Berberín

Literatúra

  1. Effects of a nutraceutical combination on left ventricular remodeling and vasoreactivity in subjects with the metabolic syndrome.
  2. Cicero AF, Rovati LC, Setnikar I. Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents. A single-blind clinical investigationArzneimittelforschung. (2007)
  3. Marazzi G, et al. Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patientsAdv Ther. (2011)
  4. Vuddanda PR, Chakraborty S, Singh S. Berberine: a potential phytochemical with multispectrum therapeutic activitiesExpert Opin Investig Drugs. (2010)
  5. Cernáková M, Kostálová D. Antimicrobial activity of berberine–a constituent of Mahonia aquifoliumFolia Microbiol (Praha). (2002)
  6. Sheng WD, et al. Treatment of chloroquine-resistant malaria using pyrimethamine in combination with berberine, tetracycline or cotrimoxazoleEast Afr Med J. (1997)
  7. Kaneda Y, et al. In vitro effects of berberine sulphate on the growth and structure of Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalisAnn Trop Med Parasitol. (1991)
  8. Ghosh AK, Bhattacharyya FK, Ghosh DK. Leishmania donovani: amastigote inhibition and mode of action of berberineExp Parasitol. (1985)
  9. Kaneda Y, Tanaka T, Saw T. Effects of berberine, a plant alkaloid, on the growth of anaerobic protozoa in axenic cultureTokai J Exp Clin Med. (1990)
  10. Grycová L, Dostál J, Marek R. Quaternary protoberberine alkaloidsPhytochemistry. (2007)
  11. Singh IP, Mahajan S. Berberine and its derivatives: a patent review (2009 – 2012)Expert Opin Ther Pat. (2012)
  12. Krivogorsky B, et al. Structure-activity studies of some berberine analogs as inhibitors of Toxoplasma gondiiBioorg Med Chem Lett. (2012)
  13. Avula B, Wang YH, Khan IA. Quantitative determination of alkaloids from roots of Hydrastis canadensis L. and dietary supplements using ultra-performance liquid chromatography with UV detectionJ AOAC Int. (2012)
  14. Chen J, et al. Analysis of major alkaloids in Rhizoma coptidis by capillary electrophoresis-electrospray-time of flight mass spectrometry with different background electrolytesElectrophoresis. (2008)
  15. Tillhon M, et al. Berberine: new perspectives for old remediesBiochem Pharmacol. (2012)
  16. Wang JR, et al. Formation and conformation of baicalin-berberine and wogonoside-berberine complexesChem Pharm Bull (Tokyo). (2012)
  17. Turner N, et al. Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin actionDiabetes. (2008)
  18. Cheng Z, et al. 8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse modelsBioorg Med Chem. (2010)
  19. Subeki, et al. Antibabesial activity of protoberberine alkaloids and 20-hydroxyecdysone from Arcangelisia flava against Babesia gibsoni in cultureJ Vet Med Sci. (2005)
  20. Schramm A, et al. HERG channel inhibitors in extracts of Coptidis rhizomaPlanta Med. (2011)
  21. Zhang TT, et al. CPU 86017, p-chlorobenzyltetrahydroberberine chloride, attenuates monocrotaline-induced pulmonary hypertension by suppressing endothelin pathwayActa Pharmacol Sin. (2005)
  22. Gao J, et al. Raisanberine protected pulmonary arterial rings and cardiac myocytes of rats against hypoxia injury by suppressing NADPH oxidase and calcium influxActa Pharmacol Sin. (2012)
  23. Pan GY, et al. Inhibitory action of berberine on glucose absorptionYao Xue Xue Bao. (2003)
  24. Maeng HJ, et al. P-glycoprotein-mediated transport of berberine across Caco-2 cell monolayersJ Pharm Sci. (2002)
  25. Chen W, et al. Bioavailability study of berberine and the enhancing effects of TPGS on intestinal absorption in ratsAAPS PharmSciTech. (2011)
  26. Pan GY, et al. The involvement of P-glycoprotein in berberine absorptionPharmacol Toxicol. (2002)
  27. Chae HW, et al. Effect of ion-pair formation with bile salts on the in vitro cellular transport of berberineArch Pharm Res. (2008)
  28. Tsai P, Tsai TH. Simultaneous determination of berberine in rat blood, liver and bile using microdialysis coupled to high-performance liquid chromatographyJ Chromatogr A. (2002)
  29. Qiu W, et al. Effect of berberine on the pharmacokinetics of substrates of CYP3A and P-gpPhytother Res. (2009)
  30. Zhang X, et al. Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoproteinXenobiotica. (2011)
  31. Hwang YH, et al. Effects of berberine and hwangryunhaedok-tang on oral bioavailability and pharmacokinetics of ciprofloxacin in ratsEvid Based Complement Alternat Med. (2012)
  32. Shan YQ, et al. Berberine analogue IMB-Y53 improves glucose-lowering efficacy by averting cellular efflux especially P-glycoprotein effluxMetabolism. (2012)
  33. Di Pierro F, et al. Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic controlDiabetes Metab Syndr Obes. (2012)
  34. Zhou Y, et al. Drug-drug interactions between ketoconazole and berberine in rats: pharmacokinetic effects benefit pharmacodynamic synergismPhytother Res. (2012)
  35. Reversible Increase in Tight Junction Permeability to Macromolecules in Rat Ileal Mucosa In Vitro by Sodium Caprate, a Constituent of Milk Fat.
