1. Howes MJ, Perry NS, Houghton PJ. Plants with traditional uses and activities, relevant to the management of Alzheimer’s disease and other cognitive disordersPhytother Res. (2003)
  2. Ha GT, Wong RK, Zhang Y. Huperzine a as potential treatment of Alzheimer’s disease: an assessment on chemistry, pharmacology, and clinical studiesChem Biodivers. (2011)
  3. Ma X, Gang DR. In vitro production of huperzine A, a promising drug candidate for Alzheimer’s diseasePhytochemistry. (2008)
  4. Total Synthesis of (−)-Huperzine A.
  5. Wang XD, et al. Comparison of the effects of cholinesterase inhibitors on {3H}MK-801 binding in rat cerebral cortexNeurosci Lett. (1999)
  6. Rajendran V, et al. Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine BBioorg Med Chem Lett. (2002)
  7. Zhang HY, Tang XC. Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cellsNeurosci Lett. (2000)
  8. Feng S, et al. Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitorsJ Med Chem. (2005)
  9. He XC, et al. Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine BBioorg Med Chem. (2007)
  10. Qian BC, et al. Pharmacokinetics of tablet huperzine A in six volunteersZhongguo Yao Li Xue Bao. (1995)
  11. Li YX, et al. Pharmacokinetics of huperzine A following oral administration to human volunteersEur J Drug Metab Pharmacokinet. (2007)
  12. Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.
  13. Chemistry, Pharmacology, and Clinical Efficacy of the Chinese Nootropic Agent Huperzine A.
  14. Development of huperzine A and B for treatment of Alzheimer’s disease.
  15. Boudinot E, et al. Effects of acetylcholinesterase and butyrylcholinesterase inhibition on breathing in mice adapted or not to reduced acetylcholinesterasePharmacol Biochem Behav. (2005)
  16. Lane RM, Potkin SG, Enz A. Targeting acetylcholinesterase and butyrylcholinesterase in dementiaInt J Neuropsychopharmacol. (2006)
  17. Ved HS, et al. Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamateNeuroreport. (1997)
  18. Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695.
  19. Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine.
  20. The NMDA receptor ion channel: a site for binding of Huperzine A.
  21. Ma T, et al. Huperzine A promotes hippocampal neurogenesis in vitro and in vivoBrain Res. (2013)