1. Hattori A, et al. Identification of melatonin in plants and its effects on plasma melatonin levels and binding to melatonin receptors in vertebratesBiochem Mol Biol Int. (1995)
  2. Peuhkuri K, Sihvola N, Korpela R. Dietary factors and fluctuating levels of melatoninFood Nutr Res. (2012)
  3. Tan DX, et al. Functional roles of melatonin in plants, and perspectives in nutritional and agricultural scienceJ Exp Bot. (2012)
  4. Iriti M, Varoni EM, Vitalini S. Melatonin in traditional Mediterranean dietsJ Pineal Res. (2010)
  5. Determination of the melatonin content of different varieties of tomatoes (Lycopersicon esculentum) and strawberries (Fragariaananassa).
  6. Reiter RJ, Manchester LC, Tan DX. Melatonin in walnuts: influence on levels of melatonin and total antioxidant capacity of bloodNutrition. (2005)
  7. Melatonin is a phytochemical in olive oil.
  8. Diurnal pattern of melatonin in blood and milk of dairy Cows.
  9. Hormones in bovine milk and milk products: A survey.
  10. Valtonen M, et al. Effect of melatonin-rich night-time milk on sleep and activity in elderly institutionalized subjectsNord J Psychiatry. (2005)
  11. Melatonin: A new bioactive compound in wine.
  12. Maldonado MD, Moreno H, Calvo JR. Melatonin present in beer contributes to increase the levels of melatonin and antioxidant capacity of the human serumClin Nutr. (2009)
  13. Burkhardt S, et al. Detection and quantification of the antioxidant melatonin in Montmorency and Balaton tart cherries (Prunus cerasus)J Agric Food Chem. (2001)
  14. Chen G, et al. Melatonin in Chinese medicinal herbsLife Sci. (2003)
  15. Sanchez-Hidalgo M, et al. Melatonin inhibits fatty acid-induced triglyceride accumulation in ROS17/2.8 cells: implications for osteoblast differentiation and osteoporosisAm J Physiol Regul Integr Comp Physiol. (2007)
  16. Bernard M, et al. Melatonin synthesis pathway: circadian regulation of the genes encoding the key enzymes in the chicken pineal gland and retinaReprod Nutr Dev. (1999)
  17. Localization, Physiological Significance and Possible Clinical Implication of Gastrointestinal Melatonin.
  18. Bubenik GA, Konturek SJ. Melatonin and aging: prospects for human treatmentJ Physiol Pharmacol. (2011)
  19. Kollmann MT, et al. Effects of tryptophan supplementation on plasma tryptophan and related hormone levels in heifers and dairy cowsDomest Anim Endocrinol. (2008)
  20. Herrero MJ, et al. Response of plasma and gastrointestinal melatonin, plasma cortisol and activity rhythms of European sea bass (Dicentrarchus labrax) to dietary supplementation with tryptophan and melatoninJ Comp Physiol B. (2007)
  21. Hardeland R. Melatonin, hormone of darkness and more: occurrence, control mechanisms, actions and bioactive metabolitesCell Mol Life Sci. (2008)
  22. Klein DC. Arylalkylamine N-acetyltransferase: „the Timezyme“J Biol Chem. (2007)
  23. Reppert SM, Weaver DR, Ebisawa T. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responsesNeuron. (1994)
  24. Matsumoto M, et al. The amplitude of endogenous melatonin production is not affected by melatonin treatment in humansJ Pineal Res. (1997)
  25. Wright J, et al. The effects of exogenous melatonin on endocrine function in manClin Endocrinol (Oxf). (1986)
  26. Arendt J, et al. Some effects of melatonin and the control of its secretion in humansCiba Found Symp. (1985)
  27. Hack LM, et al. The effects of low-dose 0.5-mg melatonin on the free-running circadian rhythms of blind subjectsJ Biol Rhythms. (2003)
  28. Annual rhythm of serum melatonin in man.
  29. Dijk DJ, Duffy JF. Circadian regulation of human sleep and age-related changes in its timing, consolidation and EEG characteristicsAnn Med. (1999)
  30. Pang SF, Tang F, Tang PL. Negative correlation of age and the levels of pineal melatonin, pineal N-acetylserotonin, and serum melatonin in male ratsJ Exp Zool. (1984)
  31. Waldhauser F, Kovács J, Reiter E. Age-related changes in melatonin levels in humans and its potential consequences for sleep disordersExp Gerontol. (1998)
  32. Wetterberg L, et al. Normative melatonin excretion: a multinational studyPsychoneuroendocrinology. (1999)
  33. Benot S, et al. Physiological levels of melatonin contribute to the antioxidant capacity of human serumJ Pineal Res. (1999)
  34. Pandi-Perumal SR, et al. Melatonin and sleep in aging populationExp Gerontol. (2005)
  35. Reiter RJ. The pineal gland and melatonin in relation to aging: a summary of the theories and of the dataExp Gerontol. (1995)
  36. Nagata C, et al. Association of vegetable intake with urinary 6-sulfatoxymelatonin levelCancer Epidemiol Biomarkers Prev. (2005)
  37. Michalsen A, et al. Effects of short-term modified fasting on sleep patterns and daytime vigilance in non-obese subjects: results of a pilot studyAnn Nutr Metab. (2003)
  38. Röjdmark S, Rössner S, Wetterberg L. Effect of short-term fasting on nocturnal melatonin secretion in obesityMetabolism. (1992)
  39. Röjdmark S, Wetterberg L. Short-term fasting inhibits the nocturnal melatonin secretion in healthy manClin Endocrinol (Oxf). (1989)
  40. Stokkan KA, et al. Endocrine and metabolic effects of life-long food restriction in ratsActa Endocrinol (Copenh). (1991)
  41. Beck-Friis J, et al. Melatonin in relation to body measures, sex, age, season and the use of drugs in patients with major affective disorders and healthy subjectsPsychoneuroendocrinology. (1984)
  42. Tarquini B, et al. Daytime circulating melatonin levels in smokersTumori. (1994)
  43. Ozguner F, Koyu A, Cesur G. Active smoking causes oxidative stress and decreases blood melatonin levelsToxicol Ind Health. (2005)
  44. Ursing C, et al. Influence of cigarette smoking on melatonin levels in manEur J Clin Pharmacol. (2005)
  45. Schrenk D, et al. A distribution study of CYP1A2 phenotypes among smokers and nonsmokers in a cohort of healthy Caucasian volunteersEur J Clin Pharmacol. (1998)
