Kazeínová bielkovina

Pôsobí na: rast svalov a cvičenie, úbytok tuku, zachovanie celkového zdravia

Kazeín je mliečna bielkovina, ktorá je základom pri výrobe syrov a tvarohu. Má schopnosť vytvárať gél. Spomaľuje črevnú motilitu a pomaly sa vstrebáva. Po pridaní vody vytvára pudingovú hmotu.

Užívanie

Podobne ak ou iných bielkovinových doplnkov aj pri kazeíne závisí dávkovanie od individuálnych denných bielkovinových cieľov. Napr. atlét, alebo veľmi aktívny človek pokúšajúci sa odbúrať telesný tuk ale zachovať svalovú hmotu potrebuje denne prijať 1,5-2,2 g/kg telesnej hmotnosti. Pre prevažne sediaceho, človeka, ktorý sa nepokúša zmeniť zloženie tela postačuje dávka 0,8 g/kg telesnej hmotnosti. Ak sa denná dávka dosiahne prostredníctvom stravy, nie je potrebné užívanie doplnkov. Obézny ľudia by sa nemali držať týchto odporúčaných dávok, pretože prepočet na telesnú hmotnosť by vyústil do veľmi vysokých dávok. V akom prípade sa denná dávka počíta podľa hmotnosti, ktorú chce daná osoba dosiahnuť.

Medicínske upozornenie!