  36. Zhang M, et al. Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesisMol Cell Endocrinol. (2012)
  37. Enhancement of Sodium Caprate on Intestine Absorption and Antidiabetic Action of Berberine.
  38. Fan D, et al. Enhancement by sodium caprate and sodium deoxycholate of the gastrointestinal absorption of berberine chloride in ratsDrug Dev Ind Pharm. (2012)
  39. Zhang Y, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberineJ Clin Endocrinol Metab. (2008)
  40. Khin-Maung-U, et al. Clinical trial of berberine in acute watery diarrhoeaBr Med J (Clin Res Ed). (1985)
  41. Khan AY, Hossain M, Kumar GS. Binding of plant alkaloids berberine and palmatine to serum albumins: a thermodynamic investigationMol Biol Rep. (2013)
  42. Hazra S, Hossain M, Suresh Kumar G. Binding of isoquinoline alkaloids berberine, palmatine and coralyne to hemoglobin: structural and thermodynamic characterization studiesMol Biosyst. (2013)
  43. Wang YX, et al. Synthesis and structure-activity relationship of berberine analogues in LDLR up-regulation and AMPK activationBioorg Med Chem. (2012)
  44. Li Y, et al. Bioactivities of berberine metabolites after transformation through CYP450 isoenzymesJ Transl Med. (2011)
  45. Zuo F, et al. Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometryDrug Metab Dispos. (2006)
  46. Qiu F, et al. Isolation and identification of urinary metabolites of berberine in rats and humansDrug Metab Dispos. (2008)
  47. Pan JF, et al. Identification of three sulfate-conjugated metabolites of berberine chloride in healthy volunteers‘ urine after oral administrationActa Pharmacol Sin. (2002)
  48. Virtanen P, et al. Natural protoberberine alkaloids from Enantia chlorantha, palmatine, columbamine and jatrorrhizine for thioacetamide-traumatized rat liverActa Anat (Basel). (1988)
  49. Zhao Y, et al. The in vitro inhibition of human CYP1A2, CYP2D6 and CYP3A4 by tetrahydropalmatine, neferine and berberinePhytother Res. (2012)
  50. Guo Y, et al. Repeated administration of berberine inhibits cytochromes P450 in humansEur J Clin Pharmacol. (2012)
  51. Xin HW, et al. The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteersMethods Find Exp Clin Pharmacol. (2006)
  52. Wu X, et al. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic studyEur J Clin Pharmacol. (2005)
  53. Budzinski JW, et al. Modulation of human cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) in Caco-2 cell monolayers by selected commercial-source milk thistle and goldenseal productsCan J Physiol Pharmacol. (2007)
  54. Hermann R, von Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactionsPlanta Med. (2012)
  55. Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine.
  56. Chatuphonprasert W, et al. Modulations of cytochrome P450 expression in diabetic mice by berberineChem Biol Interact. (2012)
  57. Cheng Q, et al. Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesityMol Pharm. (2008)
  58. Viollet B, et al. Cellular and molecular mechanisms of metformin: an overviewClin Sci (Lond). (2012)
  59. Han Y, et al. Redox regulation of the AMP-activated protein kinasePLoS One. (2010)
  60. Cheng Z, et al. Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPKBiochim Biophys Acta. (2006)
  61. Wang H, et al. Atrogin-1 affects muscle protein synthesis and degradation when energy metabolism is impaired by the antidiabetes drug berberineDiabetes. (2010)
  62. Liu LZ, et al. The pivotal role of protein kinase C zeta (PKCzeta) in insulin- and AMP-activated protein kinase (AMPK)-mediated glucose uptake in muscle cellsCell Signal. (2010)
  63. Kim WS, et al. Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activityAm J Physiol Endocrinol Metab. (2009)
  64. Brusq JM, et al. Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberineJ Lipid Res. (2006)
  65. Kong W, et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statinsNat Med. (2004)
  66. Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1α.
  67. Turnley AM, et al. Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous systemJ Neurochem. (1999)
  68. Neidle S. Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancerFEBS J. (2010)
  69. Ou TM, et al. G-quadruplexes: targets in anticancer drug designChemMedChem. (2008)
  70. Monchaud D, Teulade-Fichou MP. A hitchhiker’s guide to G-quadruplex ligandsOrg Biomol Chem. (2008)
  71. Arora A, et al. Binding of berberine to human telomeric quadruplex – spectroscopic, calorimetric and molecular modeling studiesFEBS J. (2008)
  72. Zhang WJ, et al. 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNABioorg Med Chem. (2007)
  73. Ma Y, et al. Synthesis and evaluation of 9-O-substituted berberine derivatives containing aza-aromatic terminal group as highly selective telomeric G-quadruplex stabilizing ligandsBioorg Med Chem Lett. (2009)
  74. Bazzicalupi C, et al. The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1Nucleic Acids Res. (2012)
  75. Naasani I, et al. FJ5002: a potent telomerase inhibitor identified by exploiting the disease-oriented screening program with COMPARE analysisCancer Res. (1999)
  76. Mahata S, et al. Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cellsMol Cancer. (2011)
  77. Wang X, et al. The uptake and transport behavior of berberine in Coptidis Rhizoma extract through rat primary cultured cortical neuronsNeurosci Lett. (2005)
  78. Olmez E, Ilhan M. Evaluation of the alpha-adrenoceptor antagonistic action of berberine in isolated organsArzneimittelforschung. (1992)
  79. Hui KK, et al. Interaction of berberine with human platelet alpha 2 adrenoceptorsLife Sci. (1991)
  80. Vizi ES, et al. Berbanes: a new class of selective alpha 2-adrenoceptor antagonistsJ Med Chem. (1987)
  81. Zhao X, et al. Screening the bioactive compounds in aqueous extract of Coptidis rhizoma which specifically bind to rabbit lung tissues beta2-adrenoceptor using an affinity chromatographic selection methodJ Chromatogr B Analyt Technol Biomed Life Sci. (2010)
  82. Kulkarni SK, Dhir A. On the mechanism of antidepressant-like action of berberine chlorideEur J Pharmacol. (2008)
  83. Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice.
