high and low anxiety. Prog Neuropsychopharmacol Biol Psychiatry. (1996)
- Kennedy SH, et al. Melatonin responses to clonidine and yohimbine challenges. J Psychiatry Neurosci. (1995)
- Arnsten AF. Toward a new understanding of attention-deficit hyperactivity disorder pathophysiology: an important role for prefrontal cortex dysfunction. CNS Drugs. (2009)
- Swanson CJ, et al. Effect of the attention deficit/hyperactivity disorder drug atomoxetine on extracellular concentrations of norepinephrine and dopamine in several brain regions of the rat. Neuropharmacology. (2006)
- Gronier B. In vivo electrophysiological effects of methylphenidate in the prefrontal cortex: involvement of dopamine D1 and alpha 2 adrenergic receptors. Eur Neuropsychopharmacol. (2011)
- Roychowdhury S, et al. α₂- and β-adrenoceptors involvement in nortriptyline modulation of auditory sustained attention and impulsivity. Psychopharmacology (Berl). (2012)
- Callahan MF, Beales M, Oltmans GA. Yohimbine and rauwolscine reduce food intake of genetically obese (obob) and lean mice. Pharmacol Biochem Behav. (1984)
- Jonderko K, Kucio C. Effect of anti-obesity drugs promoting energy expenditure, yohimbine and ephedrine, on gastric emptying in obese patients. Aliment Pharmacol Ther. (1991)
- Clark JT, Smith ER, Davidson JM. Evidence for the modulation of sexual behavior by alpha-adrenoceptors in male rats. Neuroendocrinology. (1985)
- Koskinen I, et al. Yohimbine and naloxone: effects on male rat sexual behavior. Physiol Behav. (1991)
- Clark JT, Smith ER, Davidson JM. Enhancement of sexual motivation in male rats by yohimbine. Science. (1984)
- Rodríguez-Manzo G, Fernández-Guasti A. Reversal of sexual exhaustion by serotonergic and noradrenergic agents. Behav Brain Res. (1994)
- Clark JT, Smith ER, Davidson JM. Testosterone is not required for the enhancement of sexual motivation by yohimbine. Physiol Behav. (1985)
- Travison TG, et al. The relationship between libido and testosterone levels in aging men. J Clin Endocrinol Metab. (2006)
- Guay AT, Jacobson J. Decreased free testosterone and dehydroepiandrosterone-sulfate (DHEA-S) levels in women with decreased libido. J Sex Marital Ther. (2002)
- Crespi F. Anxiolytics antagonize yohimbine-induced central noradrenergic activity: a concomitant in vivo voltammetry-electrophysiology model of anxiety. J Neurosci Methods. (2009)
- Charney DS, Heninger GR, Redmond DE Jr. Yohimbine induced anxiety and increased noradrenergic function in humans: effects of diazepam and clonidine. Life Sci. (1983)
- Stine SM, et al. Yohimbine-induced withdrawal and anxiety symptoms in opioid-dependent patients. Biol Psychiatry. (2002)
- Gurguis GN, Vitton BJ, Uhde TW. Behavioral, sympathetic and adrenocortical responses to yohimbine in panic disorder patients and normal controls. Psychiatry Res. (1997)
- Sommer M, et al. Psychological and neuroendocrine responses to social stress and to the administration of the alpha-2-receptor antagonist, yohimbine, in highly trained endurance athletes in comparison to untrained healthy controls. Pharmacopsychiatry. (2011)
- Rimmele U, et al. Trained men show lower cortisol, heart rate and psychological responses to psychosocial stress compared with untrained men. Psychoneuroendocrinology. (2007)
- Cameron OG, et al. Effects of yohimbine on cerebral blood flow, symptoms, and physiological functions in humans. Psychosom Med. (2000)
- Powers MB, et al. Facilitation of fear extinction in phobic participants with a novel cognitive enhancer: a randomized placebo controlled trial of yohimbine augmentation. J Anxiety Disord. (2009)
- Gentili A, et al. Effect of clonidine and yohimbine on sleep in healthy men: a double-blind, randomized, controlled trial. Eur J Clin Pharmacol. (1996)