  46. The Pineal Peptide Preparation, Epithalamin, Slows Aging in Drosophila melanogaster, Mice, and Rats.
  47. Anisimov VN, et al. Effect of melatonin and pineal peptide preparation epithalamin on life span and free radical oxidation in Drosophila melanogasterMech Ageing Dev. (1997)
  48. Korkushko OV, et al. Peptide geroprotector from the pituitary gland inhibits rapid aging of elderly people: results of 15-year follow-upBull Exp Biol Med. (2011)
  49. Mixon MB, et al. Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysisScience. (1995)
  50. Dubocovich ML, Markowska M. Functional MT1 and MT2 melatonin receptors in mammalsEndocrine. (2005)
  51. Reppert SM, Weaver DR, Godson C. Melatonin receptors step into the light: cloning and classification of subtypesTrends Pharmacol Sci. (1996)
  52. Roca AL, et al. Structure, characterization, and expression of the gene encoding the mouse Mel1a melatonin receptorEndocrinology. (1996)
  53. Dubocovich ML, et al. Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptorNaunyn Schmiedebergs Arch Pharmacol. (1997)
  54. Slaugenhaupt SA, et al. Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a)Genomics. (1995)
  55. Dubocovich ML, et al. Molecular pharmacology, regulation and function of mammalian melatonin receptorsFront Biosci. (2003)
  56. Masana MI, Dubocovich ML. Melatonin receptor signaling: finding the path through the darkSci STKE. (2001)
  57. Popova JS, Dubocovich ML. Melatonin receptor-mediated stimulation of phosphoinositide breakdown in chick brain slicesJ Neurochem. (1995)
  58. Nosjean O, et al. Identification of the melatonin-binding site MT3 as the quinone reductase 2J Biol Chem. (2000)
  59. Nosjean O, et al. Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2Biochem Pharmacol. (2001)
  60. Expression cloning of a high-affinity melatonin receptor from Xenopus dermal melanophores.
  61. Becker-André M, et al. Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamilyJ Biol Chem. (1994)
  62. Yasuo S, et al. Melatonin transmits photoperiodic signals through the MT1 melatonin receptorJ Neurosci. (2009)
  63. Ishii H, et al. Gene structures, biochemical characterization and distribution of rat melatonin receptorsJ Physiol Sci. (2009)
  64. Mühlbauer E, Peschke E. Evidence for the expression of both the MT1- and in addition, the MT2-melatonin receptor, in the rat pancreas, islet and beta-cellJ Pineal Res. (2007)
  65. Kazantzis M, et al. PAZ6 cells constitute a representative model for human brown pre-adipocytesFront Endocrinol (Lausanne). (2012)
  66. Reppert SM, et al. Cloning of a melatonin-related receptor from human pituitaryFEBS Lett. (1996)
  67. Bechtold DA, et al. A role for the melatonin-related receptor GPR50 in leptin signaling, adaptive thermogenesis, and torporCurr Biol. (2012)
  68. Sidibe A, et al. Expression of the orphan GPR50 protein in rodent and human dorsomedial hypothalamus, tanycytes and median eminenceJ Pineal Res. (2010)
  69. Ivanova EA, et al. Altered metabolism in the melatonin-related receptor (GPR50) knockout mouseAm J Physiol Endocrinol Metab. (2008)
  70. Swoap SJ. Thermoregulation: an orphan receptor finds its way in the coldCurr Biol. (2012)
  71. Jockers R, et al. Melatonin receptors, heterodimerization, signal transduction and binding sites: what’s newBr J Pharmacol. (2008)
  72. Levoye A, et al. The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerizationEMBO J. (2006)
  73. Mundey K, et al. Phase-dependent treatment of delayed sleep phase syndrome with melatoninSleep. (2005)
  74. Melatonin Treatment for Age-Related Insomnia.
  75. Low, but not high, doses of melatonin entrained a free-running blind person with a long circadian period.
  76. Sack RL, et al. Entrainment of free-running circadian rhythms by melatonin in blind peopleN Engl J Med. (2000)
  77. Dawson D, Gibbon S, Singh P. The hypothermic effect of melatonin on core body temperature: is more betterJ Pineal Res. (1996)
  78. Meeking DR, et al. Exercise-induced GH secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjectsEur J Endocrinol. (1999)
  79. Mero AA, et al. Effects of resistance exercise session after oral ingestion of melatonin on physiological and performance responses of adult menEur J Appl Physiol. (2006)
  80. Cagnacci A, Soldani R, Yen SS. Melatonin enhances cortisol levels in aged women: reversible by estrogensJ Pineal Res. (1997)
  81. Cagnacci A, Elliott JA, Yen SS. Amplification of pulsatile LH secretion by exogenous melatonin in womenJ Clin Endocrinol Metab. (1991)
  82. Waldhauser F, et al. Bioavailability of oral melatonin in humansNeuroendocrinology. (1984)
  83. Markantonis SL, et al. Melatonin pharmacokinetics in premenopausal and postmenopausal healthy female volunteersJ Clin Pharmacol. (2008)
  84. Wetterberg L, et al. A simplified radioimmunoassay for melatonin and its application to biological fluids. Preliminary observations on the half-life of plasma melatonin in manClin Chim Acta. (1978)
  85. Bechgaard E, Lindhardt K, Martinsen L. Intranasal absorption of melatonin in vivo bioavailability studyInt J Pharm. (1999)
  86. Ma X, et al. Metabolism of melatonin by human cytochromes p450Drug Metab Dispos. (2005)
  87. Facciolá G, et al. Cytochrome P450 isoforms involved in melatonin metabolism in human liver microsomesEur J Clin Pharmacol. (2001)
  88. Skene DJ, et al. Contribution of CYP1A2 in the hepatic metabolism of melatonin: studies with isolated microsomal preparations and liver slicesJ Pineal Res. (2001)
  89. Grözinger M, et al. Fluvoxamine strongly inhibits melatonin metabolism in a patient with low-amplitude melatonin profileArch Gen Psychiatry. (2000)
  90. Härtter S, et al. Increased bioavailability of oral melatonin after fluvoxamine coadministrationClin Pharmacol Ther. (2000)
  91. Rimmele U, et al. Melatonin improves memory acquisition under stress independent of stress hormone releasePsychopharmacology (Berl). (2009)
  92. Arangino S, et al. Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy menAm J Cardiol. (1999)
  93. Nishiyama K, et al. Acute effects of melatonin administration on cardiovascular autonomic regulation in healthy menAm Heart J. (2001)
  94. Cagnacci A, et al. Influences of melatonin administration on the circulation of womenAm J Physiol. (1998)
  95. Zisapel N, Laudon M. Dopamine release induced by electrical field stimulation of rat hypothalamus in vitro: inhibition by melatoninBiochem Biophys Res Commun. (1982)
  96. Zisapel N, Egozi Y, Laudon M. Inhibition of dopamine release by melatonin: regional distribution in the rat brainBrain Res. (1982)
  97. Zisapel N, Laudon M. Inhibition by melatonin of dopamine release from rat hypothalamus: regulation of calcium entryBrain Res. (1983)
  98. Escames G, et al. Calcium-dependent effects of melatonin inhibition of glutamatergic response in rat striatumJ Neuroendocrinol. (2001)
  99. Shieh KR, Chu YS, Pan JT. Circadian change of dopaminergic neuron activity: effects of constant light and melatoninNeuroreport. (1997)
  100. Zisapel N. Melatonin-dopamine interactions: from basic neurochemistry to a clinical settingCell Mol Neurobiol. (2001)
  101. Exposito I, Mora F, Oaknin S. Dopamine-glutamic acid interaction in the anterior hypothalamus: modulatory effect of melatoninNeuroreport. (1995)
  102. Exposito I, et al. The modulatory effect of melatonin on the dopamine-glutamate interaction in the anterior hypothalamus during ageingNeuroreport. (1995)
  103. Jin X, et al. Targeted disruption of the mouse Mel(1b) melatonin receptorMol Cell Biol. (2003)
  104. von Gall C, et al. Melatonin limits transcriptional impact of phosphoCREB in the mouse SCN via the Mel1a receptorNeuroreport. (2000)