  84. Kong LD, Cheng CH, Tan RX. Monoamine oxidase inhibitors from rhizoma of Coptis chinensisPlanta Med. (2001)
  85. Castillo J, et al. LED fluorescence spectroscopy for direct determination of monoamine oxidase B inactivationAnal Biochem. (2005)
  86. Inhibition of Dopamine Biosynthesis by Protoberberine Alkaloids in PC12 Cells.
  87. Kalalian-Moghaddam H, et al. Hippocampal synaptic plasticity restoration and anti-apoptotic effect underlie berberine improvement of learning and memory in streptozotocin-diabetic ratsEur J Pharmacol. (2013)
  88. Reisi P, et al. Treadmill running improves long-term potentiation (LTP) defects in streptozotocin-induced diabetes at dentate gyrus in ratsPathophysiology. (2010)
  89. Artola A. Diabetes-, stress- and ageing-related changes in synaptic plasticity in hippocampus and neocortex–the same metaplastic processEur J Pharmacol. (2008)
  90. Ye L, Wang F, Yang RH. Diabetes impairs learning performance and affects the mitochondrial function of hippocampal pyramidal neuronsBrain Res. (2011)
  91. Bhutada P, et al. Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetesBehav Brain Res. (2011)
  92. Kulkarni SK, Dhir A. Possible involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant activity of berberine chlorideEur J Pharmacol. (2007)
  93. Kulkarni SK, Dhir A. sigma-1 receptors in major depression and anxietyExpert Rev Neurother. (2009)
  94. Understanding the Molecular Mechanism of Sigma-1 Receptors: Towards A Hypothesis that Sigma-1 Receptors are Intracellular Amplifiers for Signal Transduction.
  95. Current hypotheses on sigma receptors and their physiological role: possible implications in psychiatry.
  96. Monnet FP. Sigma-1 receptor as regulator of neuronal intracellular Ca2+: clinical and therapeutic relevanceBiol Cell. (2005)
  97. Fontanilla D, et al. The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulatorScience. (2009)
  98. Huang L, et al. Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesteraseBioorg Med Chem Lett. (2010)
  99. Jung HA, et al. Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloidsBiol Pharm Bull. (2009)
  100. Ingkaninan K, et al. Acetylcholinesterase inhibitors from Stephania venosa tuberJ Pharm Pharmacol. (2006)
  101. Chen XW, et al. Interaction of herbal compounds with biological targets: a case study with berberineScientificWorldJournal. (2012)
  102. Asai M, et al. Berberine alters the processing of Alzheimer’s amyloid precursor protein to decrease Abeta secretionBiochem Biophys Res Commun. (2007)
  103. Zhu F, et al. Decrease in the production of β-amyloid by berberine inhibition of the expression of β-secretase in HEK293 cellsBMC Neurosci. (2011)
  104. Lee B, et al. Phellodendron amurense and Its Major Alkaloid Compound, Berberine Ameliorates Scopolamine-Induced Neuronal Impairment and Memory Dysfunction in RatsKorean J Physiol Pharmacol. (2012)
  105. Zhang Q, et al. Hypoxia-inducible factor 1 mediates the anti-apoptosis of berberine in neurons during hypoxia/ischemiaActa Physiol Hung. (2012)
  106. Hu J, et al. PI3K p55γ promoter activity enhancement is involved in the anti-apoptotic effect of berberine against cerebral ischemia-reperfusionEur J Pharmacol. (2012)
  107. Kwon IH, et al. Effects of berberine on 6-hydroxydopamine-induced neurotoxicity in PC12 cells and a rat model of Parkinson’s diseaseNeurosci Lett. (2010)
  108. Segura Aguilar J, Kostrzewa RM. Neurotoxins and neurotoxic species implicated in neurodegenerationNeurotox Res. (2004)
  109. Nagatsu T. Isoquinoline neurotoxins in the brain and Parkinson’s diseaseNeurosci Res. (1997)
  110. Lee B, et al. Effect of berberine on depression- and anxiety-like behaviors and activation of the noradrenergic system induced by development of morphine dependence in ratsKorean J Physiol Pharmacol. (2012)
  111. Chang W, et al. Berberine Attenuates Ischemia-Reperfusion Injury Via Regulation of Adenosine-5′-monophosphate Kinase Activity in Both Non-ischemic and Ischemic Areas of the Rat HeartCardiovasc Drugs Ther. (2012)
  112. Wang LH, et al. Berberine alleviates ischemic arrhythmias via recovering depressed I(to) and I(Ca) currents in diabetic ratsPhytomedicine. (2012)
  113. Gong LL, et al. Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in ratsAtherosclerosis. (2012)
  114. Kim YM, et al. Palmatine from Coptidis rhizoma reduces ischemia-reperfusion-mediated acute myocardial injury in the ratFood Chem Toxicol. (2009)
  115. Soloff MS, et al. Cloning, characterization, and expression of the rat relaxin geneGene. (2003)
  116. Gu HP, et al. Up-regulating relaxin expression by G-quadruplex interactive ligand to achieve antifibrotic actionEndocrinology. (2012)
  117. Du XJ, et al. Cardiovascular effects of relaxin: from basic science to clinical therapyNat Rev Cardiol. (2010)
  118. Salehi S, Filtz TM. Berberine possesses muscarinic agonist-like properties in cultured rodent cardiomyocytesPharmacol Res. (2011)
  119. Effect of berberine on Cdk9 and cyclin T1 expressions in myocardium of diabetic rats.
  120. Zeng XH, Zeng XJ, Li YY. Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathyAm J Cardiol. (2003)
  121. Zheng L, et al. Protective effect of berberine on cardiac myocyte injured by ischemia-reperfusionSichuan Da Xue Xue Bao Yi Xue Ban. (2003)
  122. Xiao HB, et al. Berberine inhibits dyslipidemia in C57BL/6 mice with lipopolysaccharide induced inflammationPharmacol Rep. (2012)
  123. Lee S, et al. Berberine-induced LDLR up-regulation involves JNK pathwayBiochem Biophys Res Commun. (2007)
  124. Extracellular Signal-Regulated Kinase–Dependent Stabilization of Hepatic Low-Density Lipoprotein Receptor mRNA by Herbal Medicine Berberine.