- Anderson KJ, Revelle W. Impulsivity and time of day: is rate of change in arousal a function of impulsivity. J Pers Soc Psychol. (1994)
- Winstanley CA, Eagle DM, Robbins TW. Behavioral models of impulsivity in relation to ADHD: translation between clinical and preclinical studies. Clin Psychol Rev. (2006)
- Brennan AR, Arnsten AF. Neuronal mechanisms underlying attention deficit hyperactivity disorder: the influence of arousal on prefrontal cortical function. Ann N Y Acad Sci. (2008)
- Strawn JR, Geracioti TD Jr. Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder. Depress Anxiety. (2008)
- Casada JH, Roache JD. Behavioral inhibition and activation in posttraumatic stress disorder. J Nerv Ment Dis. (2005)
- Swann AC, et al. Acute yohimbine increases laboratory-measured impulsivity in normal subjects. Biol Psychiatry. (2005)
- Sun H, et al. Yohimbine increases impulsivity through activation of cAMP response element binding in the orbitofrontal cortex. Biol Psychiatry. (2010)
- Shamloul R. Natural aphrodisiacs. J Sex Med. (2010)
- Double Blind Trial of Yohimbine Hydrochloride in the Treatment of Erection Inadequacy.
- Morales A, et al. Is yohimbine effective in the treatment of organic impotence? Results of a controlled trial. J Urol. (1987)
- Mann K, et al. Effects of yohimbine on sexual experiences and nocturnal penile tumescence and rigidity in erectile dysfunction. Arch Sex Behav. (1996)
- Reid K, et al. Double-blind trial of yohimbine in treatment of psychogenic impotence. Lancet. (1987)
- Vogt HJ, et al. Double-blind, placebo-controlled safety and efficacy trial with yohimbine hydrochloride in the treatment of nonorganic erectile dysfunction. Int J Impot Res. (1997)
- Susset JG, et al. Effect of yohimbine hydrochloride on erectile impotence: a double-blind study. J Urol. (1989)
- Rowland DL, Kallan K, Slob AK. Yohimbine, erectile capacity, and sexual response in men. Arch Sex Behav. (1997)
- Kernohan AF, et al. An oral yohimbine/L-arginine combination (NMI 861) for the treatment of male erectile dysfunction: a pharmacokinetic, pharmacodynamic and interaction study with intravenous nitroglycerine in healthy male subjects. Br J Clin Pharmacol. (2005)
- Lebret T, et al. Efficacy and safety of a novel combination of L-arginine glutamate and yohimbine hydrochloride: a new oral therapy for erectile dysfunction. Eur Urol. (2002)
- Carmen GY, Víctor SM. Signalling mechanisms regulating lipolysis. Cell Signal. (2006)
- Liu CY, Boyer JL, Mills SE. Acute effects of beta-adrenergic agonists on porcine adipocyte metabolism in vitro. J Anim Sci. (1989)
- Lafontan M, et al. Alpha-2 adrenoceptors in lipolysis: alpha 2 antagonists and lipid-mobilizing strategies. Am J Clin Nutr. (1992)
- Doxey JC, et al. Comparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine. Naunyn Schmiedebergs Arch Pharmacol. (1984)
- Lalchandani SG, et al. Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype. J Pharmacol Exp Ther. (2002)
- MacDonald E, Kobilka BK, Scheinin M. Gene targeting–homing in on alpha 2-adrenoceptor-subtype function. Trends Pharmacol Sci. (1997)
- Tan S, Curtis-Prior PB. Comparative effects of RX 781094, mianserin, yohimbine, rauwolscine and prazosin in reversing clonidine inhibition of MIX-stimulated lipolysis in hamster isolated white fat cells. Pharmacol Res Commun. (1984)
- Reiner S, et al. Differential signaling of the endogenous agonists at the beta2-adrenergic receptor. J Biol Chem. (2010)
- Greenway FL, Bray GA, Heber D. Topical fat reduction. Obes Res. (1995)
- Greenway FL, Bray GA. Regional fat loss from the thigh in obese women after adrenergic modulation. Clin Ther. (1987)