  105. Activation of MT2 melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock.
  106. Kunz D, et al. Melatonin in patients with reduced REM sleep duration: two randomized controlled trialsJ Clin Endocrinol Metab. (2004)
  107. Dubocovich ML. Melatonin receptors: role on sleep and circadian rhythm regulationSleep Med. (2007)
  108. Dubocovich ML, et al. Effect of MT1 melatonin receptor deletion on melatonin-mediated phase shift of circadian rhythms in the C57BL/6 mouseJ Pineal Res. (2005)
  109. McArthur AJ, Hunt AE, Gillette MU. Melatonin action and signal transduction in the rat suprachiasmatic circadian clock: activation of protein kinase C at dusk and dawnEndocrinology. (1997)
  110. Shibata S, Cassone VM, Moore RY. Effects of melatonin on neuronal activity in the rat suprachiasmatic nucleus in vitroNeurosci Lett. (1989)
  111. Liu C, et al. Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clockNeuron. (1997)
  112. Forsling ML, Williams AJ. The effect of exogenous melatonin on stimulated neurohypophysial hormone release in manClin Endocrinol (Oxf). (2002)
  113. Forsling ML, Wheeler MJ, Williams AJ. The effect of melatonin administration on pituitary hormone secretion in manClin Endocrinol (Oxf). (1999)
  114. Kostoglou-Athanassiou I, et al. Melatonin administration and pituitary hormone secretionClin Endocrinol (Oxf). (1998)
  115. Wang JZ, Wang ZF. Role of melatonin in Alzheimer-like neurodegenerationActa Pharmacol Sin. (2006)
  116. Koh PO. Melatonin prevents ischemic brain injury through activation of the mTOR/p70S6 kinase signaling pathwayNeurosci Lett. (2008)
  117. Kongsuphol P, et al. Melatonin attenuates methamphetamine-induced deactivation of the mammalian target of rapamycin signaling to induce autophagy in SK-N-SH cellsJ Pineal Res. (2009)
  118. Kimball SR, Abbas A, Jefferson LS. Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of RasJ Pineal Res. (2008)
  119. Kwon KJ, et al. Melatonin Potentiates the Neuroprotective Properties of Resveratrol Against Beta-Amyloid-Induced Neurodegeneration by Modulating AMP-Activated Protein Kinase PathwaysJ Clin Neurol. (2010)
  120. Gagnier JJ. The therapeutic potential of melatonin in migraines and other headache typesAltern Med Rev. (2001)
  121. Alstadhaug K, Salvesen R, Bekkelund S. 24-hour distribution of migraine attacksHeadache. (2008)
  122. Alstadhaug K, Salvesen R, Bekkelund S. Insomnia and circadian variation of attacks in episodic migraineHeadache. (2007)
  123. Alstadhaug KB, et al. Prophylaxis of migraine with melatonin: a randomized controlled trialNeurology. (2010)
  124. Peres MF. Melatonin for migraine preventionCurr Pain Headache Rep. (2011)
  125. Seabra ML, et al. Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatmentJ Pineal Res. (2000)
  126. Ferini-Strambi L, et al. Effect of melatonin on sleep microstructure: preliminary results in healthy subjectsSleep. (1993)
  127. James SP, et al. The effect of melatonin on normal sleepNeuropsychopharmacology. (1987)
  128. Cramer H, et al. On the effects of melatonin on sleep and behavior in manAdv Biochem Psychopharmacol. (1974)
  129. Waldhauser F, Saletu B, Trinchard-Lugan I. Sleep laboratory investigations on hypnotic properties of melatoninPsychopharmacology (Berl). (1990)
  130. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance.
  131. Nave R, Peled R, Lavie P. Melatonin improves evening nappingEur J Pharmacol. (1995)
  132. Reid K, Van den Heuvel C, Dawson D. Day-time melatonin administration: effects on core temperature and sleep onset latencyJ Sleep Res. (1996)
  133. Zhdanova IV, et al. Sleep-inducing effects of low doses of melatonin ingested in the eveningClin Pharmacol Ther. (1995)
  134. Zhdanova IV, et al. Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humansSleep. (1996)
  135. Pinto LR Jr, Seabra Mde L, Tufik S. Different criteria of sleep latency and the effect of melatonin on sleep consolidationSleep. (2004)
  136. Wade AG, et al. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safetyBMC Med. (2010)
  137. Wade AG, et al. Prolonged release melatonin in the treatment of primary insomnia: evaluation of the age cut-off for short- and long-term responseCurr Med Res Opin. (2011)
  138. Lemoine P, et al. Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effectsJ Sleep Res. (2007)
  139. Luthringer R, et al. The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomniaInt Clin Psychopharmacol. (2009)
  140. van Geijlswijk IM, et al. Evaluation of sleep, puberty and mental health in children with long-term melatonin treatment for chronic idiopathic childhood sleep onset insomniaPsychopharmacology (Berl). (2011)
  141. Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boysArch Dis Child. (1970)
  142. Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girlsArch Dis Child. (1969)
  143. Hurtuk A, et al. Melatonin: can it stop the ringingAnn Otol Rhinol Laryngol. (2011)
  144. Requintina PJ, et al. Synergistic sedative effect of selective MAO-A, but not MAO-B, inhibitors and melatonin in frogsJ Neural Transm Suppl. (1994)