  125. Duff CJ, Hooper NM. PCSK9: an emerging target for treatment of hypercholesterolemiaExpert Opin Ther Targets. (2011)
  126. Feingold KR, et al. Inflammation stimulates the expression of PCSK9Biochem Biophys Res Commun. (2008)
  127. Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine.
  128. Hu Y, et al. Lipid-lowering effect of berberine in human subjects and ratsPhytomedicine. (2012)
  129. Derosa G, et al. Effects of berberine on lipid profile in subjects with low cardiovascular riskExpert Opin Biol Ther. (2013)
  130. Dong H, et al. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysisEvid Based Complement Alternat Med. (2012)
  131. Fatehi-Hassanabad Z, et al. The antihypertensive and vasodilator effects of aqueous extract from Berberis vulgaris fruit on hypertensive ratsPhytother Res. (2005)
  132. Chun YT, et al. A biochemical study on the hypotensive effect of berberine in ratsGen Pharmacol. (1979)
  133. Lau CW, et al. Cardiovascular actions of berberineCardiovasc Drug Rev. (2001)
  134. Wong KK. Mechanism of the aortic relaxation induced by low concentrations of berberinePlanta Med. (1998)
  135. Effects of berberine on angiotensin-converting enzyme and NO/cGMP system in vessels.
  136. Cheng B, et al. Cardiovascular aspects of pharmacology of berberine: I. Alpha-adrenoceptor blocking action of berberine in isolated rat anococcygeus muscle and rabbit aortic stripJ Tongji Med Univ. (1987)
  137. Bova S, et al. On the mechanism of vasodilating action of berberine: possible role of inositol lipid signaling systemJ Pharmacol Exp Ther. (1992)
  138. Huang CG, et al. Effect of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cellsThromb Res. (2002)
  139. Imanshahidi M, Hosseinzadeh H. Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberinePhytother Res. (2008)
  140. Cao JW, et al. Effects of berberine on intracellular free calcium in smooth muscle cells of Guinea pig colonDigestion. (2001)
  141. Huang Z, et al. Berberine-induced inhibition of adipocyte enhancer-binding protein 1 attenuates oxidized low-density lipoprotein accumulation and foam cell formation in phorbol 12-myristate 13-acetate-induced macrophagesEur J Pharmacol. (2012)
  142. Huang Z, et al. Berberine‑attenuated monocyte adhesion to endothelial cells induced by oxidized low‑density lipoprotein via inhibition of adhesion molecule expressionMol Med Report. (2013)
  143. Wang Q, et al. Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2PLoS One. (2011)
  144. Effect of berberine on glucose transport in adipocyte and its mechanism.
  145. Huang C, et al. Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathwayBiochem Biophys Res Commun. (2006)
  146. Yang J, et al. Berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokines profile in human preadipocytes and metabolic syndrome patientsEvid Based Complement Alternat Med. (2012)
  147. Adipocyte stress: The endoplasmic reticulum and metabolic disease.
  148. Pham TP, Kwon J, Shin J. Berberine exerts anti-adipogenic activity through up-regulation of C/EBP inhibitors, CHOP and DEC2Biochem Biophys Res Commun. (2011)
  149. Bae S, Yoon Y. Anti-Adipogenic Activity of Berberine is Not Mediated by the WNT/β-Catenin PathwayPhytother Res. (2012)
  150. Zhou J, Zhou S. Berberine regulates peroxisome proliferator-activated receptors and positive transcription elongation factor b expression in diabetic adipocytesEur J Pharmacol. (2010)
  151. Zhou L, et al. Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytesBiochim Biophys Acta. (2011)
  152. Zhou L, et al. Berberine acutely inhibits insulin secretion from beta-cells through 3′,5′-cyclic adenosine 5′-monophosphate signaling pathwayEndocrinology. (2008)
  153. Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptorsEndocr Rev. (2005)
  154. Basu R, et al. Selective downregulation of the high molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: differential regulation from nondiabetic subjectsDiabetes. (2007)
  155. Wang Y, et al. Post-translational modifications of adiponectin: mechanisms and functional implicationsBiochem J. (2008)
  156. Li Y, et al. Activation of AMPK by berberine promotes adiponectin multimerization in 3T3-L1 adipocytesFEBS Lett. (2011)
  157. Lin H, Li Z. Adiponectin self-regulates its expression and multimerization in adipose tissue: an autocrine/paracrine mechanismMed Hypotheses. (2012)
  158. Prabhakar PK, Doble M. Effect of Natural Products on Commercial Oral Antidiabetic Drugs in Enhancing 2-Deoxyglucose Uptake by 3T3-L1 AdipocytesTher Adv Endocrinol Metab. (2011)
  159. Wang SH, et al. Effect of Astragalus polysaccharides and berberine on carbohydrate metabolism and cell differentiation in 3T3-L1 adipocytesZhongguo Zhong Xi Yi Jie He Za Zhi. (2004)
  160. Chen C, Zhang Y, Huang C. Berberine inhibits PTP1B activity and mimics insulin actionBiochem Biophys Res Commun. (2010)
  161. Cok A, et al. Berberine acutely activates the glucose transport activity of GLUT1Biochimie. (2011)
  162. Kim SH, et al. Berberine activates GLUT1-mediated glucose uptake in 3T3-L1 adipocytesBiol Pharm Bull. (2007)
  163. Bustanji Y, et al. Berberine potently inhibits protein tyrosine phosphatase 1B: investigation by docking simulation and experimental validationJ Enzyme Inhib Med Chem. (2006)
  164. Yi P, et al. Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbetaWorld J Gastroenterol. (2008)
  165. Choi BH, et al. Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyteExp Mol Med. (2006)