Literatúra

  1. Kinsella JE. Milk proteins: physicochemical and functional propertiesCrit Rev Food Sci Nutr. (1984)
  2. Lönnerdal B, Forsum E. Casein content of human milkAm J Clin Nutr. (1985)
  3. Kunz C, Lönnerdal B. Re-evaluation of the whey protein/casein ratio of human milkActa Paediatr. (1992)
  4. Belloque J, Ramos M. Determination of the casein content in bovine milk by 31P-NMRJ Dairy Res. (2002)
  5. Kumar A, et al. Chymosin and other milk coagulants: sources and biotechnological interventionsCrit Rev Biotechnol. (2010)
  6. Johnson ME, Lucey JA. Major technological advances and trends in cheeseJ Dairy Sci. (2006)
  7. Huffman LM, Harper WJ. Maximizing the value of milk through separation technologiesJ Dairy Sci. (1999)
  8. Pastorino AJ, Hansen CL, McMahon DJ. Effect of salt on structure-function relationships of cheeseJ Dairy Sci. (2003)
  9. Pastorino AJ, Hansen CL, McMahon DJ. Effect of pH on the chemical composition and structure-function relationships of cheddar cheeseJ Dairy Sci. (2003)
  10. Lilbaek HM, et al. Improving the yield of Mozzarella cheese by phospholipase treatment of milkJ Dairy Sci. (2006)
  11. Everard CD, et al. Effects of cutting intensity and stirring speed on syneresis and curd losses during cheese manufactureJ Dairy Sci. (2008)
  12. Microfiltration in Cheese and Whey Processing.
  13. Solanki G, Rizvi SS. Physico-chemical properties of skim milk retentates from microfiltrationJ Dairy Sci. (2001)
  14. Muro Urista C, et al. Review: Production and functionality of active peptides from milkFood Sci Technol Int. (2011)
  15. Kim JH, et al. Efficacy of alphas1-casein hydrolysate on stress-related symptoms in womenEur J Clin Nutr. (2007)
  16. Messaoudi M, et al. Effects of a tryptic hydrolysate from bovine milk alphaS1-casein on hemodynamic responses in healthy human volunteers facing successive mental and physical stress situationsEur J Nutr. (2005)
  17. Guesdon B, et al. A tryptic hydrolysate from bovine milk alphaS1-casein improves sleep in rats subjected to chronic mild stressPeptides. (2006)
  18. Rousseau-Ralliard D, et al. Inhibitory effect of αS1- and αS2-casein hydrolysates on angiotensin I-converting enzyme in human endothelial cells in vitro, rat aortic tissue ex vivo, and renovascular hypertensive rats in vivoJ Dairy Sci. (2010)
  19. Schulmeister U, et al. Cloning, expression, and mapping of allergenic determinants of alphaS1-casein, a major cow’s milk allergenJ Immunol. (2009)
  20. Cadée JA, et al. Bovine casein hydrolysate (c12 Peptide) reduces blood pressure in prehypertensive subjectsAm J Hypertens. (2007)
  21. Townsend RR, et al. A randomized, double-blind, placebo-controlled trial of casein protein hydrolysate (C12 peptide) in human essential hypertensionAm J Hypertens. (2004)
  22. Keogh JB, et al. Effect of glycomacropeptide fractions on cholecystokinin and food intakeBr J Nutr. (2010)
  23. Teschemacher H, Koch G, Brantl V. Milk protein-derived opioid receptor ligandsBiopolymers. (1997)
  24. Taché Y, Garrick T, Raybould H. Central nervous system action of peptides to influence gastrointestinal motor functionGastroenterology. (1990)
  25. Nakamura H, et al. Influences of casein hydrolysate ingestion on cerebral activity, autonomic nerve activity, and anxietyJ Physiol Anthropol. (2010)
  26. Messaoudi M, et al. Anxiolytic-like effects and safety profile of a tryptic hydrolysate from bovine alpha s1-casein in ratsFundam Clin Pharmacol. (2009)
  27. James S, Montgomery P, Williams K. Omega-3 fatty acids supplementation for autism spectrum disorders (ASD)Cochrane Database Syst Rev. (2011)
  28. Rossignol DA, Frye RE. Melatonin in autism spectrum disorders: a systematic review and meta-analysisDev Med Child Neurol. (2011)
  29. Mazahery H, et al. Vitamin D and Autism Spectrum Disorder: A Literature ReviewNutrients. (2016)
  30. Nye C, Brice A. Combined vitamin B6-magnesium treatment in autism spectrum disorderCochrane Database Syst Rev. (2005)
  31. Marí-Bauset S, et al. Evidence of the gluten-free and casein-free diet in autism spectrum disorders: a systematic reviewJ Child Neurol. (2014)
  32. Winburn E, et al. Parents‘ and child health professionals‘ attitudes towards dietary interventions for children with autism spectrum disordersJ Autism Dev Disord. (2014)
  33. Panksepp J. A neurochemical theory of autismTrends in Neurosciences. (1979)
  34. Shattock P, Whiteley P. Biochemical aspects in autism spectrum disorders: updating the opioid-excess theory and presenting new opportunities for biomedical interventionExpert Opin Ther Targets. (2002)
  35. van De Sande MM, van Buul VJ, Brouns FJ. Autism and nutrition: the role of the gut-brain axisNutr Res Rev. (2014)
  36. de Magistris L, et al. Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relativesJ Pediatr Gastroenterol Nutr. (2010)
  37. Dalton N, et al. Gut permeability in autism spectrum disordersAutism Res. (2014)
  38. Dettmer K, et al. Autism and urinary exogenous neuropeptides: development of an on-line SPE-HPLC-tandem mass spectrometry method to test the opioid excess theoryAnal Bioanal Chem. (2007)
  39. Cass H, et al. Absence of urinary opioid peptides in children with autismArch Dis Child. (2008)
  40. Millward C, et al. Gluten- and casein-free diets for autistic spectrum disorderCochrane Database Syst Rev. (2008)
  41. Elder JH, et al. The gluten-free, casein-free diet in autism: results of a preliminary double blind clinical trialJ Autism Dev Disord. (2006)
  42. Seung, et al. The gluten- and casein-free diet and autism: Communication outcomes from a preliminary double-blind clinical trial.Journal of Medical Speech-Language Pathology. (2007)
  43. Navarro F, et al. Are ‚leaky gut‘ and behavior associated with gluten and dairy containing diet in children with autism spectrum disorders?Nutr Neurosci. (2015)
  44. Pusponegoro HD, et al. Gluten and casein supplementation does not increase symptoms in children with autism spectrum disorderActa Paediatr. (2015)
  45. Hyman SL, et al. The Gluten-Free/Casein-Free Diet: A Double-Blind Challenge Trial in Children with AutismJ Autism Dev Disord. (2016)
  46. Piwowarczyk A, et al. Gluten- and casein-free diet and autism spectrum disorders in children: a systematic reviewEur J Nutr. (2018)
  47. Sathe N, et al. Nutritional and Dietary Interventions for Autism Spectrum Disorder: A Systematic ReviewPediatrics. (2017)
  48. Buie T, et al. Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus reportPediatrics. (2010)
  49. Vasa RA, et al. Assessment and Treatment of Anxiety in Youth With Autism Spectrum DisordersPediatrics. (2016)
  50. Zwaigenbaum L, et al. Early Intervention for Children With Autism Spectrum Disorder Under 3 Years of Age: Recommendations for Practice and ResearchPediatrics. (2015)
  51. Macfarlane GT, Macfarlane S. Bacteria, colonic fermentation, and gastrointestinal healthJ AOAC Int. (2012)
  52. MacLean DA, Graham TE, Saltin B. Branched-chain amino acids augment ammonia metabolism while attenuating protein breakdown during exerciseAm J Physiol. (1994)
  53. EASTOE JE. The amino acid composition of mammalian collagen and gelatinBiochem J. (1955)
  54. Hays NP, et al. Effects of whey and fortified collagen hydrolysate protein supplements on nitrogen balance and body composition in older womenJ Am Diet Assoc. (2009)
  55. Zdzieblik D, et al. Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trialBr J Nutr. (2015)
  56. Rutherfurd SM, et al. Protein digestibility-corrected amino acid scores and digestible indispensable amino acid scores differentially describe protein quality in growing male ratsJ Nutr. (2015)
  57. Mathai JK, Liu Y, Stein HH. Values for digestible indispensable amino acid scores (DIAAS) for some dairy and plant proteins may better describe protein quality than values calculated using the concept for protein digestibility-corrected amino acid scores (PDCAAS)Br J Nutr. (2017)