Glutén (lepok)

Glutén (lepok) je bielkovina, ktorá sa nachádza v pšenici a príbuzných obilninách. Nemali by ho konzumovať ľudia s celiakiou. Niekedy môže spôsobovať problémy aj ľuďom s inými črevnými poruchami. Neexistuje veľa dôkazov, že by lepok poškodzoval zdravý zažívací trakt.

Užívanie

Glutén nie je výživovým doplnkom a pri doplnkovom užívaní neposkytuje telu žiadne zdravotné výhody. Jeho doplnkové užívanie sa neodporúča.

Medicínske upozornenie!

Literatúra

  1. Shwry PR, et al. Biotechnology of breadmaking: unraveling and manipulating the multi-protein gluten complexBiotechnology (N Y). (1995)
  2. Anjum FM, et al. Wheat gluten: high molecular weight glutenin subunits–structure, genetics, and relation to dough elasticityJ Food Sci. (2007)
  3. Shewry PR, et al. The structure and properties of gluten: an elastic protein from wheat grainPhilos Trans R Soc Lond B Biol Sci. (2002)
  4. Arentz-Hansen H, et al. The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminaseJ Exp Med. (2000)
  5. Gujral N, Freeman HJ, Thomson AB. Celiac disease: prevalence, diagnosis, pathogenesis and treatmentWorld J Gastroenterol. (2012)
  6. Hardy MY, et al. Ingestion of oats and barley in patients with celiac disease mobilizes cross-reactive T cells activated by avenin peptides and immuno-dominant hordein peptidesJ Autoimmun. (2015)
  7. Arentz-Hansen H, et al. The molecular basis for oat intolerance in patients with celiac diseasePLoS Med. (2004)
  8. Carroccio A, et al. Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entityAm J Gastroenterol. (2012)
  9. Biesiekierski JR, et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trialAm J Gastroenterol. (2011)
  10. Capannolo A, et al. Non-Celiac Gluten Sensitivity among Patients Perceiving Gluten-Related SymptomsDigestion. (2015)
  11. Shahbazkhani B, et al. Non-Celiac Gluten Sensitivity Has Narrowed the Spectrum of Irritable Bowel Syndrome: A Double-Blind Randomized Placebo-Controlled TrialNutrients. (2015)
  12. Elli L, et al. Evidence for the Presence of Non-Celiac Gluten Sensitivity in Patients with Functional Gastrointestinal Symptoms: Results from a Multicenter Randomized Double-Blind Placebo-Controlled Gluten ChallengeNutrients. (2016)
  13. Gibson PR, Shepherd SJ. Food choice as a key management strategy for functional gastrointestinal symptomsAm J Gastroenterol. (2012)
  14. Biesiekierski JR, et al. No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydratesGastroenterology. (2013)
  15. Van Belzen MJ, et al. A major non-HLA locus in celiac disease maps to chromosome 19Gastroenterology. (2003)
  16. Rampertab SD, et al. Trends in the presentation of celiac diseaseAm J Med. (2006)
  17. Fasano A, Catassi C. Current approaches to diagnosis and treatment of celiac disease: an evolving spectrumGastroenterology. (2001)
  18. Freeman HJ. Risk factors in familial forms of celiac diseaseWorld J Gastroenterol. (2010)
  19. Samasca G, et al. Challenges in the celiac disease diagnosis; Prague consensusGastroenterol Hepatol Bed Bench. (2017)
  20. Bardella MT, et al. Serological markers for coeliac disease: is it time to change?Dig Liver Dis. (2001)
  21. Taavela J, et al. A Prospective Study on the Usefulness of Duodenal Bulb Biopsies in Celiac Disease Diagnosis in Children: Urging CautionAm J Gastroenterol. (2016)
  22. Volta U, et al. Seronegative celiac disease: Shedding light on an obscure clinical entityDig Liver Dis. (2016)
  23. Corrao G, et al. Mortality in patients with coeliac disease and their relatives: a cohort studyLancet. (2001)
  24. Sollid LM. Molecular basis of celiac diseaseAnnu Rev Immunol. (2000)
  25. James S, Montgomery P, Williams K. Omega-3 fatty acids supplementation for autism spectrum disorders (ASD)Cochrane Database Syst Rev. (2011)
  26. Rossignol DA, Frye RE. Melatonin in autism spectrum disorders: a systematic review and meta-analysisDev Med Child Neurol. (2011)
  27. Mazahery H, et al. Vitamin D and Autism Spectrum Disorder: A Literature ReviewNutrients. (2016)
  28. Nye C, Brice A. Combined vitamin B6-magnesium treatment in autism spectrum disorderCochrane Database Syst Rev. (2005)
  29. Marí-Bauset S, et al. Evidence of the gluten-free and casein-free diet in autism spectrum disorders: a systematic reviewJ Child Neurol. (2014)
  30. Winburn E, et al. Parents‘ and child health professionals‘ attitudes towards dietary interventions for children with autism spectrum disordersJ Autism Dev Disord. (2014)
  31. Panksepp J. A neurochemical theory of autismTrends in Neurosciences. (1979)
  32. Shattock P, Whiteley P. Biochemical aspects in autism spectrum disorders: updating the opioid-excess theory and presenting new opportunities for biomedical interventionExpert Opin Ther Targets. (2002)
  33. van De Sande MM, van Buul VJ, Brouns FJ. Autism and nutrition: the role of the gut-brain axisNutr Res Rev. (2014)
  34. de Magistris L, et al. Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relativesJ Pediatr Gastroenterol Nutr. (2010)
  35. Dalton N, et al. Gut permeability in autism spectrum disordersAutism Res. (2014)
  36. Dettmer K, et al. Autism and urinary exogenous neuropeptides: development of an on-line SPE-HPLC-tandem mass spectrometry method to test the opioid excess theoryAnal Bioanal Chem. (2007)
  37. Cass H, et al. Absence of urinary opioid peptides in children with autismArch Dis Child. (2008)
  38. Millward C, et al. Gluten- and casein-free diets for autistic spectrum disorderCochrane Database Syst Rev. (2008)
  39. Elder JH, et al. The gluten-free, casein-free diet in autism: results of a preliminary double blind clinical trialJ Autism Dev Disord. (2006)
  40. Seung, et al. The gluten- and casein-free diet and autism: Communication outcomes from a preliminary double-blind clinical trial.Journal of Medical Speech-Language Pathology. (2007)
  41. Navarro F, et al. Are ‚leaky gut‘ and behavior associated with gluten and dairy containing diet in children with autism spectrum disorders?Nutr Neurosci. (2015)
  42. Pusponegoro HD, et al. Gluten and casein supplementation does not increase symptoms in children with autism spectrum disorderActa Paediatr. (2015)
  43. Hyman SL, et al. The Gluten-Free/Casein-Free Diet: A Double-Blind Challenge Trial in Children with AutismJ Autism Dev Disord. (2016)
  44. Piwowarczyk A, et al. Gluten- and casein-free diet and autism spectrum disorders in children: a systematic reviewEur J Nutr. (2018)
  45. Sathe N, et al. Nutritional and Dietary Interventions for Autism Spectrum Disorder: A Systematic ReviewPediatrics. (2017)
  46. Buie T, et al. Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus reportPediatrics. (2010)
  47. Vasa RA, et al. Assessment and Treatment of Anxiety in Youth With Autism Spectrum DisordersPediatrics. (2016)
  48. Zwaigenbaum L, et al. Early Intervention for Children With Autism Spectrum Disorder Under 3 Years of Age: Recommendations for Practice and ResearchPediatrics. (2015)