  145. Rajaratnam SM, Arendt J. Health in a 24-h societyLancet. (2001)
  146. Kiessling S, Eichele G, Oster H. Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lagJ Clin Invest. (2010)
  147. Efficacy of Melatonin Treatment in Jet Lag, Shift Work, and Blindness.
  148. Pfeffer M, et al. The endogenous melatonin (MT) signal facilitates reentrainment of the circadian system to light-induced phase advances by acting upon MT2 receptorsChronobiol Int. (2012)
  149. Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lagCochrane Database Syst Rev. (2002)
  150. Spitzer RL, et al. Jet lag: clinical features, validation of a new syndrome-specific scale, and lack of response to melatonin in a randomized, double-blind trialAm J Psychiatry. (1999)
  151. Suhner A, et al. Effectiveness and tolerability of melatonin and zolpidem for the alleviation of jet lagAviat Space Environ Med. (2001)
  152. Beaumont M, et al. Caffeine or melatonin effects on sleep and sleepiness after rapid eastward transmeridian travelJ Appl Physiol. (2004)
  153. Petrie K, et al. A double-blind trial of melatonin as a treatment for jet lag in international cabin crewBiol Psychiatry. (1993)
  154. Claustrat B, et al. Melatonin and jet lag: confirmatory result using a simplified protocolBiol Psychiatry. (1992)
  155. Piérard C, et al. Resynchronization of hormonal rhythms after an eastbound flight in humans: effects of slow-release caffeine and melatoninEur J Appl Physiol. (2001)
  156. Edwards BJ, et al. Use of melatonin in recovery from jet-lag following an eastward flight across 10 time-zonesErgonomics. (2000)
  157. Sharkey KM, Eastman CI. Melatonin phase shifts human circadian rhythms in a placebo-controlled simulated night-work studyAm J Physiol Regul Integr Comp Physiol. (2002)
  158. Samel A, et al. Influence of melatonin treatment on human circadian rhythmicity before and after a simulated 9-hr time shiftJ Biol Rhythms. (1991)
  159. Paul MA, et al. Phase advance with separate and combined melatonin and light treatmentPsychopharmacology (Berl). (2011)
  160. Preflight Adjustment to Eastward Travel: 3 Days of Advancing Sleep with and without Morning Bright Light.
  161. Revell VL, et al. Advancing human circadian rhythms with afternoon melatonin and morning intermittent bright lightJ Clin Endocrinol Metab. (2006)
  162. Wirz-Justice A, et al. Evening melatonin and bright light administration induce additive phase shifts in dim light melatonin onsetJ Pineal Res. (2004)
  163. Kitaoka K, et al. Fermented ginseng improves the first-night effect in humansSleep. (2009)
  165. Shamir E, et al. First-night effect of melatonin treatment in patients with chronic schizophreniaJ Clin Psychopharmacol. (2000)
  166. Shamir E, et al. Melatonin improves sleep quality of patients with chronic schizophreniaJ Clin Psychiatry. (2000)
  167. Lewy AJ, et al. Antidepressant and circadian phase-shifting effects of lightScience. (1987)
  168. Teicher MH, et al. Circadian rest-activity disturbances in seasonal affective disorderArch Gen Psychiatry. (1997)
  169. Lewy AJ, et al. The circadian basis of winter depressionProc Natl Acad Sci U S A. (2006)
  170. Lewy AJ, et al. The human phase response curve (PRC) to melatonin is about 12 hours out of phase with the PRC to lightChronobiol Int. (1998)
  171. Biology of Depression: From Novel Insights to Therapeutic Strategies.
  172. Rondanelli M, et al. Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairmentNutr Neurosci. (2012)
  173. Genade S, et al. Melatonin receptor-mediated protection against myocardial ischaemia/reperfusion injury: role of its anti-adrenergic actionsJ Pineal Res. (2008)
  174. Cook JS, Sauder CL, Ray CA. Melatonin differentially affects vascular blood flow in humansAm J Physiol Heart Circ Physiol. (2011)
  175. Koziróg M, et al. Melatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metabolic syndromeJ Pineal Res. (2011)
  176. Maldonado MD, et al. Melatonin administered immediately before an intense exercise reverses oxidative stress, improves immunological defenses and lipid metabolism in football playersPhysiol Behav. (2012)
  177. Celinski K, et al. Melatonin or L-tryptophan accelerates healing of gastroduodenal ulcers in patients treated with omeprazoleJ Pineal Res. (2011)
  178. Gonciarz M, et al. Plasma insulin, leptin, adiponectin, resistin, ghrelin, and melatonin in nonalcoholic steatohepatitis patients treated with melatoninJ Pineal Res. (2012)
  179. Ríos-Lugo MJ, et al. Melatonin effect on plasma adiponectin, leptin, insulin, glucose, triglycerides and cholesterol in normal and high fat-fed ratsJ Pineal Res. (2010)
  180. Song YM, Chen MD. Effects of melatonin administration on plasma leptin concentration and adipose tissue leptin secretion in miceActa Biol Hung. (2009)
  181. Baltaci AK, Mogulkoc R. Pinealectomy and melatonin administration in rats: their effects on plasma leptin levels and relationship with zincActa Biol Hung. (2007)
  182. Alonso-Vale MI, et al. Melatonin enhances leptin expression by rat adipocytes in the presence of insulinAm J Physiol Endocrinol Metab. (2005)
  183. Alonso-Vale MI, et al. Intermittent and rhythmic exposure to melatonin in primary cultured adipocytes enhances the insulin and dexamethasone effects on leptin expressionJ Pineal Res. (2006)
  184. Borges-Silva CN, et al. Reduced lipolysis and increased lipogenesis in adipose tissue from pinealectomized rats adapted to trainingJ Pineal Res. (2005)
  185. Zhang L, et al. Melatonin inhibits adipogenesis and enhances osteogenesis of human mesenchymal stem cells by suppressing PPARγ expression and enhancing Runx2 expressionJ Pineal Res. (2010)
  186. Alonso-Vale MI, et al. Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBPbeta transcriptional activityJ Pineal Res. (2009)
  187. Zwirska-Korczala K, et al. Influence of melatonin on cell proliferation, antioxidative enzyme activities and lipid peroxidation in 3T3-L1 preadipocytes–an in vitro studyJ Physiol Pharmacol. (2005)
  188. Zalatan F, Krause JA, Blask DE. Inhibition of isoproterenol-induced lipolysis in rat inguinal adipocytes in vitro by physiological melatonin via a receptor-mediated mechanismEndocrinology. (2001)
  189. Wolden-Hanson T, et al. Daily melatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fatEndocrinology. (2000)
  190. Stratos I, et al. Melatonin restores muscle regeneration and enhances muscle function after crush injury in ratsJ Pineal Res. (2012)
  191. Wang WZ, et al. Melatonin attenuates I/R-induced mitochondrial dysfunction in skeletal muscleJ Surg Res. (2011)
  192. Hibaoui Y, Roulet E, Ruegg UT. Melatonin prevents oxidative stress-mediated mitochondrial permeability transition and death in skeletal muscle cellsJ Pineal Res. (2009)
  193. Atkinson G, et al. Are there hangover-effects on physical performance when melatonin is ingested by athletes before nocturnal sleepInt J Sports Med. (2001)
  194. Atkinson G, et al. Effects of daytime ingestion of melatonin on short-term athletic performanceErgonomics. (2005)
  195. Schernhammer ES, et al. A randomized controlled trial of oral melatonin supplementation and breast cancer biomarkersCancer Causes Control. (2012)
  196. Cos S, et al. Melatonin modulates aromatase activity in MCF-7 human breast cancer cellsJ Pineal Res. (2005)
  197. González A, et al. Effects of MT1 melatonin receptor overexpression on the aromatase-suppressive effect of melatonin in MCF-7 human breast cancer cellsOncol Rep. (2007)
  198. Girgert R, et al. Membrane-bound melatonin receptor MT1 down-regulates estrogen responsive genes in breast cancer cellsJ Pineal Res. (2009)
  199. Knower KC, et al. Melatonin suppresses aromatase expression and activity in breast cancer associated fibroblastsBreast Cancer Res Treat. (2012)
  200. Frungieri MB, et al. Direct effect of melatonin on Syrian hamster testes: melatonin subtype 1a receptors, inhibition of androgen production, and interaction with the local corticotropin-releasing hormone systemEndocrinology. (2005)
  201. Dufau ML, Tinajero JC, Fabbri A. Corticotropin-releasing factor: an antireproductive hormone of the testisFASEB J. (1993)
  202. Rossi SP, et al. New insights into melatonin/CRH signaling in hamster Leydig cellsGen Comp Endocrinol. (2012)
  203. Frungieri MB, Gonzalez-Calvar SI, Calandra RS. Polyamine levels in testes and seminal vesicles from adult golden hamsters during gonadal regression-recrudescenceJ Androl. (1996)
  204. Valcavi R, et al. Melatonin stimulates growth hormone secretion through pathways other than the growth hormone-releasing hormoneClin Endocrinol (Oxf). (1993)
  205. Smythe GA, Lazarus L. Suppression of human growth hormone secretion by melatonin and cyproheptadineJ Clin Invest. (1974)
  206. Nassar E, et al. Effects of a single dose of N-Acetyl-5-methoxytryptamine (Melatonin) and resistance exercise on the growth hormone/IGF-1 axis in young males and femalesJ Int Soc Sports Nutr. (2007)