- Pedersen SB, et al. Estrogen controls lipolysis by up-regulating alpha2A-adrenergic receptors directly in human adipose tissue through the estrogen receptor alpha. Implications for the female fat distribution. J Clin Endocrinol Metab. (2004)
- Keller U, Weiss M, Stauffacher W. Contribution of alpha- and beta-receptors to ketogenic and lipolytic effects of norepinephrine in humans. Diabetes. (1989)
- Galitzky J, et al. Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers. Eur J Clin Invest. (1988)
- McCarty MF. Pre-exercise administration of yohimbine may enhance the efficacy of exercise training as a fat loss strategy by boosting lipolysis. Med Hypotheses. (2002)
- Ito K, et al. Adrenoceptor antagonists, but not guanethidine, reduce glucopenia-induced glucagon secretion from perfused rat pancreas. Diabetes Res Clin Pract. (1995)
- Ribes G, et al. Involvement of a central nervous pathway in yohimbine-induced insulin secretion. Eur J Pharmacol. (1989)
- Ostojic SM. Yohimbine: the effects on body composition and exercise performance in soccer players. Res Sports Med. (2006)
- Sax L. Yohimbine does not affect fat distribution in men. Int J Obes. (1991)
- Biaggioni I, Robertson RM, Robertson D. Manipulation of norepinephrine metabolism with yohimbine in the treatment of autonomic failure. J Clin Pharmacol. (1994)
- Shibao C, et al. Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure. Hypertension. (2010)
- Sandberg M, et al. The α2-Adrenoceptor Antagonist Yohimbine Normalizes Increased Islet Blood Flow in GK Rats: A Model of Type 2 Diabetes. Horm Metab Res. (2012)
- Adeghate E, Ponery AS, Wahab A. Effect of electrical field stimulation on insulin and glucagon secretion from the pancreas of normal and diabetic rats. Horm Metab Res. (2001)
- Guay AT, et al. Yohimbine treatment of organic erectile dysfunction in a dose-escalation trial. Int J Impot Res. (2002)
- Cuneo RC, et al. Effects of alpha-2 adrenoreceptor blockade by yohimbine on the hormonal response to hypoglycaemic stress in normal man. Horm Metab Res. (1989)
- Krystal JH, et al. Serotonergic and noradrenergic dysregulation in alcoholism: m-chlorophenylpiperazine and yohimbine effects in recently detoxified alcoholics and healthy comparison subjects. Am J Psychiatry. (1996)
- McDougle CJ, et al. Noradrenergic response to acute ethanol administration in healthy subjects: comparison with intravenous yohimbine. Psychopharmacology (Berl). (1995)
- Mattila M, Seppala T, Mattila MJ. Anxiogenic effect of yohimbine in healthy subjects: comparison with caffeine and antagonism by clonidine and diazepam. Int Clin Psychopharmacol. (1988)
- Senbel AM, Mostafa T. Yohimbine enhances the effect of sildenafil on erectile process in rats. Int J Impot Res. (2008)
- Jordan J, Sharma AM. Potential for sibutramine-yohimbine interaction. Lancet. (2003)
- Waluga M, et al. Cardiovascular effects of ephedrine, caffeine and yohimbine measured by thoracic electrical bioimpedance in obese women. Clin Physiol. (1998)
- Schuckit MA. Subjective responses to alcohol in sons of alcoholics and control subjects. Arch Gen Psychiatry. (1984)
- Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother. (2010)
- Linden CH, Vellman WP, Rumack B. Yohimbine: a new street drug. Ann Emerg Med. (1985)
- HOLMBERG G, GERSHON S. Autonomic and psychic effects of yohimbine hydrochloride. Psychopharmacologia. (1961)
- Cohen PA, et al. Pharmaceutical quantities of yohimbine found in dietary supplements in the USA. Drug Test Anal. (2015)
- Giampreti A, et al. Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol (Phila). (2009)
- Ernst E, Pittler MH. Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials. J Urol. (1998)
- Umhau JC, et al. Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate. Neuropsychopharmacology. (2011)