  166. Yi P, Lu FE, Chen G. Molecular mechanism of berberine in improving insulin resistance induced by free fatty acid through inhibiting nuclear trascription factor-kappaB p65 in 3T3-L1 adipocytesZhongguo Zhong Xi Yi Jie He Za Zhi. (2007)
  167. Yan HM, et al. Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver DiseasePLoS One. (2015)
  168. Pan GY, et al. The antihyperglycaemic activity of berberine arises from a decrease of glucose absorptionPlanta Med. (2003)
  169. Liu SZ, et al. Antihyperglycemic effect of the traditional Chinese scutellaria-coptis herb couple and its main components in streptozotocin-induced diabetic ratsJ Ethnopharmacol. (2012)
  170. Liu L, et al. Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro studyNaunyn Schmiedebergs Arch Pharmacol. (2010)
  171. Liu L, et al. Berberine attenuates intestinal disaccharidases in streptozotocin-induced diabetic ratsPharmazie. (2008)
  172. Tintu I, et al. An isoquinoline alkaloid, berberine, can inhibit fungal alpha amylase: enzyme kinetic and molecular modeling studiesChem Biol Drug Des. (2012)
  173. Ni YX. Therapeutic effect of berberine on 60 patients with type II diabetes mellitus and experimental researchZhong Xi Yi Jie He Za Zhi. (1988)
  174. Sterne JA, Gavaghan D, Egger M. Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literatureJ Clin Epidemiol. (2000)
  175. Zhang H, et al. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expressionMetabolism. (2010)
  176. Pérez-Rubio KG, et al. Effect of berberine administration on metabolic syndrome, insulin sensitivity, and insulin secretionMetab Syndr Relat Disord. (2013)
  177. Efficacy of Berberine in Patients with Type 2 Diabetes.
  178. Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK.
  179. Ma X, et al. Berberine-induced activation of 5′-adenosine monophosphate-activated protein kinase and glucose transport in rat skeletal musclesMetabolism. (2010)
  180. Gomes AP, et al. Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesisBiochim Biophys Acta. (2012)
  181. Liu LZ, et al. Berberine modulates insulin signaling transduction in insulin-resistant cellsMol Cell Endocrinol. (2010)
  182. Kong WJ, et al. Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expressionMetabolism. (2009)
  183. Krawiec BJ, et al. AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cellsAm J Physiol Endocrinol Metab. (2007)
  184. Wang XH, Jiang SM, Sun QW. Effects of berberine on human rheumatoid arthritis fibroblast-like synoviocytesExp Biol Med (Maywood). (2011)
  185. Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage.
  186. Hu PF, et al. Protective effects of berberine in an experimental rat osteoarthritis modelPhytother Res. (2011)
  187. Ivanovska N, Philipov S, Hristova M. Influence of berberine on T-cell mediated immunityImmunopharmacol Immunotoxicol. (1999)
  188. Yan F, et al. Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated miceAm J Physiol Gastrointest Liver Physiol. (2012)
  189. Lee IA, Hyun YJ, Kim DH. Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and NF-κB activationEur J Pharmacol. (2010)
  190. Kuo CL, Chi CW, Liu TY. The anti-inflammatory potential of berberine in vitro and in vivoCancer Lett. (2004)
  191. Park JE, et al. Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264.7 cellsBioorg Med Chem Lett. (2011)
  192. Huang Z, et al. Suppression of oxLDL-induced MMP-9 and EMMPRIN expression by berberine via inhibition of NF-κB activation in human THP-1 macrophagesAnat Rec (Hoboken). (2012)
  193. Guan S, et al. Effects of berberine on expression of LOX-1 and SR-BI in human macrophage-derived foam cells induced by ox-LDLAm J Chin Med. (2010)
  194. Kim BH, et al. Inhibition of the signalling kinase JAK3 alleviates inflammation in monoarthritic ratsBr J Pharmacol. (2011)
  195. Papageorgiou AC, Wikman LE. Is JAK3 a new drug target for immunomodulation-based therapiesTrends Pharmacol Sci. (2004)
  196. Malaviya R, et al. Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxisJ Biol Chem. (1999)
  197. Cecil CE, et al. Inhibition of H1N1 influenza A virus growth and induction of inflammatory mediators by the isoquinoline alkaloid berberine and extracts of goldenseal (Hydrastis canadensis)Int Immunopharmacol. (2011)
  198. Schröder M, Kaufman RJ. The mammalian unfolded protein responseAnnu Rev Biochem. (2005)
  199. Chen TC, et al. Involvement of reactive oxygen species and caspase-dependent pathway in berberine-induced cell cycle arrest and apoptosis in C6 rat glioma cellsInt J Oncol. (2009)
  200. Eom KS, et al. Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunctionBiol Pharm Bull. (2010)
  201. Lin JP, et al. GADD153 mediates berberine-induced apoptosis in human cervical cancer Ca ski cellsAnticancer Res. (2007)
  202. Lin CC, et al. Berberine induces apoptosis in human HSC-3 oral cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathwayAnticancer Res. (2007)
  203. Sun Y, et al. A systematic review of the anticancer properties of berberine, a natural product from Chinese herbsAnticancer Drugs. (2009)
  204. Hao X, et al. Berberine ameliorates pro-inflammatory cytokine-induced endoplasmic reticulum stress in human intestinal epithelial cells in vitroInflammation. (2012)
  205. Wang ZS, et al. Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cellsActa Pharmacol Sin. (2010)
  206. Zha W, et al. Berberine inhibits HIV protease inhibitor-induced inflammatory response by modulating ER stress signaling pathways in murine macrophagesPLoS One. (2010)
  207. Zhou J, et al. Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic ratsEur J Pharmacol. (2009)