  207. Melatonin As a Free Radical Scavenger: Implications for Aging and Age-Related Diseases.
  208. Allegra M, et al. The chemistry of melatonin’s interaction with reactive speciesJ Pineal Res. (2003)
  209. Reiter RJ, et al. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidenceCell Biochem Biophys. (2001)
  210. Poeggeler B, et al. Melatonin–a highly potent endogenous radical scavenger and electron donor: new aspects of the oxidation chemistry of this indole accessed in vitroAnn N Y Acad Sci. (1994)
  211. Reaction of Melatonin and Related Indoles With Hydroxyl Radicals: EPR and Spin Trapping Investigations.
  212. Noda Y, et al. Melatonin and its precursors scavenge nitric oxideJ Pineal Res. (1999)
  213. Zhang H, Squadrito GL, Pryor WA. The reaction of melatonin with peroxynitrite: formation of melatonin radical cation and absence of stable nitrated productsBiochem Biophys Res Commun. (1998)
  214. López-Burillo S, et al. Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: a study of their individual and synergistic actionsJ Pineal Res. (2003)
  215. Kandil TS, et al. The potential therapeutic effect of melatonin in Gastroesophageal Reflux DiseaseBMC Gastroenterol. (2010)
  216. Celinski K, et al. Effects of melatonin and tryptophan on healing of gastric and duodenal ulcers with Helicobacter pylori infection in humansJ Physiol Pharmacol. (2011)
  217. Melatonin orl-tryptophan accelerates healing of gastroduodenal ulcers in patients treated with omeprazole.
  218. Konturek PC, et al. Role of melatonin in mucosal gastroprotection against aspirin-induced gastric lesions in humansJ Pineal Res. (2010)
  219. Osborne NN, Chidlow G. The presence of functional melatonin receptors in the iris-ciliary processes of the rabbit eyeExp Eye Res. (1994)
  220. Alarma-Estrany P, et al. Sympathetic nervous system modulates the ocular hypotensive action of MT2-melatonin receptors in normotensive rabbitsJ Pineal Res. (2008)
  221. Wiechmann AF, Wirsig-Wiechmann CR. Melatonin receptor mRNA and protein expression in Xenopus laevis nonpigmented ciliary epithelial cellsExp Eye Res. (2001)
  222. Samples JR, Krause G, Lewy AJ. Effect of melatonin on intraocular pressureCurr Eye Res. (1988)
  223. Ismail SA, Mowafi HA. Melatonin provides anxiolysis, enhances analgesia, decreases intraocular pressure, and promotes better operating conditions during cataract surgery under topical anesthesiaAnesth Analg. (2009)
  224. Crooke A, et al. Regulation of ocular adrenoceptor genes expression by 5-MCA-NAT: implications for glaucoma treatmentPharmacogenet Genomics. (2011)
  225. Crooke A, et al. Involvement of carbonic anhydrases in the ocular hypotensive effect of melatonin analogue 5-MCA-NATJ Pineal Res. (2012)
  226. Chiquet C, et al. Melatonin concentrations in aqueous humor of glaucoma patientsAm J Ophthalmol. (2006)
  227. Yu HS, et al. Diurnal rhythms of immunoreactive melatonin in the aqueous humor and serum of male pigmented rabbitsNeurosci Lett. (1990)
  228. Mediero A, Alarma-Estrany P, Pintor J. New treatments for ocular hypertensionAuton Neurosci. (2009)
  229. Yi C, et al. Effects of melatonin in age-related macular degenerationAnn N Y Acad Sci. (2005)
  230. Rosenberg SI, et al. Effect of melatonin on tinnitusLaryngoscope. (1998)
  231. Megwalu UC, Finnell JE, Piccirillo JF. The effects of melatonin on tinnitus and sleepOtolaryngol Head Neck Surg. (2006)
  232. Neri G, et al. Treatment of central and sensorineural tinnitus with orally administered Melatonin and Sulodexide: personal experience from a randomized controlled studyActa Otorhinolaryngol Ital. (2009)
  233. Neri G, et al. Management of tinnitus: oral treatment with melatonin and sulodexideJ Biol Regul Homeost Agents. (2009)
  234. Zakian VA. Telomeres: beginning to understand the endScience. (1995)
  235. Harley CB, Villeponteau B. Telomeres and telomerase in aging and cancerCurr Opin Genet Dev. (1995)
  236. Leon-Blanco MM, et al. RNA expression of human telomerase subunits TR and TERT is differentially affected by melatonin receptor agonists in the MCF-7 tumor cell lineCancer Lett. (2004)
  237. Akbulut KG, Gonul B, Akbulut H. The role of melatonin on gastric mucosal cell proliferation and telomerase activity in ageingJ Pineal Res. (2009)
  238. Kirkpatrick KL, et al. hTERT mRNA expression correlates with telomerase activity in human breast cancerEur J Surg Oncol. (2003)
  239. Bayne S, Liu JP. Hormones and growth factors regulate telomerase activity in ageing and cancerMol Cell Endocrinol. (2005)
