Pôsobí na: zachovanie celkového zdravia
Valín je jednou z trojvetvových aminokyselín. Iba zriedkavo sa testuje izolovane. Pravdepodobne je pre telo najmenej dôležitou aminokyselinou s rozvetveným reťazcom (BCAA) a nezdá sa, že by s ním bol spojený nejaký jedinečný benefit.
Užívanie
V súčasnosti nemáme dosť údajov na odporučenie nejakej optimálnej dávky. Nemáme ani informácie o tom, na aký účel by sa mal valín užívať.
Literatúra
- Nutraceutical Effects of Branched-Chain Amino Acids on Skeletal Muscle.
- FONES WS, SOBER HA, WHITE J. The conversion of D-valine to glycogen in the rat. Arch Biochem Biophys. (1951)
- FONES WS, WAALKES TP, WHITE J. The conversion of L-valine to glucose and glycogen in the rat. Arch Biochem Biophys. (1951)
- FONES WS, WHITE J. The conversion of L-valine to glycogen and carbon dioxide in rats receiving p-dimethylaminoazobenzene. J Natl Cancer Inst. (1951)
- Birkhahn RH, Robertson LA, Okuno M. Isoleucine and valine oxidation following skeletal trauma in rats. J Trauma. (1986)
- Komatsu H, et al. Effect of valine-depleted total parenteral nutrition on fatty liver development in tumor-bearing rats. Nutrition. (1998)
- Nishihira T, et al. Anti-cancer therapy with valine-depleted amino acid imbalance solution. Tohoku J Exp Med. (1988)
- Gloaguen M, et al. Providing a diet deficient in valine but with excess leucine results in a rapid decrease in feed intake and modifies the postprandial plasma amino acid and α-keto acid concentrations in pigs. J Anim Sci. (2012)
- Nishihira T, et al. Prevention of fatty liver and maintenance of systemic valine depletion using a newly developed dual infusion system. JPEN J Parenter Enteral Nutr. (1995)
- Armon C. Sports and trauma in amyotrophic lateral sclerosis revisited. J Neurol Sci. (2007)
- Chiò A, et al. Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players. Brain. (2005)
- Belli S, Vanacore N. Proportionate mortality of Italian soccer players: is amyotrophic lateral sclerosis an occupational disease. Eur J Epidemiol. (2005)
- Valenti M, et al. Amyotrophic lateral sclerosis and sports: a case-control study. Eur J Neurol. (2005)
- Carunchio I, et al. Increased levels of p70S6 phosphorylation in the G93A mouse model of Amyotrophic Lateral Sclerosis and in valine-exposed cortical neurons in culture. Exp Neurol. (2010)
- Vucic S, Kiernan MC. Cortical excitability testing distinguishes Kennedy’s disease from amyotrophic lateral sclerosis. Clin Neurophysiol. (2008)
- Zanette G, et al. Changes in motor cortex inhibition over time in patients with amyotrophic lateral sclerosis. J Neurol. (2002)
- Pieri M, et al. Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosis. Exp Neurol. (2009)
- van Zundert B, et al. Neonatal neuronal circuitry shows hyperexcitable disturbance in a mouse model of the adult-onset neurodegenerative disease amyotrophic lateral sclerosis. J Neurosci. (2008)
- Doi M, et al. Isoleucine, a potent plasma glucose-lowering amino acid, stimulates glucose uptake in C2C12 myotubes. Biochem Biophys Res Commun. (2003)
- Fasching P, et al. Insulin production following intravenous glucose, arginine, and valine: different pattern in patients with impaired glucose tolerance and non-insulin-dependent diabetes mellitus. Metabolism. (1994)
- Tokunaga C, Yoshino K, Yonezawa K. mTOR integrates amino acid- and energy-sensing pathways. Biochem Biophys Res Commun. (2004)
- Fox HL, et al. Amino acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytes. Am J Physiol. (1998)
- Lynch CJ, et al. Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes. J Cell Biochem. (2000)
- Kakazu E, et al. Extracellular branched-chain amino acids, especially valine, regulate maturation and function of monocyte-derived dendritic cells. J Immunol. (2007)
- Kakazu E, et al. Branched chain amino acids enhance the maturation and function of myeloid dendritic cells ex vivo in patients with advanced cirrhosis. Hepatology. (2009)
- MacDonald AJ, et al. Monocyte-derived dendritic cell function in chronic hepatitis C is impaired at physiological numbers of dendritic cells. Clin Exp Immunol. (2007)
- Kawaguchi T, et al. Valine, a branched-chain amino Acid, reduced HCV viral load and led to eradication of HCV by interferon therapy in a decompensated cirrhotic patient. Case Rep Gastroenterol. (2012)