  208. Liu J, et al. Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cellsBiochem Biophys Res Commun. (2009)
  209. Doyle ME, Egan JM. Mechanisms of action of glucagon-like peptide 1 in the pancreasPharmacol Ther. (2007)
  210. Meier JJ, Nauck MA. Glucagon-like peptide 1(GLP-1) in biology and pathologyDiabetes Metab Res Rev. (2005)
  211. Holst JJ, Gromada J. Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humansAm J Physiol Endocrinol Metab. (2004)
  212. Li J1, et al. Berberine represses DAXX gene transcription and induces cancer cell apoptosisLab Invest. (2013)
  213. Marverti G1, et al. Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cellsInt J Oncol. (2013)
  214. Tsang CM, et al. Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblastsBMC Cancer. (2013)
  215. Wu HL1, et al. Berberine-induced apoptosis of human leukemia HL-60 cells is associated with down-regulation of nucleophosmin/B23 and telomerase activityInt J Cancer. (1999)
  216. Fu L1, et al. Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell GrowthPLoS One. (2013)
  217. Ho YT1, et al. Berberine induced apoptosis via promoting the expression of caspase-8, -9 and -3, apoptosis-inducing factor and endonuclease G in SCC-4 human tongue squamous carcinoma cancer cellsAnticancer Res. (2009)
  218. Peng PL1, et al. Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2Toxicol Appl Pharmacol. (2006)
  219. Hamsa TP1, Kuttan G. Berberine inhibits pulmonary metastasis through down-regulation of MMP in metastatic B16F-10 melanoma cellsPhytother Res. (2012)
  220. Eisenberg-Lerner A1, Kimchi A. The paradox of autophagy and its implication in cancer etiology and therapyApoptosis. (2009)
  221. Wang N1, et al. Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanismJ Cell Biochem. (2010)
  222. Peng PL1, et al. Synergistic tumor-killing effect of radiation and berberine combined treatment in lung cancer: the contribution of autophagic cell deathInt J Radiat Oncol Biol Phys. (2008)
  223. Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitorsAdv Enzyme Regul. (1984)
  224. Tong N, et al. Berberine sensitizes mutliple human cancer cells to the anticancer effects of doxorubicin in vitroOncol Lett. (2012)
  225. Zhao X, et al. Protective effects of berberine on doxorubicin-induced hepatotoxicity in miceBiol Pharm Bull. (2012)
  226. Choi MS1, et al. Berberine inhibits human neuroblastoma cell growth through induction of p53-dependent apoptosisAnticancer Res. (2008)
  227. Eom KS1, et al. Berberine induces G1 arrest and apoptosis in human glioblastoma T98G cells through mitochondrial/caspases pathwayBiol Pharm Bull. (2008)
  228. Patil JB1, Kim J, Jayaprakasha GK. Berberine induces apoptosis in breast cancer cells (MCF-7) through mitochondrial-dependent pathwayEur J Pharmacol. (2010)
  229. Marquez RT, Xu L. Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switchAm J Cancer Res. (2012)
  230. Bcl-2 Inhibition of Autophagy: A New Route to Cancer?.
  231. Park KS, et al. Berberine inhibited the growth of thyroid cancer cell lines 8505C and TPC1Yonsei Med J. (2012)
  232. Wang L, et al. Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factorPLoS One. (2012)
  233. Choi MS1, et al. Berberine inhibits p53-dependent cell growth through induction of apoptosis of prostate cancer cellsInt J Oncol. (2009)
  234. Meeran SM1, Katiyar S, Katiyar SK. Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generationToxicol Appl Pharmacol. (2008)
  235. Letasiová S1, et al. Berberine-antiproliferative activity in vitro and induction of apoptosis/necrosis of the U937 and B16 cellsCancer Lett. (2006)
  236. Lin CC1, et al. Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3Anticancer Res. (2006)
  237. Xia X, et al. Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesisPLoS One. (2011)
  238. Li H, et al. Hepatocyte nuclear factor 1alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberineJ Biol Chem. (2009)
  239. Cameron J, et al. Berberine decreases PCSK9 expression in HepG2 cellsAtherosclerosis. (2008)
  240. Zhang BJ, et al. Protection by and anti-oxidant mechanism of berberine against rat liver fibrosis induced by multiple hepatotoxic factorsClin Exp Pharmacol Physiol. (2008)
  241. Sun X, et al. Berberine inhibits hepatic stellate cell proliferation and prevents experimental liver fibrosisBiol Pharm Bull. (2009)
  242. Wang N, et al. A comparative study on the hepatoprotective action of bear bile and coptidis rhizoma aqueous extract on experimental liver fibrosis in ratsBMC Complement Altern Med. (2012)
  243. Chang X, et al. Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in ratsJ Lipid Res. (2010)
  244. Wetterau JR, Lin MC, Jamil H. Microsomal triglyceride transfer proteinBiochim Biophys Acta. (1997)
  245. Lu SS, et al. Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic ratsJ Endocrinol. (2009)
  246. Sack RB, Froehlich JL. Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxinsInfect Immun. (1982)
  247. Yuan J, Shen XZ, Zhu XS. Effect of berberine on transit time of human small intestineZhongguo Zhong Xi Yi Jie He Za Zhi. (1994)
  248. Strober W, Fuss I, Mannon P. The fundamental basis of inflammatory bowel diseaseJ Clin Invest. (2007)
  249. Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel diseaseNature. (2007)
  250. Zhang M, et al. Evidence for the complementary and synergistic effects of the three-alkaloid combination regimen containing berberine, hypaconitine and skimmianine on the ulcerative colitis rats induced by trinitrobenzene-sulfonic acidEur J Pharmacol. (2011)