  240. Estrogen Activates Telomerase.
  241. Martínez-Campa CM, et al. Melatonin down-regulates hTERT expression induced by either natural estrogens (17beta-estradiol) or metalloestrogens (cadmium) in MCF-7 human breast cancer cellsCancer Lett. (2008)
  242. Shay JW, Bacchetti S. A survey of telomerase activity in human cancerEur J Cancer. (1997)
  243. Reiter RJ. Mechanisms of cancer inhibition by melatoninJ Pineal Res. (2004)
  244. Leon-Blanco MM, et al. Melatonin inhibits telomerase activity in the MCF-7 tumor cell line both in vivo and in vitroJ Pineal Res. (2003)
  245. Mills E, et al. Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysisJ Pineal Res. (2005)
  246. Vijayalaxmi, et al. Melatonin: from basic research to cancer treatment clinicsJ Clin Oncol. (2002)
  247. Viswanathan AN, Schernhammer ES. Circulating melatonin and the risk of breast and endometrial cancer in womenCancer Lett. (2009)
  248. Srinivasan V, et al. Melatonin, environmental light, and breast cancerBreast Cancer Res Treat. (2008)
  249. Korkmaz A, et al. Role of melatonin in the epigenetic regulation of breast cancerBreast Cancer Res Treat. (2009)
  250. Persson C, et al. Impact of fish oil and melatonin on cachexia in patients with advanced gastrointestinal cancer: a randomized pilot studyNutrition. (2005)
  251. Pineal control of aging: effect of melatonin and pineal grafting on aging mice.
  252. The Pineal Aging and Death Program. I. Grafting of Old Pineals in Young Mice Accelerates Their Aging.
  253. Stokkan KA, et al. Food restriction retards aging of the pineal glandBrain Res. (1991)
  254. Reiter RJ. The melatonin rhythm: both a clock and a calendarExperientia. (1993)
  255. Ferrari E, et al. Neuroendocrine features in extreme longevityExp Gerontol. (2008)
  256. Acuña-Castroviejo D, et al. Melatonin protects lung mitochondria from agingAge (Dordr). (2011)
  257. Pineal control of aging: Effect of melatonin and pineal grafting on aging mice.
  258. Forman K, et al. Effect of a combined treatment with growth hormone and melatonin in the cardiological aging on male SAMP8 miceJ Gerontol A Biol Sci Med Sci. (2011)
  259. Rodríguez MI, et al. Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated miceFree Radic Res. (2007)
  260. Forman K, et al. Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated agingJ Pineal Res. (2010)
  261. Tresguerres JA, et al. Effect of chronic melatonin administration on several physiological parameters from old wistar rats and samp8 miceCurr Aging Sci. (2012)
  262. Cuesta S, et al. Beneficial effect of melatonin treatment on inflammation, apoptosis and oxidative stress on pancreas of a senescence accelerated mice modelMech Ageing Dev. (2011)
  263. Cuesta S, et al. Melatonin improves inflammation processes in liver of senescence-accelerated prone male mice (SAMP8)Exp Gerontol. (2010)
  264. Morreale M, Livrea MA. Synergistic effect of glycolic acid on the antioxidant activity of alpha-tocopherol and melatonin in lipid bilayers and in human skin homogenatesBiochem Mol Biol Int. (1997)
  265. Oxidative Stress in Ageing of Hair.
  266. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated with p16INK4a Expression.
  267. Tan DX, et al. Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavengerCurr Top Med Chem. (2002)
  268. Reiter RJ, et al. Melatonin as a free radical scavenger: implications for aging and age-related diseasesAnn N Y Acad Sci. (1994)
  269. Kobayashi H, et al. A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptorsFASEB J. (2005)
  270. Fischer TW, et al. Melatonin and the hair follicleJ Pineal Res. (2008)
  271. Fischer TW, et al. Topical melatonin for treatment of androgenetic alopeciaInt J Trichology. (2012)
  272. Fischer TW, et al. Melatonin increases anagen hair rate in women with androgenetic alopecia or diffuse alopecia: results of a pilot randomized controlled trialBr J Dermatol. (2004)
  273. Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity.
  274. Dragicevic N, et al. Caffeine increases mitochondrial function and blocks melatonin signaling to mitochondria in Alzheimer’s mice and cellsNeuropharmacology. (2012)
  275. Ekman AC, et al. Ethanol inhibits melatonin secretion in healthy volunteers in a dose-dependent randomized double blind cross-over studyJ Clin Endocrinol Metab. (1993)
  276. Rupp TL, Acebo C, Carskadon MA. Evening alcohol suppresses salivary melatonin in young adultsChronobiol Int. (2007)
  277. Röjdmark S, et al. Inhibition of melatonin secretion by ethanol in manMetabolism. (1993)
  278. Hartman TJ, et al. Moderate alcohol consumption and 24-hour urinary levels of melatonin in postmenopausal womenJ Clin Endocrinol Metab. (2012)
  279. Stevens RG, et al. Alcohol consumption and urinary concentration of 6-sulfatoxymelatonin in healthy womenEpidemiology. (2000)
  280. Walsh HA, Daya S, Whiteley CG. Mode of inhibition of rat liver tryptophan 2,3-dioxygenase by melatoninJ Pineal Res. (1994)
  281. Park K, et al. Synergistic effect of melatonin on exercise-induced neuronal reconstruction and functional recovery in a spinal cord injury animal modelJ Pineal Res. (2010)
  282. García-Mesa Y, et al. Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouseNeurobiol Aging. (2012)
  283. Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles.