  251. Zhou H, Mineshita S. The effect of berberine chloride on experimental colitis in rats in vivo and in vitroJ Pharmacol Exp Ther. (2000)
  252. Kawashima K, et al. Pharmacological properties of traditional medicine (XXIX): effect of Hange-shashin-to and the combinations of its herbal constituents on rat experimental colitisBiol Pharm Bull. (2004)
  253. Hong T, et al. Suppressive effect of berberine on experimental dextran sulfate sodium-induced colitisImmunopharmacol Immunotoxicol. (2012)
  254. Zhang X, et al. Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed ratsPLoS One. (2012)
  255. Jiang XW, et al. Effects of berberine gelatin on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial in a Chinese cohortOral Surg Oral Med Oral Pathol Oral Radiol. (2012)
  256. Gao N, Zhao TY, Li XJ. The protective effect of berberine on β-cell lipoapoptosisJ Endocrinol Invest. (2011)
  257. Gu JJ, Gao FY, Zhao TY. A preliminary investigation of the mechanisms underlying the effect of berberine in preventing high-fat diet-induced insulin resistance in ratsJ Physiol Pharmacol. (2012)
  258. Leng SH, Lu FE, Xu LJ. Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretionActa Pharmacol Sin. (2004)
  259. Ko BS, et al. Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizomaBiol Pharm Bull. (2005)
  260. Yin J, et al. Effects of berberine on glucose metabolism in vitroMetabolism. (2002)
  261. Leclerc I, Rutter GA. AMP-activated protein kinase: a new beta-cell glucose sensor?: Regulation by amino acids and calcium ionsDiabetes. (2004)
  262. Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic beta cells.
  263. Tsuboi T, et al. Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cellsBiochem J. (2003)
  264. Rayasam GV, et al. Identification of berberine as a novel agonist of fatty acid receptor GPR40Phytother Res. (2010)
  265. Abdel-Haq H, et al. Relaxant effects of Hydrastis canadensis L. and its major alkaloids on guinea pig isolated tracheaPharmacol Toxicol. (2000)
  266. Wang FL, et al. Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic ratsMol Biol Rep. (2012)
  267. Tang LQ, et al. Berberine ameliorates renal injury by regulating G proteins-AC- cAMP signaling in diabetic rats with nephropathyMol Biol Rep. (2012)
  268. Wu D, et al. Ameliorative effect of berberine on renal damage in rats with diabetes induced by high-fat diet and streptozotocinPhytomedicine. (2012)
  269. Liu W, et al. Berberine reduces fibronectin and collagen accumulation in rat glomerular mesangial cells cultured under high glucose conditionMol Cell Biochem. (2009)
  270. Jiang Q, et al. Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: involvement of NF-κB signaling pathwayMol Cell Endocrinol. (2011)
  271. Liu W, et al. Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injuryEur J Pharmacol. (2010)
  272. Oh JH, et al. Sequential effects of high glucose on mesangial cell transforming growth factor-beta 1 and fibronectin synthesisKidney Int. (1998)
  273. Mogyorósi A, et al. Utility of serum and urinary transforming growth factor-beta levels as markers of diabetic nephropathyNephron. (2000)
  274. Lan T, et al. Berberine suppresses high glucose-induced TGF-β1 and fibronectin synthesis in mesangial cells through inhibition of sphingosine kinase 1/AP-1 pathwayEur J Pharmacol. (2012)
  275. Taha TA, Hannun YA, Obeid LM. Sphingosine kinase: biochemical and cellular regulation and role in diseaseJ Biochem Mol Biol. (2006)
  276. Lan T, et al. Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cellsMol Endocrinol. (2011)
  277. Lan T, et al. Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathwayArch Biochem Biophys. (2010)
  278. Liu W, et al. Berberine inhibits aldose reductase and oxidative stress in rat mesangial cells cultured under high glucoseArch Biochem Biophys. (2008)
  279. Liu WH, et al. Berberine ameliorates renal injury in streptozotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductaseChin Med J (Engl). (2008)
  280. Bashir S, Gilani AH. Antiurolithic effect of berberine is mediated through multiple pathwaysEur J Pharmacol. (2011)
  281. Li HB, et al. Effects and mechanism of berberine on the hypertensive renal injury rats induced by enriched high fat-salt-fructose dietZhong Yao Cai. (2011)
  282. Bashir S, et al. Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in ratsPhytother Res. (2010)
  283. Seki T, Morohashi M. Effect of some alkaloids, flavonoids and triterpenoids, contents of Japanese-Chinese traditional herbal medicines, on the lipogenesis of sebaceous glandsSkin Pharmacol. (1993)
  284. Namba T, et al. Study on baths with crude drug. II.: the effects of coptidis rhizoma extracts as skin permeation enhancerYakugaku Zasshi. (1995)
  285. Inbaraj JJ, et al. Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 1. BerberineChem Res Toxicol. (2001)
  286. Tan Y, et al. Antioxidant properties of berberine on cultured rabbit corpus cavernosum smooth muscle cells injured by hydrogen peroxideActa Pharmacol Sin. (2007)
  287. Tan Y, et al. Effect of berberine on the mRNA expression of nitric oxide synthase (NOS) in rat corpus cavernosumJ Huazhong Univ Sci Technolog Med Sci. (2005)
  288. Chiou WF, Chen J, Chen CF. Relaxation of corpus cavernosum and raised intracavernous pressure by berberine in rabbitBr J Pharmacol. (1998)
  289. Tan Y, et al. Effect of berberine on the mRNA expression of phosphodiesterase type 5 (PDE5) in rat corpus cavernosumZhonghua Nan Ke Xue. (2004)
  290. Tan Y, et al. Effects of berberine on cyclic GMP and cyclic AMP levels in rabbit corpus cavernosum in vitroZhonghua Nan Ke Xue. (2005)
  291. Drewes SE, George J, Khan F. Recent findings on natural products with erectile-dysfunction activityPhytochemistry. (2003)
  292. Liu GL, et al. Endoplasmic reticulum stress mediating downregulated StAR and 3-beta-HSD and low plasma testosterone caused by hypoxia is attenuated by CPU86017-RS and nifedipineJ Biomed Sci. (2012)
  293. Zhang GL, et al. CPU86017-RS attenuate hypoxia-induced testicular dysfunction in mice by normalizing androgen biosynthesis genes and pro-inflammatory cytokinesActa Pharmacol Sin. (2012)
  294. Wei W, et al. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndromeEur J Endocrinol. (2012)
  295. Zhao W, et al. Reduction of blood lipid by berberine in hyperlipidemic patients with chronic hepatitis or liver cirrhosisBiomed Pharmacother. (2008)
  296. Prabhakar PK, Doble M. Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubesPhytomedicine. (2009)
  297. Kwon M, et al. Organic cation transporter-mediated drug-drug interaction potential between berberine and metforminArch Pharm Res. (2015)
  298. Vogel RA. PCSK9 inhibition: the next statinJ Am Coll Cardiol. (2012)
  299. Rashid S, et al. Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9Proc Natl Acad Sci U S A. (2005)
  300. Welder G, et al. High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterolJ Lipid Res. (2010)
  301. Dubuc G, et al. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemiaArterioscler Thromb Vasc Biol. (2004)
  302. Kong WJ, et al. Combination of simvastatin with berberine improves the lipid-lowering efficacyMetabolism. (2008)
  303. Affuso F, et al. Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled studyNutr Metab Cardiovasc Dis. (2010)
  304. Pisciotta L, Bellocchio A, Bertolini S. Nutraceutical pill containing berberine versus ezetimibe on plasma lipid pattern in hypercholesterolemic subjects and its additive effect in patients with familial hypercholesterolemia on stable cholesterol-lowering treatmentLipids Health Dis. (2012)
  305. Liu J, et al. Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: a meta-analysis of randomized controlled trialsChin Med. (2006)
  306. Zhou S, Lim LY, Chowbay B. Herbal modulation of P-glycoproteinDrug Metab Rev. (2004)
  307. Xue L, et al. Effects and interaction of icariin, curculigoside, and berberine in er-xian decoction, a traditional chinese medicinal formula, on osteoclastic bone resorptionEvid Based Complement Alternat Med. (2012)
  308. Vrzal R, et al. Activation of the aryl hydrocarbon receptor by berberine in HepG2 and H4IIE cells: Biphasic effect on CYP1A1Biochem Pharmacol. (2005)
  309. Zhi D, et al. The enhancement of cardiac toxicity by concomitant administration of Berberine and macrolidesEur J Pharm Sci. (2015)
  310. Chan E. Displacement of bilirubin from albumin by berberineBiol Neonate. (1993)
  311. Affuso F, et al. A nutraceutical combination improves insulin sensitivity in patients with metabolic syndromeWorld J Cardiol. (2012)
  312. Bahadoran Z, et al. The Nitrate-Independent Blood Pressure-Lowering Effect of Beetroot Juice: A Systematic Review and Meta-AnalysisAdv Nutr. (2017)
  313. Lara J, et al. Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysisEur J Nutr. (2016)
  314. Aune D, et al. Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality-a systematic review and dose-response meta-analysis of prospective studiesInt J Epidemiol. (2017)
  315. Ried K. Garlic Lowers Blood Pressure in Hypertensive Individuals, Regulates Serum Cholesterol, and Stimulates Immunity: An Updated Meta-analysis and ReviewJ Nutr. (2016)
  316. Ried K, Toben C, Fakler P. Effect of garlic on serum lipids: an updated meta-analysisNutr Rev. (2013)
  317. El Asmar MS, Naoum JJ, Arbid EJ. Vitamin k dependent proteins and the role of vitamin k2 in the modulation of vascular calcification: a reviewOman Med J. (2014)
  318. Knapen MH, et al. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trialThromb Haemost. (2015)
  319. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc.
  320. Cockayne S, et al. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trialsArch Intern Med. (2006)
  321. Kodama S, et al. Fasting and post-challenge glucose as quantitative cardiovascular risk factors: a meta-analysisJ Atheroscler Thromb. (2012)
  322. Mannucci E, et al. Is glucose control important for prevention of cardiovascular disease in diabetes?Diabetes Care. (2013)
  323. Lan J, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertensionJ Ethnopharmacol. (2015)
  324. Schaffer SW, et al. Physiological roles of taurine in heart and muscleJ Biomed Sci. (2010)
  325. Ahmadian M, Dabidi Roshan V, Ashourpore E. Taurine Supplementation Improves Functional Capacity, Myocardial Oxygen Consumption, and Electrical Activity in Heart FailureJ Diet Suppl. (2017)
  326. Ahmadian M, et al. Taurine supplementation has anti-atherogenic and anti-inflammatory effects before and after incremental exercise in heart failureTher Adv Cardiovasc Dis. (2017)
  327. Beyranvand MR, et al. Effect of taurine supplementation on exercise capacity of patients with heart failureJ Cardiol. (2011)
  328. Sun Q, et al. Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled StudyHypertension. (2016)
  329. Militante JD, Lombardini JB. Treatment of hypertension with oral taurine: experimental and clinical studiesAmino Acids. (2002)