  284. Ahmad A, et al. Synergistic effect of selenium and melatonin on neuroprotection in cerebral ischemia in ratsBiol Trace Elem Res. (2011)
  285. Romero A, et al. Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cellsJ Pineal Res. (2010)
  286. Waldhauser F, et al. A pharmacological dose of melatonin increases PRL levels in males without altering those of GH, LH, FSH, TSH, testosterone or cortisolNeuroendocrinology. (1987)
  287. Valcavi R, et al. Effect of oral administration of melatonin on GH responses to GRF 1-44 in normal subjectsClin Endocrinol (Oxf). (1987)
  288. Weinberg U, et al. Lack of an effect of melatonin on the basal and L-dopa stimulated growth hormone secretion in menJ Neural Transm. (1981)
  289. Carr R, et al. Long-term effectiveness outcome of melatonin therapy in children with treatment-resistant circadian rhythm sleep disordersJ Pineal Res. (2007)
  290. Lemoine P, et al. Prolonged-release melatonin for insomnia – an open-label long-term study of efficacy, safety, and withdrawalTher Clin Risk Manag. (2011)
  291. Pierrefiche G, Zerbib R, Laborit H. Anxiolytic activity of melatonin in mice: involvement of benzodiazepine receptorsRes Commun Chem Pathol Pharmacol. (1993)
  292. Golombek DA, Martini M, Cardinali DP. Melatonin as an anxiolytic in rats: time dependence and interaction with the central GABAergic systemEur J Pharmacol. (1993)
  293. Hoebert M, et al. Long-term follow-up of melatonin treatment in children with ADHD and chronic sleep onset insomniaJ Pineal Res. (2009)
  294. van Maanen A, et al. Termination of short term melatonin treatment in children with delayed Dim Light Melatonin Onset: effects on sleep, health, behavior problems, and parenting stressSleep Med. (2011)
  295. Leibenluft E, et al. Effects of exogenous melatonin administration and withdrawal in five patients with rapid-cycling bipolar disorderJ Clin Psychiatry. (1997)
  296. Wade AG, et al. Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomesCurr Med Res Opin. (2007)
  297. Schernhammer ES, et al. Urinary 6-Sulphatoxymelatonin levels and risk of breast cancer in premenopausal women: the ORDET cohortCancer Epidemiol Biomarkers Prev. (2010)
  298. Ochoa JJ, et al. Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human malesJ Pineal Res. (2011)
  299. Xie L, et al. Sleep drives metabolite clearance from the adult brainScience. (2013)
  300. Rasch B, Born J. About sleep’s role in memoryPhysiol Rev. (2013)
  301. Born J, Rasch B, Gais S. Sleep to rememberNeuroscientist. (2006)
  302. Haack M, Sanchez E, Mullington JM. Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteersSleep. (2007)
  303. Alhola P, Polo-Kantola P. Sleep deprivation: Impact on cognitive performanceNeuropsychiatr Dis Treat. (2007)
  304. Nedeltcheva AV, et al. Insufficient sleep undermines dietary efforts to reduce adiposityAnn Intern Med. (2010)
  305. Bosy-Westphal A, et al. Influence of partial sleep deprivation on energy balance and insulin sensitivity in healthy womenObes Facts. (2008)
  306. Broussard JL, et al. Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover studyAnn Intern Med. (2012)
  307. Buxton OM, et al. Sleep restriction for 1 week reduces insulin sensitivity in healthy menDiabetes. (2010)
  308. Donga E, et al. A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjectsJ Clin Endocrinol Metab. (2010)
  309. Cote KA, et al. Sleep deprivation lowers reactive aggression and testosterone in menBiol Psychol. (2013)
  310. Leproult R, Van Cauter E. Effect of 1 week of sleep restriction on testosterone levels in young healthy menJAMA. (2011)
  311. Penev PD. Association between sleep and morning testosterone levels in older menSleep. (2007)
  312. González-Santos MR, et al. Sleep deprivation and adaptive hormonal responses of healthy menArch Androl. (1989)
  313. Cortés-Gallegos V, et al. Sleep deprivation reduces circulating androgens in healthy menArch Androl. (1983)
  314. Nagai M, Hoshide S, Kario K. Sleep duration as a risk factor for cardiovascular disease- a review of the recent literatureCurr Cardiol Rev. (2010)
  315. Rosinger AY, et al. Short sleep duration is associated with inadequate hydration: Cross-cultural evidence from US and Chinese adultsSleep. (2018)
  316. Andrade A, et al. Sleep Quality, Mood and Performance: A Study of Elite Brazilian Volleyball AthletesJ Sports Sci Med. (2016)
  317. Mah CD, et al. The effects of sleep extension on the athletic performance of collegiate basketball playersSleep. (2011)
  318. Andersen ML, et al. The association of testosterone, sleep, and sexual function in men and womenBrain Res. (2011)
  319. Lo JC, et al. Cognitive Performance, Sleepiness, and Mood in Partially Sleep Deprived Adolescents: The Need for Sleep StudySleep. (2016)
  320. Lastella M, Lovell GP, Sargent C. Athletes‘ precompetitive sleep behaviour and its relationship with subsequent precompetitive mood and performanceEur J Sport Sci. (2014)
  321. McClung CA. How might circadian rhythms control mood? Let me count the waysBiol Psychiatry. (2013)
  322. Zohar D, et al. The effects of sleep loss on medical residents‘ emotional reactions to work events: a cognitive-energy modelSleep. (2005)
  323. Tosini G, Ferguson I, Tsubota K. Effects of blue light on the circadian system and eye physiologyMol Vis. (2016)
  324. Bedrosian TA, Nelson RJ. Timing of light exposure affects mood and brain circuitsTransl Psychiatry. (2017)
  325. Heo JY, et al. Effects of smartphone use with and without blue light at night in healthy adults: A randomized, double-blind, cross-over, placebo-controlled comparisonJ Psychiatr Res. (2017)
  326. Esaki Y, et al. Wearing blue light-blocking glasses in the evening advances circadian rhythms in the patients with delayed sleep phase disorder: An open-label trialChronobiol Int. (2016)
  327. Skeldon AC, Phillips AJ, Dijk DJ. The effects of self-selected light-dark cycles and social constraints on human sleep and circadian timing: a modeling approachSci Rep. (2017)
  328. Basner M, et al. ICBEN review of research on the biological effects of noise 2011-2014Noise Health. (2015)
  329. Halperin D. Environmental noise and sleep disturbances: A threat to health?Sleep Sci. (2014)
  330. Hume KI, Brink M, Basner M. Effects of environmental noise on sleepNoise Health. (2012)
  331. Portas CM, et al. Auditory processing across the sleep-wake cycle: simultaneous EEG and fMRI monitoring in humansNeuron. (2000)
  332. Neitzel R, Somers S, Seixas N. Variability of real-world hearing protector attenuation measurementsAnn Occup Hyg. (2006)
  333. Huang CY, Chang ET, Lai HL. Comparing the effects of music and exercise with music for older adults with insomniaAppl Nurs Res. (2016)
  334. Lack LC, et al. The relationship between insomnia and body temperaturesSleep Med Rev. (2008)
  335. Okamoto-Mizuno K, Mizuno K. Effects of thermal environment on sleep and circadian rhythmJ Physiol Anthropol. (2012)
  336. Okamoto-Mizuno K, et al. Effects of humid heat exposure on human sleep stages and body temperatureSleep. (1999)
  337. Murphy PJ, Campbell SS. Nighttime drop in body temperature: a physiological trigger for sleep onset?Sleep. (1997)
  338. Libert JP, et al. Relative and combined effects of heat and noise exposure on sleep in humansSleep. (1991)
  339. Stein MD, Friedmann PD. Disturbed sleep and its relationship to alcohol useSubst Abus. (2005)
  340. Park SY, et al. The Effects of Alcohol on Quality of SleepKorean J Fam Med. (2015)
  341. Stone BM. Sleep and low doses of alcoholElectroencephalogr Clin Neurophysiol. (1980)
  342. Barry RJ, Clarke AR, Johnstone SJ. Caffeine and opening the eyes have additive effects on resting arousal measuresClin Neurophysiol. (2011)
  343. Childs E, de Wit H. Subjective, behavioral, and physiological effects of acute caffeine in light, nondependent caffeine usersPsychopharmacology (Berl). (2006)
  344. Holtzman SG. CGS 15943, a nonxanthine adenosine receptor antagonist: effects on locomotor activity of nontolerant and caffeine-tolerant ratsLife Sci. (1991)
  345. Drake C, et al. Caffeine effects on sleep taken 0, 3, or 6 hours before going to bedJ Clin Sleep Med. (2013)
  346. Baron KG, Reid KJ, Zee PC. Exercise to improve sleep in insomnia: exploration of the bidirectional effectsJ Clin Sleep Med. (2013)
  347. Kline CE. The bidirectional relationship between exercise and sleep: Implications for exercise adherence and sleep improvementAm J Lifestyle Med. (2014)
  348. VanHelder T, Radomski MW. Sleep deprivation and the effect on exercise performanceSports Med. (1989)
  349. Tang NK, Sanborn AN. Better quality sleep promotes daytime physical activity in patients with chronic pain? A multilevel analysis of the within-person relationshipPLoS One. (2014)
  350. Souissi N, et al. Effect of time of day and partial sleep deprivation on short-term, high-power outputChronobiol Int. (2008)
  351. Loprinzi PD, Cardinal BJ. Association between objectively-measured physical activity and sleep, NHANES 2005–2006. Mental Health and Physical ActivityMent Health Phys Act. (2011)
  352. Wunsch K, Kasten N, Fuchs R. The effect of physical activity on sleep quality, well-being, and affect in academic stress periodsNat Sci Sleep. (2017)
  353. Wang F, et al. The effect of meditative movement on sleep quality: A systematic reviewSleep Med Rev. (2016)
  354. Reid KJ, et al. Aerobic exercise improves self-reported sleep and quality of life in older adults with insomniaSleep Med. (2010)
  355. Kovacevic A, et al. The effect of resistance exercise on sleep: A systematic review of randomized controlled trialsSleep Med Rev. (2018)
  356. Hartescu I, Morgan K, Stevinson CD. Increased physical activity improves sleep and mood outcomes in inactive people with insomnia: a randomized controlled trialJ Sleep Res. (2015)
  357. Murray K, et al. The relations between sleep, time of physical activity, and time outdoors among adult womenPLoS One. (2017)
  358. Tahara Y, Aoyama S, Shibata S. The mammalian circadian clock and its entrainment by stress and exerciseJ Physiol Sci. (2017)
  359. 2013 Sleep in America® Poll: Exercise and Sleep (summary of findings), “Exercise is good, regardless of time of day” (pages 46–49).
  360. Swaminathan K, Klerman EB, Phillips AJK. Are Individual Differences in Sleep and Circadian Timing Amplified by Use of Artificial Light Sources?J Biol Rhythms. (2017)
  361. Phillips AJK, et al. Irregular sleep/wake patterns are associated with poorer academic performance and delayed circadian and sleep/wake timingSci Rep. (2017)
  362. Ferracioli-Oda E, Qawasmi A, Bloch MH. Meta-analysis: melatonin for the treatment of primary sleep disordersPLoS One. (2013)
  363. Noyek S, Yaremchuk K, Rotenberg B. Does melatonin have a meaningful role as a sleep aid for jet lag recovery?Laryngoscope. (2016)
  364. Hätönen T, Alila A, Laakso ML. Exogenous melatonin fails to counteract the light-induced phase delay of human melatonin rhythmBrain Res. (1996)
  365. Naylor S, Gleich GJ. Over-the-counter melatonin products and contaminationAm Fam Physician. (1999)
  366. Williamson BL, et al. Structural characterization of contaminants found in commercial preparations of melatonin: similarities to case-related compounds from L-tryptophan associated with eosinophilia-myalgia syndromeChem Res Toxicol. (1998)
  367. Erland LA, Saxena PK. Melatonin Natural Health Products and Supplements: Presence of Serotonin and Significant Variability of Melatonin ContentJ Clin Sleep Med. (2017)
  368. Nielsen FH, Johnson LK, Zeng H. Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleepMagnes Res. (2010)
  369. Held K, et al. Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humansPharmacopsychiatry. (2002)
  370. Costello RB, Moser-Veillon PB. A review of magnesium intake in the elderly. A cause for concern?Magnes Res. (1992)
  371. Nielsen FH, Lukaski HC. Update on the relationship between magnesium and exerciseMagnes Res. (2006)
  372. Tang YM, et al. Relationships between micronutrient losses in sweat and blood pressure among heat-exposed steelworkersInd Health. (2016)
  373. Institute of Medicine (US) Committee on Military Nutrition Research; Marriott BM, editor. Washington (DC). Nutritional Needs in Hot Environments, “Influence of Exercise and Heat on Magnesium Metabolism”National Academies Press (US). (1993)
  374. Consolazio CF, et al. Excretion of sodium, potassium, magnesium and iron in human sweat and the relation of each to balance and requirementsJ Nutr. (1963)
  375. Yoshimura Y, et al. Pharmacokinetic Studies of Orally Administered Magnesium Oxide in RatsYakugaku Zasshi. (2017)
  376. Firoz M, Graber M. Bioavailability of US commercial magnesium preparationsMagnes Res. (2001)
  377. Sayorwan W, et al. The effects of lavender oil inhalation on emotional states, autonomic nervous system, and brain electrical activityJ Med Assoc Thai. (2012)
  378. Field T, et al. Lavender bath oil reduces stress and crying and enhances sleep in very young infantsEarly Hum Dev. (2008)
  379. Lehrner J, et al. Ambient odors of orange and lavender reduce anxiety and improve mood in a dental officePhysiol Behav. (2005)
  380. Lee IS, Lee GJ. Effects of lavender aromatherapy on insomnia and depression in women college studentsTaehan Kanho Hakhoe Chi. (2006)
  381. Lewith GT, Godfrey AD, Prescott P. A single-blinded, randomized pilot study evaluating the aroma of Lavandula augustifolia as a treatment for mild insomniaJ Altern Complement Med. (2005)
  382. Chien LW, Cheng SL, Liu CF. The effect of lavender aromatherapy on autonomic nervous system in midlife women with insomniaEvid Based Complement Alternat Med. (2012)
  383. Goel N, Kim H, Lao RP. An olfactory stimulus modifies nighttime sleep in young men and womenChronobiol Int. (2005)
  384. Kasper S, et al. Silexan in anxiety disorders: Clinical data and pharmacological backgroundWorld J Biol Psychiatry. (2018)
  385. Kasper S, Anghelescu I, Dienel A. Efficacy of orally administered Silexan in patients with anxiety-related restlessness and disturbed sleep–A randomized, placebo-controlled trialEur Neuropsychopharmacol. (2015)
  386. Kasper S, et al. Lavender oil preparation Silexan is effective in generalized anxiety disorder–a randomized, double-blind comparison to placebo and paroxetineInt J Neuropsychopharmacol. (2014)
  387. Kasper S, et al. Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of ‚subsyndromal‘ anxiety disorder: a randomized, double-blind, placebo controlled trialInt Clin Psychopharmacol. (2010)